Rchr
J-GLOBAL ID：200901039835910492
Update date: Jan. 30, 2024
Kawahara Hiroharu
カワハラ ヒロハル | Kawahara Hiroharu
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
http://www.kct.ac.jp
,
http://www.kct.ac.jp/facility/cec/index.html
Research field (3)：
Immunology
, Applied molecular and cellular biology
, Functional biochemistry
Research keywords (5)：
抗体
, 細胞培養
, 食品機能
, 細胞工学
, Cell technology
Research theme for competitive and other funds (19)：
- 2019 - 2022 Next generation smart handling innovations to be explicit knowledge through integration with Cyber-Physical Systems
- 2015 - 2018 Creation of a smart handling system using the non-contact motion control and the functional analysis technology
- 2014 - 2017 Establishment of high expression system for therapeutic protein production using human cells
- 2016 - 2017 アレルギー緩和効果を有したイチゴの機能性評価と周年利用技術の開発
- 2011 - 2013 Development of techniques for establishing the fully human antibody high producing human cell lines
- 2011 - 2013 Research of the non-contact functional analysis system for the next-generation bio support instrumentation development by the robot control technology
- 2008 - 2010 Development of the specific antibody therapy targeting cancer antigen recognized by tumor infiltrating B lymphocytes.
- 2007 - 2009 医薬生産用GMP対応ヒト細胞株の育種
- 2006 - 2009 ヒト細胞を用いたイチゴの免疫機能性因子探索技術の開発
- 2005 - 2007 細胞内タンパク質高速定量解析顕微鏡の開発
- 2005 - 2007 ヒト細胞を用いたタンパク質受託生産の事業化
- 2002 - 2004 ヒト細胞を用いた次世代型高機能タンパク質生産システムの開発
- 2001 - 2002 Development and application of the control methods against alveolar bone resorption using human monoclonal antibody
- 1999 - 2000 ヒト型モノクローナル抗体の研究用試薬としての製品化
- Production of proteins with human cell lines
- Quntification of cell function with fluorescence conjugated antibodies
- Development of human tissue reconstruction culture
- Effects of various food stuff on immune system by using human cells.
- Production of various human cell lines
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Papers (29)：
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Katsuhiko Kida, Daisuke Hatanaka, Masataka Minami, Taiyo Suzuki, Masashi Iwakami, Masaki Kobayashi, Hisato Hayashi, Hiroharu Kawahara, Masato Horikawa, Tatsuro Kanaki. Simple chitin-based cell culture platform for production of biopharmaceuticals. Biotechnology Letters. 2023. 45. 10. 1265-1277
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Akira Iwamoto, Yuichi Inoue, Hirofumi Tachibana, Hiroharu Kawahara. Immunomodulatory effect of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in allergic conditions in vitro and in vivo. Cytotechnology. 2021. 73. 3. 333-342
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Akira Iwamoto, Yuichi Inoue, Hirofumi Tachibana, Hiroharu Kawahara. Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro. Cytotechnology. 2019. 71. 2. 573-581
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Akinobu Tanaka, Qinchang Zhu, Hui Tan, Hiroki Horiba, Koichiro Ohnuki, Yasuhiro Mori, Ryoko Yamauchi, Hiroya Ishikawa, Akira Iwamoto, Hiroharu Kawahara, et al. Biological Activities and Phytochemical Profiles of Extracts from Different Parts of Bamboo (Phyllostachys pubescens). MOLECULES. 2014. 19. 6. 8238-8260
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Akira Iwamoto, Aiko Inoue, Yuichi Inoue, Koji Yamada, Hirofumi Tachibana, Hiroharu Kawahara. Anti-allergic effect of strawberry extract. JOURNAL OF FUNCTIONAL FOODS. 2013. 5. 4. 1947-1955
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MISC (27)：
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Yuichi Inoue, Akira Iwamoto, Aiko Inoue, Hiroharu Kawahara. Establishment and characterization of new human cell lines for recombinant therapeutic protein production. BMC Proceedings 9(Suppl9) P3. 2015
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Kanaki Tatsuro, Hayashi Hisato, Saruhashi Koichiro, Kawahara Hiroharu, Nishino Taito. 2P-218 New 3D culture system of MDCK cells using Polymer2. 2015. 67. 229-229
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Kanaki Tatsuro, Otani Ayako, Kawahara Hiroharu, Nishino Taito. 3P-031 A 3D culture system of CHO-K1 cells using FP001. 2014. 66. 202-202
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MATSUMOTO Kohei, KUCHII Shigeru, KAWAHARA Hiroharu. 1P1-C09 Research and Development of Cell's Antibodies Measurement System with Image Processing Technology(Bio Assembler for 3D Cellular System Innovation). 2013. 2013. "1P1-C09(1)"-"1P1-C09(2)"
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川原浩治. ヒト細胞を利用した物質生産,検査技術への応用. 粉体技術. 2013. 5. 5. 445-449
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Patents (13)：
Books (5)：
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動物細胞工学ハンドブック
朝倉書店 2000 ISBN:425443068X
-
Human-human hydridomas producing monoclonal antibodies reactive to house dust mites antigen(共著)
"Animal Cell Technolgy : Challenges for the 21st Century" 1999
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Effects of polysaccharide derved from tea on growth of human cell lines in serum free culture(共著)
"New Developments and New Applications in Animal Cell Technology" 1998
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動物細胞培養技術 (広川化学と生物実験ライン (25))
広川書店 1992 ISBN:4567182502
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無血清細胞培養マニュアル
講談社 1989 ISBN:4061535110
Lectures and oral presentations (24)：
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ガン診断薬への応用を目指した新規ヒト型ナノ抗体の作製
(日本農芸化学会2023年度広島大会 2023)
-
IgE産生抑制作用を有するGAPDH配列の特定
(日本農芸化学会2019年度西日本・中四国支部合同沖縄大会 2019)
-
核内転写因子RORγtのヒトハイブリドーマ抗体産生増強への関与とその応用
(日本動物細胞工学会2019年度大会 2019)
-
T細胞系融合パートナーを用いた細胞融合によるヒトモノクローナル抗体の効率的生産
(平成30年度日本農芸化学会西日本支部大会 2018)
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Establishment of GMP-compliant Human Lymphoid Cell Lines for Production of Therapeutic Proteins
(International Conference of JAACT 2016 2016)
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Education (4)：
- 1987 - 1992 Kyushu University
- - 1992 Kyushu University Graduate School, Division of Agriculture
- 1983 - 1987 Kyushu University School of Agriculture
- - 1987 Kyushu University Faculty of Agriculture
Professional career (1)：
- Doctor (Agriculture) (Kyushu University)
Work history (6)：
Committee career (7)：
Association Membership(s) (4)：
日本動物細胞工学会
, THE JAPANESE CANCER ASSOCIATION
, 日本免疫学会
, 日本農芸化学会
