Okutsu Mitsuharu

オクツミツハル | Okutsu Mitsuharu

Affiliation and department：
Job title： Assistant Professor

Research field (4)： Sports science , Cell biology , Physiology , Nutrition and health science

Research keywords (10)： Skeletal muscle , Muscle atrophy and hypertrophy , Autophagy , Antioxidant enzyme , Atherosclerosis , Angiogenesis , Cell migration , immunology , Chemokine receptor , Inflammation

Research theme for competitive and other funds (10)：

2021 - 2025 オートファジー基質が制御するマイオカインの同定と応用
2020 - 2023 免疫抑制補助シグナルによる新たな筋萎縮抑制機構の解明
2018 - 2022 Role of autophagy adaptor in skeletal muscle
2016 - 2019 Role of exercise-induced myokine in peripheral arterial disease
2015 - 2018 Autophagy protein protects skeletal muscle atrophy

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Papers (37)：

Mami Yamada, Mitsuharu Okutsu. Interleukin-1β triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin-induced atrophy. The Journal of Physiology (accepted). 2023
Mami Yamada, Eiji Warabi, Hisashi Oishi, Vitor A. Lira, Mitsuharu Okutsu. Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia. The FASEB Journal. 2023. 37. 9. e23156
Mitsuharu Okutsu, Mami Yamada, Ken Tokizawa, Shuri Marui, Katsuhiko Suzuki, Vitor A. Lira, Kei Nagashima. Regular exercise stimulates endothelium autophagy via IL-1 signaling in ApoE deficient mice. The FASEB Journal. 2021. 35. 7. e21698
Takahiro Onoki, Yoshihiro Izumi, Masatomo Takahashi, Shohei Murakami, Daisuke Matsumaru, Nao Ohta, Sisca Meida Wati, Nozomi Hatanaka, Fumiki Katsuoka, Mitsuharu Okutsu, et al. Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice. Redox biology. 2021. 43. 101966-101966
Mami Yamada, Chihiro Hokazono, Ken Tokizawa, Shuri Marui, Masahiro Iwata, Vitor A Lira, Katsuhiko Suzuki, Shinji Miura, Kei Nagashima, Mitsuharu Okutsu. Muscle-derived SDF-1α/CXCL12 modulates endothelial cell proliferation but not exercise training-induced angiogenesis. American journal of physiology. Regulatory, integrative and comparative physiology. 2019. 317. 6. R770-R779

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MISC (38)：

山田麻未, 奥津光晴. 運動によるマイトファジーの活性化に対するp62の役割. デサントスポーツ科学. 2022. 43. 71-79
奥津光晴, 山田麻未. 運動による骨格筋の毛細血管密度の制御に対するマイオカインの役割. デサントスポーツ科学. 2020. 41. 192-198
奥津光晴, 山田麻未. 骨格筋の恒常性維持に関する最新知見. 体力科学. 2018. 67. 3. 245-249
奥津光晴. 骨格筋の恒常性を調節する因子の探索と応用. 科学新聞. 2017
一酸化窒素による骨格筋萎縮の抑制と分子メカニズムの解明. 鈴木謙三記念医科学応用研究財団研究報告. 2017. 34. 272-275

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Books (9)：

健康づくりの新運動生理学(上田伸男、矢野博巳編集)
アイ・ケイコーポレーション 2021
進化する筋肉研究の新展開
エヌ・ティー・エス 2019
運動によるオートファジーの調節と動脈硬化症予防
体育の科学杏林書院 2016
「ニュー運動生理学II」(宮村実晴編集)
真興出版 2015
「新•スポーツ生理学」(村岡功編著)
市村出版 2015

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Lectures and oral presentations (35)：

Improved antioxidant defense system protects against chronic diseased-induced skeletal muscle atrophy
(IAGG Asia/Oceania Regional Congress 2023)
Exercise-mediated regulation of antioxidants expression in oxidative muscle requires p62 phosphorylation
(KSEP International Conferences & Annual Meeting 2023)
Nrf2 regulates skeletal muscle mass and function in a mouse model of experimental autoimmune myositis
(Experimental Biology 2021 2021)
Cancer cachexia-mediated regulation of EcSOD synthesis requires Nrf2 activation by p62 phosphorylation
(Experimental Biology 2021 2021)
Lack of muscle p62/SQSTM1 protects against high fat diet-induced muscle wasting
(Experimental Biology 2020 2020)

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Education (1)：

2002 - Tohoku University Graduate School of Medicine Disability Science

Professional career (1)：

Ph.D. (Tohoku University School of Medicine)

Work history (9)：

2020/04 - 現在 Nagoya City University Graduate School of Natural Sciences Associate Professor
2019 - 2020 Nagoya City University Graduate School of Natural Sciences
2014 - 2019 Nagoya City University Graduate School of Natural Sciences
2013 - 2014 Waseda University Faculty of Sport Sciences
2009 - 2013 Cardiovascular Research Center, Univesity of Virginia Research Associate

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Committee career (7)：

2023 - 現在日本体力医学会学術委員
2021 - 現在 Asian College of Exercise and Sports Science Assistant Secretary
2019 - 現在 Japanese Society of Physical Fitness and Health Negotiation committee
2017 - 現在 National Institute of Science and Technology Policy Professional researcher
2012 - 現在 Japanese Society of Physical Fitness and Health Councilor

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Awards (11)：

2020 - 学術論文(p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle, FASEB J, 2019)がFASEB Most Cited Articles Published Q3 2019に選出される
2020 - Nagoya City University President's Award
2020 - Nagoya City University High-impact manuscript award
2015 - Nagoya City University President's Award
2012 - University of Virginia Muscle Club Research Symposium Best Poster Award

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Association Membership(s) (7)：

日本筋学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , American Physiological Society , Japanese Society of Exercise and Immunology , International Society of Exercise and Immunology , Japanese Society of Physical Fitness and Health , 日本免疫学会

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