Mukudai Yoshiki

ムクダイヨシキ | Mukudai Yoshiki

Affiliation and department：

Research field (5)： Surgical dentistry , Cell biology , Molecular biology , Oral medicine , Tumor biology

Research keywords (13)： stress granule , Post-transcriptional regulation , P-body , TPD52 family proteins , Oral cancer , Cartilage metabolism , Bone metabolism , RNA cis-element , RNA binding proteins , 転写因子 , mRNA stability , Transcription Factor , mRNA

Research theme for competitive and other funds (28)：

2022 - 2026 Roles of suprabasin on OSCC cells as a hypoxia-resistant factor
2022 - 2025 神経障害性疼痛の病態におけるTRPV1 Self-activation仮説の立証
2020 - 2023 メタゲノム解析を応用した心臓弁膜症の病態の解明と有効な周術期口腔機能管理法の確立
2017 - 2023 Involvement of resident oral microorganisms in the pathophysiology and degree of progression of valvular heart disease
2018 - 2022 Role of TPD52 as a suvival factor on OSCC cells in a hypoxic condition

2018 - 2022 Development of new drug therapy for inferior alveolar nerve neuropathy based on autophagy.

2018 - 2021 Molecular mechanism of oral cancer induced by human papillomavirus

2017 - 2021 Effects of autophagy caused by osteoarthritis

2015 - 2019 Analysis of telomerase-specific replication-selective oncolytic viruses for oral squamous cell carcinoma stem cells

2015 - 2018 Identification of novel intra-cellular proteins binding to TPD54 protein

2014 - 2017 The study of jaw bone regeneration therapy with the complex of PRF, SHAp, and ASCs

2014 - 2016 A combination of low-intensity pulsed ultrasound and nanohydroxyapatite concordantly enhances osteogenesis of adipose-derived stem cells from buccal fat pad

2012 - 2015 Identification of Sjogren's syndrome-associated antigens using heterozygous mutant mice systematically lacking of the PTEN

2012 - 2015 Establishment of the oral cancer metastasis prediction marker with expression of miRNA analysis

2012 - 2015 Involvement of the Warburg effect in the regulation of ccn2 gene expression

2011 - 2013 Detection of carcinoma cells in peripheral circulation by oncolgtic virus therapy

2011 - 2013 The post-transcriptional regulatory system of gene expressionof in chondrocytes by ncleophosmin

2011 - 2013 The regenerative therapy of the jaw by auto-transplantation of adipose-derived stem cells

2005 - 2006 Role of CCN2 as a trans-modulator in the integrated development of bone, cartilage and hematopoietic systems

2003 - 2006 The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering

2004 - 2005 RNA干渉を用いたCCN遺伝子ファミリーの包括的機能解析とその応用

2002 - 2003 Functional dissection and medical application of the 4 modules in the chondrocyte-derived growth factor, ecogenin/CTGF.

2003 - Analysis of post-transcriptional regulation of ctgf gene

2002 - Analysis of cis-element of CEF-10mRNA

2000 - 2001 Development of analytical method for each domain of CTGF/ecogenin and its clinical application.

Cloning of CTGF/Hcs 24 Receptor

Effects of calcitone on growth and metastasis of breast cancer cells

Effects of chondrocyte-derivied chrondrocyte growth factor Hcs24/CTGF in chondrocytes

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Papers (78)：

Asami Houri, Yoshiki Mukudai, Yuzo Abe, Masataka Watanabe, Maki Nara, Saya Miyamoto, Mai Kurihara, Toshikazu Shimane, Tatsuo Shirota. Suprabasin enhances the invasion, migration, and angiogenic ability of oral squamous cell carcinoma cells under hypoxic conditions. Oncology Reports. 2023. 49. 5
YASO Atsutoshi, KAMATANI Takaaki, MUKUDAI Yoshiki, ABE Yuzo, SHIROTA Tatsuo. Tumor protein D54: A promising marker of mucoepidermoid carcinoma. Showa Univ J Med Sci. 2022. 34. 1. 1-10
Atsutoshi Yaso, Takaaki Kamatani, Yoshiki Mukudai, Yuzo Abe, Tatsuo Shirota. Tumor protein D54: A promising marker of mucoepidermoid carcinoma. The Showa University Journal of Medical Sciences. 2022. 34. 1. 1-10
Shinsuke Nakamura, Yoshiki Mukudai, Junichiro Chikuda, Meilin Zhang, Hideyuki Shigemori, Kazunaga Yazawa, Seiji Kondo, Toshikazu Shimane, Tatsuo Shirota. Combinational Anti-tumor Effects of Chemicals from Paeonia lutea Leaf Extract in Oral Squamous Cell Carcinoma Cells. Anticancer research. 2021. 41. 12. 6077-6086
Mai Kurihara, Yoshiki Mukudai, Hitoshi Watanabe, Mariko Asakura, Yuzo Abe, Asami Houri, Junichiro Chikuda, Toshikazu Shimane, Tatsuo Shirota. Autophagy prevents osteocyte cell death under hypoxic conditions. Cells, tissues, organs. 2021

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MISC (19)：

Yoshiki Mukudai, Kosuke Kato, Hiromi Motohashi, Chihiro Ito, Shinnosuke Kamoshida, Toshikazu Shimane, Seiji Kondo, Tatsuo Shirota. Opposite effects of TPD52 and TPD54 on oral squamous cell carcinoma cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2017. 40. S8-S8
江口傑徳, 江口傑徳, 久保田聡, 河田かずみ, 椋代義樹, 上原淳二, 大河原敏博, 大河原敏博, 伊原木聰一郎, 佐々木朗, et al. 軟骨細胞においてMMP3は核移行しCCN2/CTGFの転写活性化因子として働く. 日本軟骨代謝学会プログラム・抄録集. 2009. 22nd
T. Eguchi, S. Kubota, K. Kawata, Y. Mukudai, T. Yanagita, T. Ohgawara, J. Uehara, S. Ibaragi, M. Takigawa. Novel transcription factor-like function of MMP-3/stromelysin-1 that regulates connective tissue growth factor (CTGF/CCN2) gene transcription. JOURNAL OF BONE AND MINERAL RESEARCH. 2007. 22. S261-S261
江口傑徳, 久保田聡, 河田かずみ, 椋代義樹, 大河原敏博, 上原淳二, 伊原木聰一郎, 佐々木朗, 窪木拓男, 滝川正春, et al. 軟骨細胞においてマトリックス金属プロテアーゼ-3(MMP3)は核移行し結合組織成長因子(CCN2/CTGF)の転写活性化因子として働く. 生化学. 2007
A. McAlinden, L. Liang, Y. Mukudai, T. Imamura, L. Sandell. Nuclear protein TIA-1 regulates alternative splicing of COL2A1. MATRIX BIOLOGY. 2006. 25. S70-S70

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Lectures and oral presentations (28)：

Suprabasin(SBSN) enhances cell infiltration and vascular inductionattraction under hypoxia in OSCC cells.
(46th Annual Meeting of the Molecular Biology Society of Japan 2023)
Suprabasin (SBSN) enhances cell immigration and vascular induction in OSCC cells under hypoxia.
(The 67th Congress of the Japanese Society of Oral and Maxillofacial Surgery 2022)
Expression of the TPD52 gene is post-transcriptionally regulated via mRNA stability by TIA-1 and TIAR.
(The 40th Annual meeting of JAPAN HUMAN CELL SOCIETY 2022)
Tumor protein D52 is upregulated in oral squamous carcinoma cells under hypoxia in a hypoxia inducible factor independent manner and is involved in cell death resistance
(The 40th Annual meeting of JAPAN HUMAN CELL SOCIETY 2022)
Tumor protein D52 is upregulated in oral squamous carcinoma cells under hypoxia in a hypoxia-inducible-factor-independent manner and is involved in cell death resistance
(2021)

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Education (2)：

1995 - 1999 Osaka University Graduate School Faculty of Dentistry Biochemistry
1989 - 1995 Hiroshima University School of Dentistry

Work history (7)：

2023/08 - 現在 Showa University School of Dentistry
2011/04 - 2023/08 Showa University School of Dentistry Assistant Professor
2010/03 - 2011/03 Showa University School of Dentistry Post-doctoral Fellow
2008/09 - 2009/07 Keio University School of Medicine Post-doctoral Fellow
2008/05 - 2008/08 Cleveland Clinic Lerner Research Institute Post-doctoral Fellow

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Awards (2)：

2012/04 - The Nakatomi Foudation The Nakatomi Foudation grant
2005/09 - Japanese Association for Oral Biology JAOB Award Regulation of chicken ccn2 gene by interaction between RNA cis -element nad putative trans -factor during differentiation of chondrocytes

Association Membership(s) (6)：

日本口腔組織培養学会 , JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPANESE SOCIETY FOR ORAL BIOLOGY , 日本軟骨代謝学会 , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH

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