2017 - 2020 Exploration of molecular mechanism of synergistic effects induced by ER/ERR co-expression which enhances signal toxicity by novel bisphenol derivatives
2017 - 2019 Development of low environmental load type-ion adsorption peptides
2015 - 2019 Elucidation of enhancement mechanism of the nuclear receptor binding property of bisphenol A caused by chemical modification
2014 - 2016 Development of the metal ion recovery material using the self-aggregating peptides as base materials
2010 - 2015 Signal toxicity mediated through nuclear receptors of new generation bisphenols
2001 - 2012 環境ホルモンのリスク調査
1993 - 2012 受容体活性化機構に関する研究
2007 - 2009 Elucidation of bisphenol A low-dose effects mediated through the nuclear receptor ERRγ
1993 - 2008 Study on receptor activation mechanism
2005 - 2007 クロロベンゼン環およびブロモベンゼン環が誘起する強力な受容体結合力の解明
2004 - 2006 Risk assessment of endocrine disruptors in nuclear receptors by means of antibody-sensing method to measure the conformation change associated with ligand binding
2001 - 2006 Study on endocrine disruptors
1994 - 2005 セリンプロテアーゼインヒビターに関する研究
1994 - 2005 Study on snake venom enzymes
1994 - 2005 Study on dipeptidyl serinprotease inhibitor
1998 - 1999 Novel Bioactive Conformation Constructed by Structurally Constrained CH/π Interaction between Amino Acids Side Chains
1997 - 1999 Joint Study on Molecular Mechanism of Opioid Receptors
1996 - 1997 Studies on the molecular mechanism of thrombin receptor activation by means of ligand peptides containing a series of fluorinated phenylalanines
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Papers (145)：
Keitaro Suyama, Masayuki Murashima, Iori Maeda, Takeru Nose. Enhancement of Aggregate Formation Through Aromatic Compound Adsorption in Elastin-like Peptide (FPGVG)5 Analogs. Biomacromolecules. 2023. 24. 11. 5265-5276
Kohei Yoshida, Keitaro Suyama, Shin Matsushita, Iori Maeda, Takeru Nose. Development of the efficient preparation method for thermoresponsive elastin-like peptides using liquid-phase synthesis combined with fragment condensation strategy. Journal of Peptide Science. 2023. e3528
Keisuke Tomohara, Juthamart Maneenet, Nao Ohashi, Takeru Nose, Rintaro Fujii, Min Jo Kim, Sijia Sun, Suresh Awale. Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach. Biological & pharmaceutical bulletin. 2023. 46. 10. 1412-1420
Daiki Tatsubo, Keitaro Suyama, Naoki Sakamoto, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose. Determining the Sequence Dependency of Self-Assembly of Elastin-Like Peptides Using Short Peptide Analogues with Shuffled Repetitive Sequences. Biochemistry. 2023
Keitaro Suyama, Hitoshi Kesamaru, Takashi Okubo, Kazumi Kasatani, Keisuke Tomohara, Ayami Matsushima, Takeru Nose. High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways. Heliyon. 2023. 9. 1. e13003
SEVILLA Anton Luis. Change of Student's Awareness During the KIKAN Education Seminar : Focus on the Improved Program Under the Quarter System and the Significance of the Seminar. 2019. 5. 57-74
