Hanada Kentaro

ハナダケンタロウ | Hanada Kentaro

Affiliation and department：
Job title： Director
Homepage URL (1)： https://www.niid.go.jp/niid/ja/from-biochem/3257-2013-02-25-06-28-53.html

Research field (3)： Pharmaceuticals - health and biochemistry , Functional biochemistry , Structural biochemistry

Research keywords (9)： Organelle membrane contact , Sphingolipids , Regulatory sciences , Intracellular lipid transport , Ceramide , Vero cells , Infectious pathogens , Mammalian somotaic cell mutants , Biomembrane

Research theme for competitive and other funds (25)：

2021 - 2025 Construction of a new Vero cell system to be the basis for coronavirus research and vaccine development
2017 - 2022 Toward an integrative understanding of functional zones in organelles
2017 - 2022 小胞体膜連携ゾーンを介した脂質輸送
2017 - 2021 Construction of improved virus-susceptible host cells by genome editing
2015 - 2021 病原体による宿主脂質ハイジャック機序の解明と創薬への応用

2015 - 2017 Genomics-based improvement of Vero cells for virus growth

2013 - 2017 Research of the regulatory mechanism of CERT-VAP interaction, from the causing factors to the caused effects.

2013 - 2015 Molecular strategy for the prevention of Chlamydia hijacking of a host lipid transport system

2010 - 2014 Regulatory mechanism of intracellular trafficking of ceramide

2011 - 2012 The regulatory mechanism for the CERT-VAP interaction

2009 - 2010 C型肝炎ウイルスの感染増殖および粒子形成における脂質の役割

2006 - 2009 Determination of phosphorylation sites of the ceramide transport protein CERT, and a role of the phosphorylation

2007 - 2008 Analysis of the role of lipid in viral life cycles

2000 - 2004 細胞内スフィンゴ脂質選別輸送の分子機構と生体膜ドメイン形成にはたす役割

2001 - 2002 The role of host cell membrane lipids in infection of microorganisms and in host defense mechanisms

2000 - 2002 Analysis of membrane lipid sorting by using an in vitro reconstitution system

1998 - 1999 スフィンゴシン塩基生合成の遺伝生化学的研究

1998 - 1998 マラリア原虫の赤血球期における細胞増殖機構の解析

1995 - 1997 genetic and biochemical study on intracellular lipid transport and lipid functions in microdomain

1995 - 1996 A study on cooperative roles of sphingolipids and cholesterol in mammalian cell membranes.

1992 - 1992 スフィンゴ塩基生合成欠損変異を相補するヒトゲノムDNAの単離

1991 - 1991 スフィンゴ脂質の代謝および機能に関する分子遺伝学的研究

1990 - 1990 スフィンゴ脂質の代謝および生理的意義に関する遺伝生化学的研究

1989 - 1989 大腸菌プロリン輸送蛋白における基質および共役カチオン結合部位の解析

1987 - 1987 両機能性融合蛋白を利用した大腸菌プロリン輸送蛋白の精製と再構成

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Papers (214)：

Aya Mizuike, Shota Sakai, Kaoru Katoh, Toshiyuki Yamaji, Kentaro Hanada. The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi. Journal of Cell Biology. 2023. 222. 7
Asako Goto, Kentaro Hanada. Protocol for casein kinase 1γ3 CSNK1G3 gene knockout and recombinant gene expression in cultured HeLa cells. STAR Protocols. 2023. 4. 2. 102251-102251
Charlotte Gehin, Museer A Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi M Adeyemi, Erica H Gerkes, Alexander Pa Stegmann, Estrella López-Martín, Eva Bermejo-Sánchez, et al. CERT1 mutations perturb human development by disrupting sphingolipid homeostasis. The Journal of clinical investigation. 2023. 133. 10
Kenji Someya, Yuko Okemoto-Nakamura, Takako Kurata, Daiki Kanbayashi, Noriko Saito, Masae Itamochi, Noriyuki Otsuki, Kentaro Hanada, Makoto Takeda. Establishment of measles virus receptor-expressing Vero cells lacking functional poliovirus receptors. Microbiology and immunology. 2022. 67. 3. 166-170
Kyoko Saito, Kentaro Shimasaki, Masayoshi Fukasawa, Ryosuke Suzuki, Yuko Okemoto-Nakamura, Kaoru Katoh, Tomohiko Takasaki, Kentaro Hanada. Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon. Virus research. 2022. 322. 198935-198935

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MISC (90)：

藤井汐美, 児玉高志, 杉木俊彦, 花田賢太郎, 藤原敏道, 児嶋長次郎, 児嶋長次郎. Aggregation of the CERT START domain and its prevention. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
水池彩, 酒井祥太, 加藤薫, 山地俊之, 花田賢太郎. C10orf76-PI4KB軸による遠位ゴルジ体へのCERT依存性セラミド輸送の場の構築. 脂質生化学研究. 2023. 65
Kentaro Hanada. Dysregulation of a lipid transfer protein linked to brain disorders. LIPID NEWS, ASBMB TODAY. 2022
後藤麻子, 酒井祥太, 水池彩, 山地俊之, 花田賢太郎. カゼインキナーゼ1γのC末端脂質修飾に依存した細胞内局在変化がスフィンゴミエリン生合成におけるセラミド輸送を制御する. 脂質生化学研究. 2022. 64
水池彩, 酒井祥太, 加藤薫, 山地俊之, 花田賢太郎. Multiple types of ceramide transfer zones are formed between the ER and the Golgi complex. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th

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Education (3)：

1985 - 1988 The University of Tokyo
1983 - 1985 The University of Tokyo
- 1983 The University of Tokyo Faculty of Pharmaceutical Sciences

Professional career (1)：

薬学博士 (東京大学)

Work history (8)：

2021/05 - 現在 National Institute of Infectious Diseases Department of Quality Assurance, Radiation Safety, and Information System Senior Researcher
2006/04 - 2021/03 National Institute of Infectious Diseases Department of Biochemistry and Cell Biology Director
2009/04 - 2012/03 National Institute of Infectious Diseases Division of Quality Assurance Director(concurrent appointment)
1998/04 - 2006/03 National Institute of Infectious Diseases Department of Biochemistry and Cell Biology, Laboratory of Cell Functions Laboratory Chief
1993/04 - 1998/03 National Institute of Infectious Diseases Department of Biochemistry & Cell Biology Senior Researcher

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Committee career (4)：

2022/10 - 現在 Human Disease Genes Website Series Moderator
2020/04 - 2022/03 Pharmaceuticals and Medical Devices Agency (PMDA) Expert Committee
2008/05 - 2021/03 Pharmaceuticals and Medical Devices Agency (PMDA) Expert Committee for GLP Council
2009/01 - 2019/01 Ministry of Health, Labour and Welfare Temporary Member for Japanese Pharmacopoeia Subcommittee

Association Membership(s) (5)：

American Society of Molecular Biolgy and Biochemistry , Biologics Forum , THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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