Takahashi Toshio

タカハシトシオ | Takahashi Toshio

Affiliation and department：
Job title： Chief Researcher
Homepage URL (1)： http://www.sunbor.or.jp/

Research field (3)： Developmental biology , Cell biology , Animals: biochemistry, physiology, behavioral science

Research keywords (9)：幹細胞 , Organoid , gut , アセチルコリン , 刺胞動物 , 生理活性ペプチド , Octopus , Hydra , Bioactive peptide

Research theme for competitive and other funds (10)：

2023 - 2026 腸幹細胞の幹細胞性を支えるアセチルコリンシグナリングの解明
2020 - 2023 非神経細胞型アセチルコリン受容体を介した腸幹細胞の分化・増殖制御機構の解明
2017 - 2020 非神経性アセチルコリンによる腸幹細胞の分化・増殖、維持機構の解明
2013 - 2016 Effects of iron chelator nicotianamine from plant food on iron absorption in intestine
2006 - 2008 ヒドラの生体制御に関与するペプチド性シグナル分子とその受容体の網羅的解析

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Papers (86)：

Tsubasa Sakai, Tatsuya Yamamoto, Takehiro Watanabe, Akiko Hozumi, Akira Shiraishi, Tomohiro Osugi, Shin Matsubara, Tsuyoshi Kawada, Yasunori Sasakura, Toshio Takahashi, et al. Characterization of a novel species-specific 51-amino acid peptide, PEP51, as a caspase-3/7 activator in ovarian follicles of the ascidian, Ciona intestinalis Type A. Frontiers in Endocrinology. 2023. 14
Tohru Yamagaki, Tsukiho Osawa, Kohki Fujikawa, Takehiro Watanabe, Kohtaro Sugahara. Multimatrix Variation Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry as a Tool for Determining the Bonding of Nitrogen Atoms in Alkaloids. Journal of the American Society for Mass Spectrometry. 2022. 33. 12. in press-2249
Jun Murata, Takehiro Watanabe, Hajime Komura. Bacterial Volatile Isovaleric Acid Triggers Growth Alteration of Arabidopsis Seedlings. Metabolites. 2022. 12. 1043
Saori Ohmae, Sota Akazawa, Toshio Takahashi, Takayuki Izumo, Tomohiro Rogi, Masaaki Nakai. Quercetin attenuates adipogenesis and fibrosis in human skeletal muscle. Biochem. Biophys. Res. Commun. 2022. 615. 24-30
Toshio Takahashi, Kazuto Fujishima, Mineko Kengaku. Modeling Intestinal Stem Cell Function with Organoids. International Journal of Molecular Sciences. 2021. 22. 20. 10912-10912

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MISC (9)：

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Books (13)：

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Lectures and oral presentations (39)：

腸の活発な再生・分化を支える非神経性アセチルコリンシグナリング
(第46回日本比較内分泌学会大会及びシンポジウム 2022)
Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling
(2022)
The coordinated activities of nAChR and Wnt signaling regulate intestinal stem cell function in mice
(日本比較生理生化学会第41回東京大会 2019)
The α2β4 nicotinic acetylcholine receptor controls intestinal stem cell proliferation and differentiation in mice
(5th International Symposium on Non-neuronal Acetylcholine: from bench to bedside 2019)
Structure and function of Hydra neuropeptides
(The 10th International Congress of Comparative Physiology and Biochemistry (ICCPB2019, Ottawa, Canada, 8.5-8.9, 2019) 2019)

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Education (5)：

1994 - 1997 Hiroshima University Graduate School of Biosphere Science
- 1997 Hiroshima University Graduate School, Division of Biophere Sciences Biology
1992 - 1994 Hiroshima University Graduate School of Biosphere Science
1988 - 1992 Hiroshima University Faculty of Science
- 1992 Hiroshima University Faculty of Science Zoological Institute・Biological Science

Professional career (1)：

Work history (5)：

Committee career (7)：

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Awards (2)：

2014/07 - 4th International Symposium on Non-neuronal Acetylcholine Best Short Oral Presentation Award
2010/07 - 日本比較生理生化学会吉田奨励賞

Association Membership(s) (4)：

日本比較生理生化学会 , 日本発生生物学会 , 日本動物学会 , 日本小腸学会

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