Imaizumi Tadaatsu

イマイズミタダアツ | Imaizumi Tadaatsu

Homepage URL (1)： https://timaizum.wixsite.com/vbversion2

Research field (1)： Cell biology

Research keywords (4)：炎症 , 血管内皮細胞 , Inflammation , Vascular Endothelial Cells

Research theme for competitive and other funds (23)：

2022 - 2025 Inflammatory pathways via innate immunity in resident renal cells and their regulation against the development of kidney injury
2021 - 2024 The role and mechanism of VEGFR2 on aortic valve calcification
2019 - 2024 小児特発性ネフローゼ症候群におけるSMPDL-3bの意義の解明
2020 - 2023 プレグナンX受容体を介する大動脈弁異所性石灰化機序の解明と病態生理学的意義の実証
2019 - 2022 Demonstration and mechanism elucidation of the inhibition of aortic valve calcification by controlling expression of extracellular matrix protein

2017 - 2020 Molecular mechanisms of chronic renal diseases by Interferon-stimulated genes (ISGs)

2016 - 2019 Glomerular inflammation induced by innate immune reaction in residual glomerular cells and future therapeutic strategy for CKD

2014 - 2017 Study on local regulation of gene expression of female reproductive-specific IFN

2013 - 2016 Mesangial viral and psuedoviral immunity: possible involvement in the pathogenesis of glomerulonephritis

2013 - 2016 Role of mesangial RNA recognition receptors in innate immunity and chronic renal diseases

2013 - 2015 The regulatory mechanisms of the CD80 expression in the podocytes.

2011 - 2013 Elucidation of interorganelle network in RLRs-mediated innate immunity

2010 - 2012 Implication of the expression of retinoic acid-inducible gene-I in human glomerulonephritis

2009 - 2012 Development of therapeutic strategies for RA targeting TNF-α-inducible RNA receptors in cytoplasm

2008 - 2010 Study on regulation of gene expression of a novel female reproductive organ-specific Type I interferon

2008 - 2010 Identification of NUB1-interacting proteins in alpha-synucleinopathy

2005 - 2008 Role of a new Toll-like receptor-related signaling molecule in immunereactions in lung and airway

2002 - 2004 脳血管障害におけるオピオイドペプチドの新しい働き:ヘモルフィンの関与

2002 - 2004 Molecular pathomechanisms in alpha-synucleinopathis

2001 - 2002 パーキンソン病におけるα-シヌクレイン蓄積機序に関する研究

1999 - 2000 Smoking-induced generation of oxidized phospholipids and the effect of deficiency of hydrolyzing enzyme for oxidatively modified phospholipids : role of the enzyme deficiency in carcinogenesis and vascular injury.

血管内皮細胞

Vascular Endothelial Cells

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Papers (181)：

Yuri Kobori, Mayuki Tachizaki, Tadaatsu Imaizumi, Yusuke Tanaka, Kazuhiko Seya, Yasuo Miki, Shogo Kawaguchi, Tomoh Matsumiya, Yuki Tobisawa, Chikara Ohyama, et al. TMEM2 suppresses TLR3-mediated IFN-β/ISG56/CXCL10 expression in BEAS-2B bronchial epithelial cells. Molecular biology reports. 2024. 51. 1. 417-417
Yuzuru Nakamura, Hikaru Kristi Ishibashi, Tatsuro Saruga, Tadaatsu Imaizumi, Akira Kurose, Mayuki Tachizaki, Shogo Kawaguchi, Kazuhiko Seya, Eiji Sasaki, Yasuyuki Ishibashi. Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling. Molecular biology reports. 2024. 51. 1. 131-131
Takao Karasawa, Riko Sato, Tadaatsu Imaizumi, Masashi Fujita, Tomomi Aizawa, Koji Tsugawa, Deborah Mattinzoli, Shogo Kawaguchi, Kazuhiko Seya, Kiminori Terui, et al. Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis. Renal failure. 2023. 45. 1. 2224890-2224890
Shogo Kawaguchi, Hirotake Sakuraba, Hidezumi Kikuchi, Kota Matsuki, Yudai Hayashi, Jiangli Ding, Yusuke Tanaka, Kazuhiko Seya, Tomoh Matsumiya, Hiroto Hiraga, et al. Polygonum tinctorium leaf extract ameliorates high-fat diet-induced intestinal epithelial damage in mice. Experimental and therapeutic medicine. 2023. 25. 3. 112-112
Tomoh Matsumiya, Yuko Shiba, Jiangli Ding, Shogo Kawaguchi, Kazuhiko Seya, Tadaatsu Imaizumi. The double-stranded RNA-dependent protein kinase PKR negatively regulates the protein expression of IFN-β induced by RIG-I signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 2. e22780

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MISC (122)：

津川浩二, 佐藤理子, 橋本峻, 藤田真司, 相澤知美, 照井君典, 田中完, 城謙輔, 今泉忠淳. ヒト培養糸球体内皮細胞における抗ウイルスエフェクター蛋白interferon-stimulated gene 20発現と腎炎症候群の病態形成への関与. 日本小児腎臓病学会雑誌. 2023. 36. Suppl. 95-95
木村俊郎, 今泉忠淳, 吉田秀見, 松宮朋穂, 瀬谷和彦, 川口章吾, 早狩亮, 島田拓, 吉田達哉, 小林完, et al. 胆道閉鎖症におけるウイルス感染の関与に関する分子生物学的検討. 弘前医学. 2019. 69. 1-4. 201-201
木村紗也佳, 松宮朋穂, 吉田秀見, 瀬谷和彦, 川口章吾, 今泉忠淳. 一本鎖RNAウイルスのゲノムRNA分解機構解明へ向けた基礎検討. 弘前医学. 2019. 69. 1-4. 207-207
今泉忠淳, 松宮朋穂, 吉田秀見. 培養ヒト脳微小血管内皮細胞におけるinterferon-stimulated gene 60(ISG60)の発現に対するToll様受容体3アゴニストの影響. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [2P-341]
田中完, 相澤知美, 渡邊祥二郎, 津川浩二, 敦賀和志, 城謙輔, 今泉忠淳. ヒト培養糸球体内皮細胞におけるToll-like receptor 3を起点とする好中球遊走・接着因子の発現. 日本小児腎臓病学会雑誌. 2018. 31. 1Suppl. 150-150

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Education (3)：

Hirosaki University School of Medicine
Hirosaki University Graduate School of Medicine
Hirosaki University School of Medicine

Professional career (1)：

M.D.

Work history (6)：

2013 - Hirosaki University
2007 - 弘前大学助教
1997 - Hirosaki University
1997 - Assistant Professor, Hirosaki University
1991 - ユタ大学研究員

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Association Membership(s) (5)：

日本血管生物医学会 , 日本内科学会 , 日本生化学会 , The Japanese Society of Internal Medicine , The Japanese Biochemical Society

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