Tsumiyama Ken

ツミヤマケン | Tsumiyama Ken

Affiliation and department：
Job title： Chief Scientist
Other affiliations (1)：

Matsubara Mayflower Hospital Research Division Scientist

Homepage URL (1)： http://irdbio.co.jp

Research field (4)： Molecular biology , Cell biology , Allergies and connective tissue disease , Immunology

Research keywords (6)： systemic lupus erythematosus , autoimmunity , autoantibody , T cell , immunology , rheumatology

Research theme for competitive and other funds (4)：

2018 - 2021 Studies on the induction of pathogenic T cell by endoplasmic reticulum stress and the pathogenesis of systemic lupus erythematosus
2016 - 2019 Studies on the pathogenesis of systemic lupus erythematosus mediated by endoplasmic reticulum stress and antigen cross-presentation
2014 - 2016 Studies on the mechanism of the induction of systemic lupus erythematosus mediated via antigen cross-presentation
2008 - 2010 Sleep disturbance and related changes of circadian rhythm in patients with rheumatoid arthritis.

Papers (19)：

Shinya Hayashi, Tsukasa Matsubara, Toshihisa Maeda, Koji Fukuda, Keiko Funahashi, Marowa Hashimoto, Ken Tsumiyama, Tomoyuki Kamenaga, Yoshinori Takashima, Tomoyuki Matsumoto, et al. Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment. Scientific reports. 2022. 12. 1. 17524-17524
Marowa Hashimoto, Keiko Funahashi, Ken Tsumiyama, Yoshinori Takashima, Toshihisa Maeda, Koji Fukuda, Shinya Hayashi, Ryosuke Kuroda, Tsukasa Matsubara. OASL rs10774580 SNP is associated with Herpes Zoster infection in rheumatoid arthritis. Rheumatology: Current Research. 2022. 12. 5. 1000312
Shunichi Shiozawa, Ken Tsumiyama, Yumi Miyazaki, Kenichi Uto, Keiichi Sakurai, Toshie Nakashima, Hiroko Matsuyama, Ai Doi, Miho Tarui, Manabu Izumikawa, et al. DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus. iScience. 2022. 25. 1. 103537
Chieri Akiyama, Ken Tsumiyama, Chiaki Uchimura, Eriko Honda, Yumi Miyazaki, Keiichi Sakurai, Yasushi Miura, Akira Hashiramoto, Dean W Felsher, Shunichi Shiozawa. Conditional Upregulation of IFN-α Alone Is Sufficient to Induce Systemic Lupus Erythematosus. Journal of immunology. 2019. 203. 4. 835-843
Akira Hashiramoto, Yoshitake Konishi, Koichi Murayama, Hiroki Kawasaki, Kohsuke Yoshida, Ken Tsumiyama, Kimie Tanaka, Masaru Mizuhara, Toshio Shiotsuki, Hitomi Kitamura, et al. A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell. Journal of Biological Chemistry. 2018. 293. 6. 1933-1943

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MISC (198)：

林申也, 松原司, 前田俊恒, 福田康治, 舟橋恵子, 橋本麿和, 積山賢, 立花章太郎, 黒田良祐. IL-6阻害薬は骨びらんによる関節破壊の進行を優位に抑制する. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2023. 67回. 603-603
尾ノ井勇磨, 菊池健一, 前田俊恒, 林申也, 安喰健祐, 生田健明, 立花章太郎, 橋本麿和, 積山賢, 舟橋恵子, et al. 多剤耐性マーカーMDR1遺伝子がJAK阻害薬の治療効果に与える影響について. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2023. 67回. 708-708
安喰健祐, 林申也, 前田俊恒, 菊池健一, 藤田雅広, 生田健明, 尾ノ井勇磨, 立花章太郎, 福田康治, 積山賢, et al. IL-6刺激下でのJAK阻害剤の血管新生抑制効果の比較検討. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2023. 67回. 774-774
生田健明, 林申也, 前田俊恒, 菊池健一, 藤田雅広, 安喰健祐, 尾ノ井勇磨, 立花章太郎, 福田康治, 積山賢, et al. RA患者由来線維芽細胞様滑膜細胞へのIL-6・TNFα刺激に対するJAK阻害剤の炎症抑制効果の比較検討. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2023. 67回. 873-873
立花章太郎, 林申也, 前田俊恒, 菊池健一, 藤田雅広, 安喰健祐, 生田健明, 尾ノ井勇磨, 福田康治, 積山賢, et al. 軟骨細胞へのIL-6刺激に対するJAK阻害剤の効果. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2023. 67回. 873-873

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Patents (4)：

Lectures and oral presentations (50)：

抗原のクロスプレゼンテーションによる全身性エリテマトーデス(SLE)組織傷害の誘導機構
(第3回病因研究会別府シンポジウム 2017)
「自己臨界点説」による全身性エリテマトーデス(SLE)の発症病因の解明
(第24回翠嶂会セミナー 2016)
膠原病における組織傷害の誘導機構
(第3回JCRベーシックリサーチカンファレンス次世代リーダーセッション 2016)
全身性エリテマトーデス(SLE)における組織傷害の誘導機構
(第2回病因研究会別府シンポジウム 2016)
Sec61を介した抗原のクロスプレセンテーションはSLEの組織傷害を引き起こす
(第2回JCRベーシックリサーチカンファレンス 2015)

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Education (2)：

- 2010 Kobe University Graduate School of Medicine Department of Health Sciences
- 2003 Okayama University Faculty of Engineering Department of Bioscience and Biotechnology

Professional career (1)：

Ph.D. (Kobe University)

Work history (8)：

2020/07 - 現在 Matsubara Mayflower Hospital Research Division Scientist
2018/04 - 現在 Institute for Rheumatic Diseases Research Division Chief Scientist
2013/07 - 2018/03 Kyushu University Beppu Hospital Department of Medicine, Rheumatic Diseases Unit Assistant Professor
2012/04 - 2013/06 Kyushu University Beppu Hospital Department of Medicine Research Assistant Professor
2010/10 - 2012/03 Kobe University Graduate School of Health Sciences Assistant Professor

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Committee career (1)：

2013 - 現在 Japan College of Rheumatology councilor

Association Membership(s) (2)：

JAPANESE SOCIETY FOR IMMUNOLOGY , JAPAN COLLEGE OF RHEUMATOLOGY

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