Karasuyama Hajime

カラスヤマハジメ | Karasuyama Hajime

Affiliation and department：
Job title： Deputy Director
Homepage URL (2)： http://immune-regulation.org/ , http://immune-regulation.org/index.php?id=27

Research field (3)： Allergies and connective tissue disease , Cell biology , Immunology

Research keywords (6)： infection , Infection , immunodeficiency , B cell development , basophil , allergy

Research theme for competitive and other funds (64)：

2022 - 2025 好塩基球を起点とした慢性アレルギー炎症誘導カスケードの解明
2021 - 2024 急性呼吸窮迫症候群(ARDS)の炎症制御機構の解明と新規治療戦略への展開
2021 - 2023 急性呼吸窮迫症候群(ARDS)の炎症制御機構の解明と新規治療戦略への展開
2019 - 2022 Physiological and pathological roles of basophils
2019 - 2021 好塩基球の生理的・病的役割の解明

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Papers (313)：

Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Frank Brombacher, Shigeyuki Shichino, Soichiro Yoshikawa, Sachiko Miyake, Hajime Karasuyama. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. Nature communications. 2024. 15. 1. 1666-1666
高澤聖子, 三宅健介, 杉原潤, 柴田翔, 立石知也, 烏山一, 宮崎泰成. 増悪と抑制を司るアレルギーメディエーター好塩基球由来IL-4は急性呼吸促迫症候群モデルの肺炎症を抑制する. アレルギー. 2023. 72. 6-7. 909-909
Kensuke Miyake, Junya Ito, Jun Nakabayashi, Shigeyuki Shichino, Kenji Ishiwata, Hajime Karasuyama. Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils. Nature communications. 2023. 14. 1. 2694-2694
Takashi Hashimoto, Hiroo Yokozeki, Hajime Karasuyama, Takahiro Satoh. IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin. The Journal of allergy and clinical immunology. 2022
Kenichi Inaba, Masaaki Higashiyama, Chikako Watanabe, Akira Tomioka, Suguru Ito, Rina Tanemoto, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Nao Sugihara, et al. Basophils play a proinflammatory role in oxazolone-induced chronic intestinal inflammation. Journal of gastroenterology and hepatology. 2022

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MISC (233)：

三宅健介, 烏山一. 【ファゴサイトーシスとトロゴサイトーシス】免疫細胞におけるトロゴサイトーシスの役割. 臨床免疫・アレルギー科. 2022. 77. 2. 168-175
三宅健介, 烏山一. 【肺免疫から肺疾患を考える】アレルギー疾患や寄生虫感染症における好塩基球の役割. 呼吸器内科. 2021. 40. 6. 535-542
三宅健介, 烏山一. いま知りたい!!かじる?呑み込む?貪食の多様性トロゴサイトーシスとエフェロサイトーシストロゴサイトーシスによる免疫細胞機能の調節. 実験医学. 2021. 39. 14. 2229-2232
柴田翔, 三宅健介, 立石知也, 烏山一, 宮崎泰成. 好酸球と好塩基球の活性化メカニズムマウス,ヒトにおいて好中球エラスターゼは好塩基球からのIL-4分泌を促進する. アレルギー. 2021. 70. 6-7. 799-799
岸本泉, 馬尼, 谷崎英昭, 中嶋千紗, 大塚篤司, 三宅健介, 烏山一, 神戸直智. 好酸球と好塩基球の活性化メカニズム蕁麻疹の活動期に見られる好塩基球減少に関する動物モデルからの検証. アレルギー. 2021. 70. 6-7. 799-799

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Books (2)：

呼吸器疾患診断治療アプローチ気管支喘息
中山書店 2017 ISBN:9784521745251
エッセンシャル免疫学第3版(The Immune System, 4th edition)
株式会社メディカル・サイエンス・インターナショナル 2016 ISBN:9784895928649

Lectures and oral presentations (198)：

皮膚アレルギー炎症における好塩基球の役割
(第50回日本皮膚免疫アレルギー学会総会学術大会 2020)
Basophils present antigens to T cells via trogocytosis-mediated acquisition of MHC class II
(第43回日本分子生物学会年会(MBSJ2020) 2020)
アトピー性皮膚炎病態形成における好塩基球由来IL-4の役割
(第48回日本臨床免疫学会総会 2020)
Identification of two distinct subpopulations among basophils in the bone marrow
(JSA/WAO Joint Congress 2020 2020)
Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation
(JSA/WAO Joint Congress 2020 2020)

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Education (2)：

1980 - 1984 The University of Tokyo Graduate School of Medicine
1972 - 1978 Tokyo Medical and Dental University Faculty of Medicine

Professional career (1)：

MD., PhD. (The University of Tokyo)

Work history (20)：

2021/02/01 - 現在 Tokyo Medical and Dental University Deputy Director
2019/04/01 - 現在 Tokyo Medical and Dental University Distinguished Professor
2019/04 - 現在 Tokyo Medical and Dental University TMDU Advanced Research Institute Distinguished Professor
2020/10/01 - 2021/01/31 Tokyo Medical and Dental University Deputy Director
2014/04 - 2020/03 Tokyo Medical and Dental University Board Member Executive Director

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Committee career (5)：

Japanese Society of Allergology Councilor
Japanese Society for Immunology Board member
日本アレルギー学会代議員
日本免疫学会理事、評議員
Japanese Society of Allergology Board of representatives

Awards (9)：

2014/10 - Tokyo Medical and Dental University Tokyo Medical and Dental University President Award (Hajime Karasuyama)
2014/04 - Ministry of Education, Culture, Sports, Science and Technology The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and Technology (Research Category) (Hajime Karasuyama)
2014 - Minister of Education, Culture, Sports, Science and Technology The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and Technology (Research Category)
2010/03 - 上原記念生命科学財団上原記念生命科学財団研究助成好塩基球の生体内での役割・存在意義の解明
2010/03 - 内藤記念科学振興財団内藤記念科学振興財団科学奨励賞好塩基球の生理機能と病態形成における役割の解明

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Association Membership(s) (6)：

The American Association of Immunologists , Japanese Society of Hematology , Japanese Cancer Association , The Molecular Biology Society of Japan , Japanese Society of Allergology , Japanese Society for Immunology

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