Tonami Kazuo

トナミカズオ | Tonami Kazuo

Affiliation and department：
Other affiliations (1)：

The University of Tokyo Faculty of Medicine

Homepage URL (1)： http://bio.m.u-tokyo.ac.jp/index.html

Research field (5)： Morphology, anatomy , Developmental biology , Cell biology , Molecular biology , Anatomy

Research keywords (12)： Developmental Biology , Regenerative medicine , 再生医学 , 発生学 , 形態形成 , 細胞運動制御 , 細胞骨格 , カルパイン , muscule developoment , cell motility , cytoskeletal organiazation , calpain

Research theme for competitive and other funds (8)：

2021 - 内皮細胞固有の細胞動態を生み出す遺伝子の再構成による非血管細胞からの血管構造誘導の試み
2018 - 2021 内皮細胞の運動特性を基盤とする血管新生のメカニズムの解明
2014 - 2016 受容体分子UNC5Dによる発生期大脳皮質における移動神経細胞の制御機構の解析
2015 - 2016 Functional analysis of non-proteolytic calpain to the skeletal muscle development via RhoA activity
2011 - 2015 Tissue-specific functional studies on calpains

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Papers (13)：

Kazuma Sakai, Tatsuya Hayashi, Yusuke Sakai, Jun Mada, Kazuo Tonami, Yasunobu Uchijima, Hiroki Kurihara, Tetsuji Tokihiro. A three-dimensional model with two-body interactions for endothelial cells in angiogenesis. Scientific Reports. 2023. 13. 1
Haruhisa Oda, Kazuo Tonami, Yoichi Nakata, Naoko Takubo, Hiroki Kurihara. Persistent homological cell tracking technology. Scientific Reports. 2023. 13. 1
Kazuo Tonami, Tatsuya Hayashi, Yasunobu Uchijima, Masahiro Kanai, Fumitaka Yura, Jun Mada, Kei Sugahara, Yukiko Kurihara, Yuri Kominami, Toshiyuki Ushijima, et al. Coordinated Linear and Rotational Movements of Endothelial Cells Compartmentalized by VE-cadherin Drive Angiogenic Sprouting. iScience. 2023. 26. 7. 107051-107051
Yuichiro Arima, Yoshiko Nakagawa, Toru Takeo, Toshifumi Ishida, Toshihiro Yamada, Shinjiro Hino, Mitsuyoshi Nakao, Sanshiro Hanada, Terumasa Umemoto, Toshio Suda, et al. Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation. Nature Metabolism. 2021. 3. 2. 196-210
Takuro Miyazaki, Kazuo Tonami, Shoji Hata, Toshihiro Aiuchi, Koji Ohnishi, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Motohiro Takeya, Hiroyuki Itabe, Hiroyuki Sorimachi, et al. Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. JOURNAL OF CLINICAL INVESTIGATION. 2016. 126. 9. 3417-3432

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MISC (4)：

Hiroki Kurihara, Jun Mada, Tetsuji Tokihiro, Kazuo Tonami, Toshiyuki Ushijima, Fumitaka Yura. Angiogenesis: Dynamics of Endothelial Cells in Sprouting and Bifurcation. Theoretical Biology. 2022. 25-83
劉瀟瀟, 礪波一夫, 林達也, 内島泰信, 栗原裕基. 血管新生におけるFAT1の機能解析. 日本血管生物医学会学術集会プログラム・抄録集. 2022. 30th (CD-ROM)
劉瀟瀟, 礪波一夫, 林達也, 内島泰信, 栗原裕基. Analysis of FAT1 of Endothelial cell in angiogenic morphogenesis. 高血圧関連疾患モデル学会学術総会抄録集. 2021. 57th (CD-ROM)
礪波一夫, 栗原由紀子, 小野弥子, 秦勝志, 尾嶋孝一, 栗原裕基, 反町洋之. 胎児筋特異的に発現する新規カルパインの病態生理における役割の解析. 日本病態プロテアーゼ学会 J.S.P.P. News Letter,. 2013. 29. 11-12

Lectures and oral presentations (31)：

The novel mechanism of angiogenesis based on unique behaviors of endothelial cell
(The 45th Annual Meeting of the Molecular Biology Society of Japan 2022)
Identification of characteristic behaviors of endothelial cells as a fundamental process of angiogenesis
(CVEM2022 2022)
Analysis of molecular mechanisms underlying contact-dependent rotational movement of endothelial cells
(Cardiovascular and Metabolic Week 2020 (28th Annual Meeting of the Japanese Vascular Biology and Medicine Organization) 2021)
Analysis of patterns and mechanisms of endothelial behaviors in angiogenic morphogenesis
(The 42nd Annual Meeting of the Molecular Biology Society of Japan 2019)
Analysis of endothelial cell behaviors as a fundamental process of angiogenesis and molecular mechanism underlying their regulation
(2018)

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Education (6)：

- 2008 The University of Tokyo
- 2008 The University of Tokyo Graduate School, Division of Medical Sciences Biochemistry and Molecular Biology
- 2004 The University of Tokyo
- 2004 The University of Tokyo Graduate School, Division of Medical Sciences Medical Science
- 2002 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy

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Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (12)：

2023/06 - 現在 The University of Tokyo Faculty of Medicine
2023/04 - 現在 Japan Science and Technology Agency
2016/01 - 2023/03 The University of Tokyo Graduate School of Medicine
2015/04 - 2015/12 The University of Tokyo Graduate School of Medicine
2014/04 - 2015/03 Keio University School of Medicine, Department of Anatomy

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Committee career (5)：

2022/12 - 2023/03 THE JAPANESE VASCULAR BIOLOGY AND MEDICINE ORGANIZATION Committee
2022/04 - 2023/03 THE JAPANESE VASCULAR BIOLOGY AND MEDICINE ORGANIZATION Deputy Secretary General
2018/04 - 2023/03 日本血管生物医学会評議員
2016/01 - 2023/03 Blood Vessel Club 運営委員
2007/06 - 2008/03 生体シグナルを基盤とする統合生命学第1回グローバルCOEリトリート学生委員長(平成19年度)

Awards (5)：

2017/12 - The Japanese Vascular Biology and Medicine Organization Young Investigators Award Excellence
2013/11 - 公益財団法人東京都医学総合研究所平成25年度東京都医学総合研究所ポスター発表会優秀賞非プロテアーゼ型カルパインCAPN6の筋組織発生・再生における新規生理機能の同定
2011/09 - 日本生化学会第84 回日本生化学会大会鈴木紘一メモリアル賞
2011/08 - 日本病態プロテアーゼ学会第16 回日本病態プロテアーゼ学会学術集会 Young Investigators Award
2009 - 第82回日本生化学会大会優秀プレゼンテーション賞

Association Membership(s) (8)：

The Society of Cardiovascular Endocrinology and Metabolism , The Japan Neuroscience Society , 日本病態プロテアーゼ学会 , 日本細胞生物学会 , 日本発生生物学会 , 日本血管生物医学会 , 日本生化学会 , 日本分子生物学会

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