Rchr
J-GLOBAL ID：200901040179523639
Update date: Apr. 02, 2024
Moribe Kunikazu
モリベ クニカズ | Moribe Kunikazu
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
https://www.p.chiba-u.jp/lab/seizai/
,
https://www.p.chiba-u.jp/lab/seizai/en/index.html
Research field (2)：
Clinical pharmacy
, Pharmaceuticals - analytical and physicochemistry
Research keywords (2)：
製剤工学 Pharmaceutical Technology 物理薬剤学 Physical Pharmacy ドラックデリバリーシステム Drug Delivery System
, Pharmaceutical Technology Physical Pharmacy Drug Delivery System
Research theme for competitive and other funds (20)：
- 2022 - 2025 Development of drug-rich phase-coexisting lipid nanoparticle formulations based on elucidation of molecular mechanism of liquid-liquid phase separation phenomenon of drugs
- 2021 - 2024 Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMR
- 2020 - 2023 Drug dissolution mechanism based on evaluation of polymer structure, mobility, and intermolecular interaction
- 2018 - 2021 Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drug
- 2017 - 2020 Pharmaceutical application of novel lipid nanocarrier bicelle
- 2016 - 2019 Development of drug amorphous/nanocrystal hybrid formulation based on the molecular-level evaluation by solid-state NMR
- 2016 - 2019 Refined structural analysis and mechanical property of drug nano-formulation by AFM in aqueous meida
- 2015 - 2018 Evaluation of molecular state of drug nanosuspensions by suspended-state NMR spectroscopy
- 2013 - 2016 Design of supramolecular complexes to form asymmetry nanotube structure and the application for controlled release carrier
- 2012 - 2015 Structure of supersaturated solution of poorly water-soluble drug indexed by mobility and diffusibility and the correlation with membrane permeability
- 2011 - 2012 Encapsulation of a poorly water-soluble drug with large molecular size into organic nanotube
- 2009 - 2011 Structural evaluation of drug solution by ATR terahertz, NMR, DSC, and viscometry
- 2007 - 2008 Healing of Dacron graft : role of bFGF and extracellular matrix using agarose hydrogel particles as a controlled release reservoir
- 2007 - 2008 Evaluation of molecular states of drug in solid dispersion by terahertz spectroscopy and computational calculation
- 2004 - 2006 混合粉砕法による自己乳化型医薬品封入ナノ微粒子の開発
- 平成30年度 公益財団法人ソルト・サイエンス研究財団 研究助成金 保存した食品中の成分の溶解性・吸収性・安定性に及ぼす塩の影響
- 平成30年度 公益財団法人 日本板硝子材料工学助成会 研究助成金 多孔性シリカを用いた有機・無機ハイブリット機能性薬物放出担体の開発
- 平成28年度 日本食品化学研究振興財団 研究助成金 呈味・フレーバー成分を安定に保持する複合化技術に関する研究
- 平成26年度 ホソカワ粉体工学振興財団 研究助成金 AFM、NMRによる薬物ナノ粒子の構造・凝集性評価
- 平成26年度 上原記念生命科学財団 研究助成金 過飽和製剤処方の最適化及び経口吸収性評価法の確立
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Papers (191)：
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Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Taiji Oyama, Satoko Suzuki, Keisuke Ueda, Kenjirou Higashi, et al. The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles. Pharmaceutics. 2024. 16. 2
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Kazunori Kadota, Tero Kämäräinen, Fumie Sakuma, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Hiromasa Uchiyama, Katsuhiko Minoura, Yuichi Tozuka. Unveiling the flavone-solubilizing effects of α-glucosyl rutin and hesperidin: probing structural differences through NMR and SAXS analyses. Food & function. 2023
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Keisuke Ueda, Yui Sakagawa, Tomoki Saito, Taiki Fujimoto, Misaki Nakamura, Fumie Sakuma, Shun Kaneko, Taisei Tokumoto, Koki Nishimura, Junpei Takeda, et al. Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by 1H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties. Molecular pharmaceutics. 2023. 20. 9. 4729-4742
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Yuta Hatanaka, Hiromasa Uchiyama, Shun Kaneko, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Shingo Furukawa, Mai Takase, Shinya Yamanaka, Kazunori Kadota, et al. Designing a Novel Coamorphous Salt Formulation of Telmisartan with Amlodipine to Enhance Permeability and Oral Absorption. Molecular pharmaceutics. 2023. 20. 8. 4071-4085
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Sudeshna Kundu, Kenjirou Higashi, Makoto Takamizawa, Keisuke Ueda, Kunikazu Moribe. Vapor-Phase-Mediated Encapsulation of Guest Drug Molecules in the Hexagonal Columnar Form Structure of Polyethylene Glycol/γ-Cyclodextrin-Polypseudorotaxane. Crystal Growth & Design. 2023
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MISC (326)：
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東顕二郎, 植田圭祐, 森部久仁一. Solubility improvement of poorly water-soluble drugs by additives~basic theory and introduction of recent study~. Pharm Tech Japan. 2023. 39. 4
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伊藤博光, 伊藤博光, 神田真由美, 真壁宗義, 河合幸紀, 植田圭祐, 東顕二郎, 森部久仁一. Rheological analysis of thickening behavior of drug nanosuspensions. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
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植田圭祐, 菅澤祐昭, 東顕二郎, 森部久仁一. In-situ Characterization of Nano-Formulations by Atomic Force Microscopy (AFM). 製剤機械技術学会誌. 2023. 32. 3
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仲村美咲, 植田圭祐, 東顕二郎, 森部久仁一. Evaluation of molecular state of PEG modified to liposome interface by solution state 1H NMR spectroscopy. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
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佐久間文絵, 植田圭祐, 東顕二郎, 庵原大輔, 平山文俊, 森部久仁一. Effect of acetaminophen incorporation on the property of poloxamer 407 micelle and gel. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
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Works (2)：
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タンパク質医薬品徐放性担体の調製
2002 - 2004
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超臨界流体を用いたナノ粒子の調製
2002 - 2004
Professional career (1)：
- Doctor(Pharmaceutical Sciences) (Chiba University)
Work history (4)：
- 2014 - 現在 Chiba University Graduate School of Pharmaceutical Sciences
- 2008 - 2014 Chiba University Graduate School of Pharmaceutical Sciences
- 2004 - 2008 Chiba University Graduate School of Pharmaceutical Sciences
- 2002 - 2004 Chiba University Graduate School of Pharmaceutical Sciences
Committee career (9)：
- 2014/07 - 現在 千葉県薬事審議会委員(会長)
- - 現在 日局原案審議委員会(製剤委員会)委員
- - 現在 日本DDS学会 評議員
- - 現在 日本シクロデキストリン学会 理事
- - 現在 製剤機械技術学会 理事
- - 現在 粉体工学会 製剤と粒子設計部会 世話人
- 2020/06 - 2022/05 日本薬剤学会会長
- 2016/06 - 2022/05 日本薬剤学会 理事
- 2018/06 - 2020/05 日本薬剤学会副会長
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Awards (2)：
- 2013/05 - 日本薬剤学会旭化成創剤研究奨励賞
- 2008/05 - 日本薬剤学会奨励賞
Association Membership(s) (6)：
シクロデキストリン学会
, 日本DDS学会
, 製剤機械技術学会
, 日本薬剤学会
, 日本薬学会
, 粉体工学会 製剤と粒子設計部会
