Rchr
J-GLOBAL ID：200901040326697702   Update date: Apr. 01, 2024

Ishisaki Akira

イシサキ アキラ | Ishisaki Akira
Affiliation and department：
Iwate Medical University Division of Cellular Biosignal Sciences, Department of Biochemistry

About Iwate Medical University Division of Cellular Biosignal Sciences, Department of Biochemistry


Job title： Professor
Homepage URL  (1)： http://cellbiosignal.jp/
Research field  (1)： Oral medicine
Research keywords  (9)： 分子生物学 ,  細胞生物学 ,  口腔生化学 ,  生化学 ,  Molecular Biology ,  Biochemistry ,  Differentiation ,  Cell ,  Periodontal Tissue
Research theme for competitive and other funds  (38)：
  • 2023 - 2027 口腔扁平上皮癌細胞の癌微小環境における細胞外小胞を介した浸潤・転移誘導機構の解明
  • 2021 - 2024 Clarification of and treatment strategy for intractable soft and hard tissue diseases based on control of macrophage polarization
  • 2020 - 2024 間葉系幹細胞の抗炎症性免疫細胞誘導能を応用した変形性顎関節症新規治療戦略の確立
  • 2020 - 2023 Elucidation of molecular mechanisms underlying invasion and metastasis of oral cancer cells controlled by mesenchymal stem cells
  • 2017 - 2020 Elucidation of molecular mechanism underlying EMT/MET in oral squamous cell carcinoma cells
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Papers (134)：
  • Hironori Yoshida, Seiji Yokota, Kazuro Satoh, Akira Ishisaki, Naoyuki Chosa. Connective tissue growth factor enhances TGF-β1-induced osteogenic differentiation via activation of p38 MAPK in mesenchymal stem cells. Journal of Oral Biosciences. 2024. 66. 1. 68-75
  • Nanami Obara, Seiko Kyakumoto, Satoshi Yamaguchi, Hiroyuki Yamada, Akira Ishisaki, Masaharu Kamo. Disruption of CADM1-dependent cell-cell adhesion in human oral squamous cell carcinoma cells results in tumor progression, possibly through an increase of MMP-2 and MMP-9 expression. Journal of Oral Biosciences. 2024. 66. 151-159
  • Kanna Asanuma, Seiji Yokota, Naoyuki Chosa, Masaharu Kamo, Miho Ibi, Hisayo Mayama, Tarou Irié, Kazuro Satoh, Akira Ishisaki. Hydrogen peroxide-induced oxidative stress promotes expression of CXCL15/Lungkine mRNA in a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint. J Oral Biosci. 2023. 65. 1. 97-103
  • Seiji Yokota, Naoyuki Chosa, Shikino Matsumoto, Kazuro Satoh, Akira Ishisaki. Extracellular adenosine 5ʹ-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes. Mol Biol Rep. 2023. 50. 2. 1595-1602
  • Miyamae Y, Ohta M, Sato K, Ishisaki A, Chosa N. TGF-β1-induced IL-6 expression via MEK pathway in mesenchymal stem cells enhances NGF-dependent neurite extension in PC12 cells. Dent J Iwate Med Univ. 2022. 47. 1. 19-33
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MISC (150)：
  • TGF- β abrogated the LPS-induced activation of NF-κ B-medicated signal that relayed suppressive effect on the osteogenic activity in human mesenchymal stem cells. 2021. 46. 2. 107-108
  • 浅沼莞奈, 横田聖司, 帖佐直幸, 松本識野, 間山寿代, 石崎明, 佐藤和朗. Effect of oxidative stress on chemokine expression in fibroblast-like synoviocytes derived from mouse temporomandibular joint. 日本矯正歯科学会大会プログラム・抄録集. 2021. 80th
  • 武田啓, 武田啓, 石川雄大, 石川雄大, 山田浩之, 石崎明, 加茂政晴. 腫瘍関連マクロファージはヒト口腔扁平上皮癌細胞におけるCXCL14の発現を抑制しTGF-β1誘発EMTを促進する。. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
  • 横田聖司, 帖佐直幸, 松本識野, 客本斎子, 加茂政晴, 石崎明. 顎関節由来線維芽細胞様滑膜細胞におけるケモカイン発現へのeATPの影響. 日本生化学会大会(Web). 2020. 93rd
  • 相原 恵子, 帖佐 直幸, 石崎 明, 八重柏 隆. 間葉系幹細胞による炎症調節メカニズムの解明. 岩手医科大学歯学雑誌. 2019. 44. 1. 26-27
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Books (6)：
  • Oral Bioscience (6th Edition)
    Ishiyaku Publishers, Inc. 2018
  • Angiogenic capacity of periodontal ligament-derived stem cells. [Advances in oral tissue engineering. Murata M. & Um IW. (ed.)]
    Quintessence Publishing 2014
  • Interface oral health science 2011.
    Springer, New York 2012
  • Oral Biochemistry (5th Edition)
    Ishiyaku Publishers. Inc. 2011
  • 血管内皮細胞研究フロンティア(共著)
    メディカルレビュー社 2004
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Lectures and oral presentations  (68)：
  • Establishment of novel strategy of regenerative medicine with mesenchymal stem cells
    (The 57th Annual Meeting of Japan Tissue Culture Society for Dental Research 2021)
  • Effect of ADP on chemokine expression in fibrogenic phenotype of synoviocytes derived from mouse temporomandibular joint
    (The 94th Annual Meeting of the Japanese Biochemical Society 2021)
  • CCL20 suppresses CXCL14 expression, which is upregulated by TGF-β1/Smad signaling pathway, through ERK/Akt signaling pathway in human oral squamous cell carcinoma cells HSC-4
    (The 43rd Annual Meeting of the Molecular Society of Japan 2020)
  • Establishment of efficient method for mass preparation of immunosuppressive macrophages from peripheral blood for cell-based therapy against periodontitis
    (The 63rd Autumn Meeting of the Japanese Society of Periodontology 2020)
  • Effect of ATP on chemokine expression in fibrogenic phenotype of synoviocytes derived from mouse temporomandibular joint
    (The 93rd Annual Meeting of the Japanese Biochemical Society 2020)
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Education (3)：
  • 1989 - 1993 Tokyo Medical and Dental University Graduate School of Dental Medicine Study of Oral and Maxillofacial Surgery
  • 1988 - 1989 Tokyo Medical and Dental University Faculty of Dentistry Clinical Staff of Department of Oral and Maxillofacial Surgery I
  • 1982 - 1988 Tokyo Medical and Dental University Faculty of Dentistry School of Dentistry
Professional career (1)：
  • PhD (Dentistry) (Tokyo Medical and Dental University)
Work history (9)：
  • 2011/04 - 現在 Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University Professor
  • 2008/07 - 2011/03 Department of Oral Biochemistry, Faculty of Dentistry, Iwate Medical University Professor
  • 2005/04 - 2008/06 Division of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University Associate Professor
  • 2003/08 - 2005/03 Department of Pharmacology, Gifu University Graduate School of Medicine Instructor
  • 2003/06 - 2003/07 Department of Pharmacology, Gifu University Graduate School of Medicine Assistant Professor
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Committee career (18)：
  • 2021/05 - 現在 International Journal of Oncology Editorial Academy member
  • 2021/04 - 現在 Frontiers in Dental Medicine Review Editor
  • 2019/10 - 現在 Experimental and Therapeutic Medicine Editorial Board member
  • 2019/04 - 現在 Molecular Medicine Reports Editorial Board member
  • 2016/04 - 現在 Editor-in-Chief Dental Journal of Iwate Medical University
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Awards (2)：
  • 2021/11 - The Japanese Tissue Culture Society for Dental Research Society Award from the Japanese Tissue Culture Society for Dental Research
  • 1994 - The Fellowship from The Japan-Sweden Foundation
Association Membership(s) (9)：
The Stomatological Society, Japan ,  Japan Tissue Culture Society for Dental Research ,  Iwate Association for Dental Science ,  Hokkaido Association for Dental Science ,  The Japanese Dental Education Association ,  The Japanese Pharmacological Society ,  The Japanese Biochemical Society ,  The Molecular Biology Society of Japan ,  The Japanese Association for Oral Biology
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