Rchr
J-GLOBAL ID:200901041528853214
Update date: Apr. 05, 2024
Ohtsu Naoki
オオツ ナオキ | Ohtsu Naoki
Affiliation and department:
Job title:
Researcher (Concurrent post)
Research field (4):
Medical biochemistry
, Developmental biology
, Cell biology
, Molecular biology
Research keywords (7):
Genome editting
, induced cancer stem cell
, Eva1
, Hematopoietic Stem Cell
, glioma-initiating cell, GIC
, Glioblastoma multiforme, GBM
, Hematopoiesis
Research theme for competitive and other funds (9):
- 2018 - 2021 Establishment of Eva1 positive Glioma Stem Cell Suppression system using Genome Editing
- 2016 - 2018 Chemical Screening of RelB-NF-kB Signal Inhibitor in Glioblastoma-Initiating Cells
- 2011 - 2012 Functional analysis of HIPK family genes in hematopoiesis derived from hemogenic endothelial cells and mesodermal cells
- 2011 - 2012 Functional analysis of HIPK2 in the differentiation of vascular endothelial progenitor cell into hematopoietic stem cells
- 2011 - 2012 Effect of nsPEF and IBSEFin hematopoietic cell differentiation
- 2010 - 2011 Functional analysis HIPK family genes in the proliferation and differentiation of hematopoietic progenitor cells
- 2010 - 2011 Functional analysis of HIPK2 in the differentiation of vascular endothelial progenitor cell into hematopoietic stem cells
- 2006 - 2007 Elucidation of HIPK2-activating cell in construction of embryo hematopoiesis of mouse
- 2004 - 2005 Search for genes that expression is regulated by HIPK2 in AGM hematopoiesis
Show all
Papers (10):
-
Naoki Ohtsu, Shota Katayama. A more efficient method for generating glioblastoma-multiforme model in mice using genome editing technology. Biochemical and Biophysical Research Communications. 2024. 149657-149657
-
Naoki Ohtsu. Induction of tumor-initiating cells and glioma-initiating cells from fetal neural stem cells through p53 genome editing. bioRxiv. 2022
-
Yoshihiro Tsukamoto, Naoki Ohtsu, Smile Echizenya, Satoko Otsuguro, Ryosuke Ogura, Manabu Natsumeda, Mizuho Isogawa, Hiroshi Aoki, Satoshi Ichikawa, Masahiro Sakaitani, et al. Chemical Screening Identifies EUrd as a Novel Inhibitor Against Temozolomide-Resistant Glioblastoma-Initiating Cells. STEM CELLS. 2016. 34. 8. 2016-2025
-
Shota Katayama, Tetsuo Moriguchi, Naoki Ohtsu, Toru Kondo. A Powerful CRISPR/Cas9-Based Method for Targeted Transcriptional Activation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2016. 55. 22. 6452-6456
-
Naoki Ohtsu, Yuka Nakatani, Daisuke Yamashita, Shiro Ohue, Takanori Ohnishi, Toru Kondo. Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-kappa B Signaling Pathway. CANCER RESEARCH. 2016. 76. 1. 171-181
more...
MISC (8):
-
大津 直樹, 中谷 有香, 山下 大介, 大西 丘倫, 近藤 亨. Glimはマウス及びヒトのグリオーマ形成能を亢進させる. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4T18-12(3P1074)]
-
大津直樹, 中谷友香, 山下大介, 大西丘倫, 近藤亨. 新規グリオーマ幹細胞膜タンパク質Glimの機能解析. 日本分子生物学会年会プログラム・要旨集(Web). 2013. 36th. 1P-0815 (WEB ONLY)
-
Toshihiro Inoue, Tetsushi Kagawa, Miyuki Inoue-Mochita, Kyoichi Isono, Naoki Ohtsu, Ikuo Nobuhisa, Mikiko Fukushima, Hidenobu Tanihara, Tetsuya Taga. Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS LETTERS. 2010. 584. 14. 3233-3238
-
Toshihiro Inoue, Tetsushi Kagawa, Miyuki Inoue-Mochita, Kyoichi Isono, Naoki Ohtsu, Ikuo Nobuhisa, Mikiko Fukushima, Hidenobu Tanihara, Tetsuya Taga. Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS LETTERS. 2010. 584. 14. 3233-3238
-
井上 俊洋, 藤本 智和, 井上 みゆき, 大津 直樹, 亀田 隆範, 笠岡 奈々子, 木許 賢一, 谷原 秀信. 線維柱帯細胞のTGF-β2誘発コラーゲンタイプ1発現上昇におけるRho/ROCK経路の関与. 日本眼科学会雑誌. 2010. 114. 臨増. 332-332
more...
Lectures and oral presentations (8):
-
Cross-species transmission of;rat hepacivirus;its adaptation to mouse
(The Japanese Society for Virology 2021)
-
Eva1 maintains the characteristics of glioblastoma-initiating cells through the activation of non-canonical NF-kB signaling pathway
(Keystone Symposia , Stem Cells and Cancer 2016)
-
Eva1 enhance the formation and development of gliomas in mouse and human
(BMB2015 Biochemistry and Molecular Biology 2015)
-
Inhibitory Effects of Homeodomain-Interacting Protein Kinase 2 on the Aorta-Gonad-Mesonephros Hematopoiesis
(The 20th IUBMB International Congress of Biochemistry and Molecular Biology and the 11th FAOBMB Congress 2006)
-
HIPK2 による胎生期造血発生抑制機構の解析
(第35回日本免疫学会年会 2005)
more...
Education (3):
- 2003 - 2007 Kumamoto University Graduate school of medical science
- 2001 - 2003 Kumamoto University Graduate School of Science and Technology Department of Systems in Natural Environment
- 1997 - 2001 Kumamoto University Faculty of Science Department of biological science
Professional career (1):
- Ph.D. (Kumamoto University)
Work history (7):
- 2024/04 - 現在 University of Tsukuba Laboratory for Stem Cell Therapy Research (Concurrent post)
- 2023/04 - 現在 Celaid Theraputics Inc. Research and Development Division Chief Researcher
- 2021/04 - 2023/03 University of Yamanashi Graduate School of Medicine Project Research Associate
- 2015/04 - 2021/03 Institute for Genetic Medicine, Hokkaido University Division of Stem Cell Biology Assistant Proffesor
- 2012/04 - 2015/03 Institute fot Genetic Medicine, Hokkaido University Division of Stem Cell Biology Postdoctoral Fellow
- 2012/01 - 2012/03 Ehime Proteo-Medicine Research Center Department of Stem Cell Biology Postdoctral fellow
- 2010/04 - 2011/12 Institute of Medical embryology and Genetics, Kumamoto University Division of Cell Differentiation GCOE Research Associate
Show all
Awards (2):
- 2017/07 - Institute of Medicine, Hokkaido University Azuma Ichito Fund
- 2017/07 - 2nd International conference on Tumor & Cancer Immunology and Immunotherapy Best Poster Award Inhibition of Eva1 degrade the formation and development of glioblastomas
Association Membership(s) (2):
Japanese cancer associate
, The Molecular Biology Society of Japan
Return to Previous Page