Rchr
J-GLOBAL ID：200901041704207618
Update date: Jan. 31, 2024
Iwai Shigenori
イワイ シゲノリ | Iwai Shigenori
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.chem.es.osaka-u.ac.jp/bio/
Research field (3)：
Molecular biology
, Synthetic organic chemistry
, Molecular biochemistry
Research theme for competitive and other funds (25)：
- 2020 - 2023 Fluorescence detection of cellular ability of mismatch repair using synthetic DNA
- 2016 - 2021 Higher-order regulatory mechanisms for DNA damage recognition in nucleotide excision repair
- 2014 - 2016 Mechanisms and functions of i-RNase activity
- 2013 - 2016 Alternative DNA repair pathways of DNA damage induced by topoisomerase inhibitor
- 2011 - 2016 Cross-regulation of the maintenance and mutagenesis of genomic sequence and epigenetic information
- 2012 - 2015 Single-molecule direct visualization of DNA repair proteins on chromatin
- 2012 - 2015 Detection of structural change of DNA using disulfide bond formation and its application to elucidation of molecular recognition mechanisms
- 2012 - 2015 Novel molecular mechanism maintaining genomic homeostasis against environmental stresses
- 2010 - 2012 Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase
- 2009 - 2011 Detection and analysis of DNA repair using chemically-synthesized DNA sensors
- 2005 - 2009 Molecular mechanisms of translesion DNA synthesis and its involvement in carcinogenesis
- 2005 - 2007 Recognition of UV-clamaged DNA by antinoglycoside antibiotics
- 2003 - 2004 Search for low-molecular-weight compounds that specifically bind UV-damaged DNA
- 2000 - 2003 Development of functional analysis of genes in cells using functional nucleic acids
- 1994 - 1994 核磁気共鳴によりリボヌクレアーゼHの基質認識機構の解析
- 1994 - 1994 修飾オリゴヌクレオチドを用いた紫外線損傷DNA修復機構の解析
- 1993 - 1994 Photodamage repair of DNA by anti thymine dimer antibody
- 1993 - 1993 紫外線損傷塩基を含む化学合成オリゴヌクレオチドと修復酵素との相互作用の解析
- 1993 - 1993 紫外線誘発DNA損傷による発癌遺伝子活性化に関する研究-化学合成オリゴヌクレオチドを用いた部位特異的導入法によるアプローチ
- 1990 - 1990 T4エンドヌクレア-ゼVの基質認識機構の解析
- 1990 - 1990 チミンダイマ-除去修復機構の合成遺伝子による解析
- 1989 - 1990 Elucidation of the Mechanism for the Self-Cleavage Rection of RNA Using Chemically-Synthesized Oligonucleotides
- 1987 - 1988 Development of site-specific RNA cleaving method using modified DNA splints-RNase H system
- 1986 - 1986 合成遺伝子を用いるDNA修復酵素の機能の研究
- 1985 - 1986 Development of cancer diagnosis using monoclonal antibodies specific for ras gene products
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Papers (238)：
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Naoto Shimizu, Yusaku Hamada, Ryosuke Morozumi, Junpei Yamamoto, Shigenori Iwai, Kei-ichi Sugiyama, Hiroshi Ide, Masataka Tsuda. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding. Journal of Biological Chemistry. 2023. 104988-104988
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Jun-ichi Akagi, Masayuki Yokoi, Yumi Miyake, Tsuyoshi Shirai, Tomohiro Baba, Young-Man Cho, Fumio Hanaoka, Kaoru Sugasawa, Shigenori Iwai, Kumiko Ogawa. A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis. Journal of Biological Chemistry. 2023. 105002-105002
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Yohei Sugimoto, Yuji Masuda, Shigenori Iwai, Yumi Miyake, Rie Kanao, Chikahide Masutani. Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans. Nucleic Acids Research. 2023. 51. 10. 4959-4981
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Arato Takedachi, Erina Matsuishi, Shouji Mizusaki, Tomoki Nagasawa, Ryosuke Fujikane, Masumi Hidaka, Shigenori Iwai, Isao Kuraoka. Novel plasmids for the fluorescence-based evaluation of DNA mismatch repair in human cells. Mutation Research. 2022. 824. 111779-111779
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Yuhei Hosokawa, Pavel Müller, Hirotaka Kitoh-Nishioka, Shigenori Iwai, Junpei Yamamoto. Limited solvation of an electron donating tryptophan stabilizes a photoinduced charge-separated state in plant (6-4) photolyase. Scientific Reports. 2022. 12. 5084
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MISC (33)：
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Kei Kunimasa, Yuya Bando, Miyako Shiraishi, Emi Aizawa, Kazumi Nishino, Motohiro Tamiya, Takoko Inoue, Hanako Kuhara, Hayato Kawachi, Kika Kuno, et al. Development CRISPR-Cas12-based rapid EGFR mutation detection kit. JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 15
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Masayuki Kusakabe, Yuki Onishi, Haruto Tada, Fumika Kurihara, Kanako Kusao, Mari Furukawa, Shigenori Iwai, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa. Mechanism and regulation of DNA damage recognition in nucleotide excision repair. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2019. 41. 2-2
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D. Yamada, H. M. Dokainish, T. Iwata, J. Yamamoto, T. Ishikawa, T. Todo, S. Iwai, E. D. Getzoff, K. Yura, A. Kitao, et al. Function conversion between CPD and (6-4) photolyases. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S82-S82
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D. Yamada, H. M. Dokainish, T. Iwata, J. Yamamoto, T. Ishikawa, T. Todo, S. Iwai, E. D. Getzoff, K. Yura, A. Kitao, et al. Function conversion between CPD and (6-4) photolyases. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S276-S276
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D. Yamada, T. Iwata, J. Yamamoto, T. Ishikawa, E. D. Getzoff, T. Todo, S. Iwai, H. Kandori. Asymmetrical functional conversion of (6-4) photolyase and CPD photolyase. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2015. 44. S66-S66
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Education (2)：
- 1982 - 1984 Osaka University
- 1978 - 1982 Osaka University School of Pharmaceutical Sciences
Work history (4)：
- 2001 - 2003 東京大学大学院助教授
- 1995 - 2001 生物分子工学研究所主任研究員
- 1988 - 1995 Hokkaido University
- 1984 - 1988 Hokkaido University
Association Membership(s) (3)：
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