Rchr
J-GLOBAL ID：200901041450780584   Update date: Apr. 18, 2024

TOSHIO SUDA

スダ トシオ | TOSHIO SUDA
Affiliation and department：
National University of Singapore Cancer Science Institute

About National University of Singapore Cancer Science Institute


Job title： Senior Principal Investigator・Professor
Other affiliations (1)：
Research field  (1)： Hematology and oncology
Research theme for competitive and other funds  (85)：
  • 2020 - 2023 胃癌間質の組織型別分子サブタイピングに基づいた抗ストローマ治療戦略の開発
  • 2018 - 2023 Self-renewal capacity of hematopoietic stem cells and mitochondrial metabolism
  • 2019 - 2022 Metabolic and epigenetic regulation of pluripotency via FLCN-RAG-TFE axis
  • 2018 - 2021 Cell metabolism determines the megakaryocyte lineage fate of hematopoietic stem cells
  • 2016 - 2019 Regulation of preimplantation embryonic fate and plasticity by the PRC1 Polycomb group complex
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Papers (227)：
  • Wenjuan Ma, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Ahad Khalilnezhad, Miho Kataoka, Yuichiro Arima, Yosuke Tanaka, Shigeru Yanagi, Terumasa Umemoto, Toshio Suda. MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response. The EMBO Journal. 2024. 43. 3. 339-361
  • Wenjuan Ma, Yuichiro Arima, Terumasa Umemoto, Tomomasa Yokomizo, Yuqing Xu, Kenichi Miharada, Yosuke Tanaka, Toshio Suda. Metabolic regulation in erythroid differentiation by systemic ketogenesis in fasted mice. Experimental hematology. 2023
  • Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Yuxin Wang, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa. Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells. Cancer science. 2023
  • Sahoko Matsuoka, Raffaella Facchini, Tiago C Luis, Joana Carrelha, Petter S Woll, Takuo Mizukami, Bishan Wu, Hanane Boukarabila, Mario Buono, Ruggiero Norfo, et al. Loss of endothelial membrane KIT Ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells. Blood. 2023
  • Keiyo Takubo, Phyo Wai Htun, Takeshi Ueda, Yasuyuki Sera, Masayuki Iwasaki, Miho Koizumi, Kohei Shiroshita, Hiroshi Kobayashi, Miho Haraguchi, Shintaro Watanuki, et al. MBTD1 preserves adult hematopoietic stem cell pool size and function. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 32. e2206860120
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MISC (155)：
  • 田中洋介, 田中洋介, 福島剛, 小出周平, 合山進, 岩間厚志, 須田年生, 北村俊雄. The hematopoietic stem cell picture based on their division patterns. 日本再生医療学会総会(Web). 2023. 22nd
  • 森嶋達也, 高橋康一, LOON Chin Desmond Wai, 徳永賢治, 松岡雅雄, 須田年生, 須田年生, 滝澤仁. Drug resistant mechanism via lipid metabolism adaptation in acute myeloid leukemia with IDH2 gene mutation. 臨床薬理の進歩. 2022. 43
  • Wenjuan Ma, Takanobu Motoshima, Shintaro Funasaki, Yorifumi Satou, Benjy J. Y. Tan, Hisashi Hasumi, Mitsuko Furuya, Masahiro Yao, W. Marston Linehan, Yuichi Oike, et al. Regulation of hypoxia response pathway by chimeric TFE3s in Xp11.2 translocation renal cell carcinoma. CANCER SCIENCE. 2021. 112. 457-457
  • 森嶋達也, 森嶋達也, CHIN Desmond, 高橋康一, 有田誠, 有田誠, 有田誠, 徳永賢治, 松岡雅雄, 須田年生, et al. アラキドン酸低下を介したIDH関連オンコメタボライト非依存性AML細胞増殖. 日本血液学会学術集会抄録(Web). 2020. 82nd
  • 古賀沙緒里, 鶴田真理子, 荒木愛, 權藤大輝, 須田年生, 横溝智雅, 小川峰太郎. シングルセルRNA-seqを用いた造血幹細胞の発生過程の解明. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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Books (5)：
  • 実験医学22巻3号
    東京:羊土社 2004
  • Annual Review 血液2004
    東京:中外医学社 2004
  • 炎症と免疫12巻1号
    東京:先端医学社 2004
  • 日本医事新報4141号
    東京:日本医事新報社 2003
  • 日本医事新報 4128号95
    東京:日本医事新報社 2003
Lectures and oral presentations  (56)：
  • Mitochondrial metabolism in HSCs
    (University of Columbia, Seminar 2019)
  • Mitochondrial metabolism in HSCs
    (16th Nikko International symposium 2019)
  • Mitochondria Metabolism in Quiescent and Cycling Hematopoietic Stem Cells
    (48th Annual Scientific meeting ISEH 2019)
  • Quiescence and cell metabolism in stem cells
    (Japan-Singapore International Skin Conference 2019)
  • Mitochondrial metabolism in hematopoietic stem cells
    (US-Japan Symposium on Normal/malignant hematopoiesis and novel therapies for hematologic malignancies 2019)
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Professional career (1)：
  • 医学博士 (自治医科大学)
Work history (10)：
  • 2015 - 現在 Kumamoto University International Research Center for Medical Sciences Director and Distinguished Professor
  • 2015 - 現在 National University of Singapore Cancer Science Institute of Singapore Professor
  • 2002 - 2015 Keio University School of Medicine Developmental Biology, The Sakaguchi Laboratory Professor
  • 1992 - 2001 Kumamoto University School of Medicine Institute of Molecular Embryology and Genetics, Department of Cell Differentiation Professor
  • 1991 - Jichi Medical School Department of Medicine, Division of Hematology Associate Professor
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Committee career (1)：
  • 2003/10/02 - 2006/10/20 日本学術会議 委員
Awards (8)：
  • 2020/12 - 62nd American Society of Hematology The E. Donnall Thomas Lecture and Prize
  • 2019 - National Medical Research Council NMRC STaR award in Singapore
  • 2014/08 - 第43階国際実験血液学会(ISEH) Donald Metcalf Award
  • 2014 - National Medical Research Council NMRC STaR award in Singapore
  • 2013/02 - The Seoul Archdiocesan Committee for Life The 7th Mystery of Life Award
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