Rchr
J-GLOBAL ID:200901038774653983   Update date: Feb. 01, 2024

Fujimoto Takahiro

フジモト タカヒロ | Fujimoto Takahiro
Research field  (6): Neuroscience - general ,  Pathobiochemistry ,  Cell biology ,  Medical biochemistry ,  Pathobiochemistry ,  Molecular biology
Research keywords  (12): 脳形成異常 ,  神経幹細胞 ,  精神遅滞 ,  ジストロフィン ,  病態医科学 ,  分子病態学 ,  細胞生物学 ,  分子生物学 ,  Pathological medical chemistry ,  Molecular pathology ,  Cell biology ,  Molecular biology
Research theme for competitive and other funds  (12):
  • 2023 - 2026 疾患モデルを駆使した筋ジストロフィーの治療法開発
  • 2021 - 2024 Molecular pathogenesis of brain malformations in de novo postzygotic mutations in the brain
  • 2021 - 2024 Functional analysis of dystrophin in blood-brain barrier and its relevance to epilepsy
  • 2018 - 2021 Elucidation of molecular pathomechanisms and the search for therapeutic targets of brain malformations, by employing cerebral organoids generated from patients-derived neural stem/progenitor cells
  • 2018 - 2021 脳型ジストロフィン分子ネットワーク解析を基盤としたてんかん標的分子の同定
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Papers (14):
  • Hisashi Takahashi, Takahiro Fujimoto, Takeshi Yaoi, Shinji Fushiki, Kyoko Itoh. Leukemia inhibitory factor shortens primary cilia by upregulating C-C motif chemokine 2 in human neural stem/progenitor cells. Genes to cells : devoted to molecular & cellular mechanisms. 2023
  • Yoshihiro Taura, Takenori Tozawa, Takahiro Fujimoto, Eisuke Ichise, Tomohiro Chiyonobu, Kyoko Itoh, Tomoko Iehara. Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to Transport Syntaxin1A to the Plasma Membrane. Neuroscience. 2023. 524. 256-268
  • Takahiro Fujimoto, Kirsten Stam, Takeshi Yaoi, Kenta Nakano, Tetsuya Arai, Tadashi Okamura, Kyoko Itoh. Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons. Molecular neurobiology. 2023. 60. 7. 3664-3677
  • Kaori Kiso-Farnè, Takeshi Yaoi, Takahiro Fujimoto, Kyoko Itoh. Low Doses of Bisphenol A Disrupt Neuronal Differentiation of Human Neuronal Stem/Progenitor Cells. Acta histochemica et cytochemica. 2022. 55. 6. 193-202
  • Takahiro Fujimoto, Takeshi Yaoi, Kenta Nakano, Tetsuya Arai, Tadashi Okamura, Kyoko Itoh. Generation of dystrophin short product-specific tag-insertion mouse: distinct Dp71 glycoprotein complexes at inhibitory postsynapse and glia limitans. Cellular and molecular life sciences : CMLS. 2022. 79. 2. 109-109
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MISC (40):
Patents (5):
Books (1):
  • 薬物依存と遺伝子発現調節(cAMP, MAPKを中心に)
    Clinical Neuroscience, 中外医学社 2004
Lectures and oral presentations  (18):
  • ジストロフィン遺伝子産物Dp71の脳における役割
    (2022)
  • ジストロフィン分子機能の理解に立脚したデュシェンヌ型筋ジストロフィー機序解明を目指して
    (第63回日本神経病理学会総会学術研究会 2022)
  • Molecular analysis of a dystrophin gene product, Dp71, in the developing and adult mouse brains
    (SCIENTIFIC SYMPOSIUM DOUBLE DEGREE MASTER PROGRAMME KYOTO PREFECTURAL UNIVERSITY OF MEDICINE AND MAASTRICHT UNIVERSITY 2021)
  • Dystrophin short isoform, Dp71, is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells
    (11th FENS Forum of Neuroscience 2018)
  • Dystrophin short isoform, Dp71, is regulated by phosphorylation and ubiquitin-proteasome system in neuronal cells
    (22nd Biennial Meeting of the International Society of Developmental Neuroscience 2018)
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Awards (1):
  • 2010 - 第12回福岡大学医学会賞金賞 Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice
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