Rchr
J-GLOBAL ID：200901041886054250
Update date: Apr. 21, 2024
Yamaguchi Akira
ヤマグチ アキラ | Yamaguchi Akira
Affiliation and department：
Job title：
Others
Research field (3)：
Oral medicine (pathology)
, Oral medicine
, Experimental pathology
Research keywords (3)：
Bone cell biology
, Oral Pathology
, Pathology
Research theme for competitive and other funds (74)：
- 2022 - 2025 Differentiation mechanism of cell groups appearing in the healing process of pulp revascularization procedure.
- 2020 - 2023 GABA受容体rho2の破骨細胞分化調節機構の解明とそのアゴニストの臨床応用
- 2020 - 2023 FGF23産生機序とリン代謝異常を基軸とする顎骨線維性骨異形成症の包括的病態理解
- 2019 - 2022 Establishment of Platform for Dentin Regeneration Drug Discovery by Targeting Multiple Signals that Regulate Odontoblast Function and Differentiation
- 2017 - 2020 Establishment and application of disease-specific iPS cells for Apert syndrome
- 2017 - 2020 Multiscale analysis of peri-implant bone based on mechanobiology
- 2016 - 2020 Development and application of the trace elements and micro structure analyses of tissue specimens using the quantum beams
- 2016 - 2018 Establishment of iPS cells from McCune-Albright syndrome and it application
- 2014 - 2017 The analysis of the role of CCN3 in the formation of vascularization at the tissue regeneration and the constraction of the drug discovery
- 2014 - 2016 Evolutional investigation of the hematopoietic niches in bone marrow
- 2013 - 2016 Comprehensive analyses of the mechanism of bone destruction by oral cancer
- 2011 - 2014 Visualization of oral cancer microenvironment using molecular imaging and its application to radiotherapy
- 2011 - 2013 Serum calcium upregulates Fgf23 expression by Dickopf-1-mediated inhibition of Wnt/beta-catenin signaling in bone
- 2011 - 2012 Investigation for the bone clock development by bioluminescence and fluorescence imaging on brain and bone
- 2011 - 2012 Challenge to clarify the acquirement of osteonetwork
- 2010 - 2012 Strategic Survey of Trends Toward Oral Pathology Standardization and Oral Pathology Board Certification in Asia for the New Century
- 2010 - 2012 Maintenance and disturbance of osteonetwork: basic studies on clarification of pathophysiology of craniofacial bone diseases
- 2009 - 2011 Pathophysiological significance of altered kerakin expression in oral cancer
- 2009 - 2010 骨再生過程におけるOsteocrine factorの同定
- 2007 - 2009 Crosstalk among cells and molecules during bone regeneration
- 2006 - 2007 Analysis of regulation of osteogenesis by Notch signaling andits application to boneregeneration therapy
- 2006 - 2007 Regeneration of resorbed tooth roots by cementogenesis
- 2005 - 2006 脊椎動物の進化における骨格形成の変遷を解析するための基盤研究
- 2002 - 2006 Comprehensive analysis of bone formation and its application
- 2004 - 2005 二本鎖RNAを導入したC.elegansの渦巻き反射と重力ストレス-痛み受容相関
- 2003 - 2004 gene therapy for massive bone defects : Development of the delivery system for clinical use
- 2002 - 2004 Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development : comparison of MR imaging and histological findings
- 2002 - 2004 Comprehensive approach to identify novel molecules involved in osteogenesis and chondrogenesis during tooth development.
- 2000 - 2004 骨芽細胞の分化調節機構を基盤として新しい骨再生療法を開発する
- 2002 - 2003 歯周組織幹細胞(Periodontal Stem Cell)は存在するか?
- 2002 - 2003 ヒト過誤腫から多分化能を保持した細胞株を樹立し、骨軟骨分化機構解析に利用する試み
- 2002 - 2003 Functional analysis of TNF signaling in bone metabolism using knocked-out mice of type I and II TNF receptors.
- 2001 - 2002 Microscopic analysis of three-dimensional trabecular structure using X-ray and syncrotron radiation
- 2000 - 2002 炎症性サイトカイン関連遺伝子変異マウスを用いて歯周組織破壊と再生の機序を解析する
- 2000 - 2001 カエルのオタマジャクシと成体の骨格の解析により骨粗鬆症の病態像を再考する試み
- 2000 - 2001 Exhaustive analysis of gene expression dining bone regeneration
- 2000 - 2001 DEVELOPMENT OF A NEW THERAPEUTC APPROCH TO BONE REGENERATION FOR GENE THERAPY
- 1999 - 1999 骨格系の制御プログラムと疾患
- 1999 - 1999 骨芽細胞の分化調節機構の細胞生物学的・分子生物学的解析
- 1998 - 1999 cbfa1ヘテロ接合体マウスはヒト鎖骨頭蓋異形成症のモデルとなるか?
- 1998 - 1999 Recovery of bone forming ability with bone morphogenetic protein from radiation injury
- 1998 - 1999 The roles of nuclear transcription factors in calcium homeostasis
- 1997 - 1999 Application of Hedgehog Proteins as Drugs for Induction of Hard Tissues and Repair of Hard Tissue Defects.
- 1997 - 1999 Studies on Clarification of Pathological Conditions of Osteoporosis in the Ora
- 1998 - 1998 骨形成機構の細胞生物学・分子生物学的解析
- 1997 - 1998 Role of hedgehogs in differentiation of cultured osteoblasts
- 1997 - 1998 Development of a therapeutic method of bone repair using BMP responding mesencbymal cells
- 1997 - 1998 Morphological and molecular analyses of bone repair
- 1997 - 1997 骨形成機構の細胞生物学的・分子生物学的解析
- 1995 - 1997 Establishment of assay systems for examining bone metabolism : Studies on differentiation and function of osteoblasts and osteoclasts
- 1996 - 1996 骨芽細胞の放射線感受性に及ぼす多因子の相関
- 1995 - 1996 Role of BMP in fracture repair
- 1994 - 1996 Role of BMPs in differentiation process of osteoblasts, chondrocytes and muscle cells
- 1995 - 1995 オステオポンチン遺伝子導入トランスジェニックマウスの解析
- 1993 - 1995 Development of reliable screening systems for drugs which regulate bone resorption : In vitro assay systems for osteoclast formation and function.
- 1994 - 1994 骨組織薄切切片を用いた器官培養系の確立
- 1993 - 1994 Study for differentiation process of osteoblasts
- 1993 - 1993 成熟骨組織中で骨芽細胞の新生を促す因子に対する受容体遺伝子を、形態学的に探し出す
- 1992 - 1993 Investigation of mechanism of bone formation associated with aging
- 1991 - 1993 Development and its application of simple methods for bone sections
- 1989 - 1991 Establishment of the screening methods for bone-resorbing factors using in vitro osteoclast formation system.
- 1990 - 1990 破骨細胞の分化段階および活性状態の組織化学的方法による解明
- 1989 - 1990 Establishment of Assay System for Studying Osteoblastic Function and Differentiation Using Newly Isolated Osteoblast-Like Cell Lines
- 1989 - 1990 Molecular Biological and Immunohistochemical Study of Differentiation of the Osteoblast.
- 1988 - 1989 Role of the osteoclast and osteoblast during the bone resorption
- 1988 - 1989 Production and characterization of monoclonal antibodies that react with osteoblasts
- 脊椎動物の進化における骨格形成の変遷
- 癌による骨破壊のメカニズム
- 口腔疾患の臨床病理学的研究
- 骨形成・骨再生の分子メカニズム
- Development of new therapy for bone regeneration
- Development of new drugs for osteoporosis
- Bove cell Biology
- Oral Pathology
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Papers (299)：
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Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, et al. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. International journal of oral science. 2024. 16. 1. 18-18
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Hiroyuki Ogura, Takashi Nakamura, Takenobu Ishii, Akiko Saito, Shoko Onodera, Akira Yamaguchi, Yasushi Nishii, Toshifumi Azuma. Mechanical stress-induced FGF-2 promotes proliferation and consequently induces osteoblast differentiation in mesenchymal stem cells. Biochemical and biophysical research communications. 2023. 684. 149145-149145
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Shinichirou Ito, Norio Kasahara, Kei Kitamura, Satoru Matsunaga, Toshihide Mizoguchi, Myo Win Htun, Yasuaki Shibata, Shinichi Abe, Masayuki Takano, Akira Yamaguchi. Pathological differences in the bone healing processes between tooth extraction socket and femoral fracture. Bone reports. 2022. 16. 101522-101522
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Kazuto Koresawa, Satoru Matsunaga, Atsuhiko Hikita, Hajime Okudera, Akira Yamaguchi, Yasutomo Yajima, Shinichi Abe. Micro/nanostructural properties of peri-implant jaw bones: a human cadaver study. International journal of implant dentistry. 2022. 8. 1. 17-17
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Keisuke Mitomo, Akira Yamaguchi, Takashi Muramatsu. Hypoplasia of medial pterygoid process in sphenoid bone relates to decreased mesenchymal cell proliferation in the Runx2-haploinsufficient cleidocranial dysplasia mouse model. Archives of Oral Biology. 2022. 135. 105358-105358
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MISC (103)：
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伊藤慎一郎, 笠原典夫, 北村啓, 松永智, 溝口利英, 笠原正貴, 山口朗. Skeleton-dependent stem cell diversity explored from the healing process of extraction sockets and femoral bone defects. Journal of Oral Biosciences Supplement (Web). 2022. 2022
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小倉弘之, 中村貴, 石井武展, 齋藤暁子, 小野寺晶子, 山口朗, 末石研二, 西井康, 東俊文. Apert症候群における頭蓋縫合早期癒合メカニズムの解明. 歯科学報. 2021. 120. 4
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東俊文, 中村貴, 中村貴, 斎藤暁子, 斎藤暁子, 小野寺晶子, 小野寺晶子, 末石研二, 長山和亮, 山口朗. ラミノパチーとしての鎖骨頭蓋骨異形成症病態解明から新奇薬剤治療法開発への展開. 日本再生医療学会総会(Web). 2019. 18th
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山口朗, 東俊文, 東俊文, 石原和幸, 片倉朗, 後藤多津子, 齋藤淳, 澁川義幸, 新谷誠康, 新谷誠康, et al. 顎骨疾患プロジェクトの現状と今後の展望. 歯科学報. 2017. 117. 4. 271-279
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松永智, 是澤和人, 小高研人, 松永智, 是澤和人, 小高研人, 吉成正雄, 飯村忠浩, 山口朗, 中野貴由, et al. ヒト歯科インプラント周囲顎骨における構造特性. 日本骨形態計測学会雑誌. 2017. 27. 1
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Books (1)：
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The role of BMP-2 in the olipperentiation of skeletal mesenclymal cells.
Biological mechanisms of footh movement and craniofacial adaptation 1996
Works (4)：
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骨再生における力学的負荷の役割の解析
2001 -
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骨芽細胞の分化に及すリゼトロネートの作用
2001 -
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Role of mechanical loading on bone regeneration
2001 -
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Effects of Risedronate on osteoblast differentiation
2001 -
Education (4)：
- - 1980 Tokyo Medical and Dental University
- - 1980 Tokyo Medical and Dental University Graduate School, School of Dentistry School of Dentistry
- - 1974 Tokyo Dental College College of Dentistry
- - 1974 Tokyo Dental College Faculty of Dentistry
Professional career (1)：
- - (Tokyo Medical and Dental University)
Work history (8)：
- 2015 - 現在 Tokyo Dental College Oral Health Science Center Professor
- 2004 - 2015 - 東京医科歯科大学大学院医歯学総合研究科 教授
- 1998 - 2004 - 長崎大学歯学部 教授
- 1988 - 1998 Showa University School of Dentistry
- 1988 - 1998 Associate Professor, Showa Univ. School of Dentistry
- 1998 - - Professor, Nagasaki university School of Dentistry
- 1980 - 1988 Showa University School of Dentistry
- 1980 - 1988 Assistant Professor, Showa University School of Dentistry
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Committee career (9)：
Awards (6)：
- 2017 - 日本骨代謝学会 学会賞
- 2015 - 日本歯科医学会 会長賞
- 2005 - 日本病理学会賞
- 1997 - 昭和大学上條奨学賞研究補助
- 1996 - 日本病理学会学術研究賞
- 1993 - 日本骨代謝学会学術賞
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Association Membership(s) (8)：
日本分子生物学会
, 日本口腔病理学会
, 日本発生生物学会
, American Society of Bone and Mineral Research
, 日本骨形態計測学会
, 歯科基礎医学会
, 日本病理学会
, 日本骨代謝学会
