Nambu Hisanori

ナンブヒサノリ | Nambu Hisanori

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.pharm.hokudai.ac.jp/yakuzou/index.html

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (2)：有機合成化学 , organic chemistry

Research theme for competitive and other funds (18)：

2021 - 2024 Ring-opening cyclization of spirocyclopropanes with ylide nucleophiles for the construction of carbocycles
2018 - 2021 Divergent Synthesis of Indole Alkaloids Using Regioselective Alkylations of Enaminones
2016 - 2019 Development of environmentally benign metal carbenoid reactions: For catalysts, asymmetric reactions, natural products synthesis
2015 - 2018 Synthetic studies on natural products containing highly substituted heterocyclic skeletons using ring-opening cyclization of spirocyclopropanes
2012 - 2015 Asymmetric syntheses of biologically active heterocyclic natural products employing catalytic C-H activation strategy

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Papers (86)：

Hema Naga Lakshmi Perumalla, Tomoya Fujiwara, Maki Okada, Kanna Asakubo, Takashi Okitsu, Kengo Kasama, Hisanori Nambu, Takayuki Yakura. Efficient and Environmentally Benign Oxidative Cleavage of Pyrrolidine-2-methanols to γ-Lactams Using 2-Iodobenzamide as a Catalyst and Oxone. Chemical & pharmaceutical bulletin. 2024. 72. 1. 75-79
Takayuki Yakura, Tomoya Fujiwara, Kanna Asakubo, Hema Naga Lakshmi Perumalla, Mitsuha Uzu, Takashi Okitsu, Kengo Kasama, Hisanori Nambu. 8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine. Chemical & pharmaceutical bulletin. 2024. 72. 2. 234-239
Kota Yoshioka, Hiroki Iwasaki, Mako Hanaki, Saho Ito, Yuzuha Iwamoto, Rio Ichihara, Hisanori Nambu. A SmI<sub>2</sub>-mediated reductive cyclisation reaction using the trifluoroacetamide group as the radical precursor. Organic & Biomolecular Chemistry. 2024. 22. 10. 1988-1992
Hiroki Iwasaki, Mari Ikemoto, Haruka Shibata, Yuka Shima, Erina Himeno, Naoto Kojima, Masayuki Yamashita, Hisanori Nambu. Regioselective SmI2-Mediated Radical ipso-Substitution Cyclization for the Construction of Pyrrolophenanthridinone Skeletons: The Synthesis of Amaryllidaceae Alkaloids. CHEMICAL & PHARMACEUTICAL BULLETIN. 2023. 71. 7. 515-519
Kaito Ohta, Hiromi Ii, Chiami Moyama, Shota Ando, Hisanori Nambu, Susumu Nakata, Naoto Kojima. Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK. JOURNAL OF MEDICINAL CHEMISTRY. 2023. 66. 9. 6403-6413

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MISC (29)：

大田海斗, 藤井真人, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, 小島直人. Synthesis and Antitumor Activity of Novel Analog of Acetogenin Thiophene Analog with Triethylene Glycol in place of THF Moiety. 日本薬学会年会要旨集(Web). 2023. 143rd
細見紘幸, 小柴佐和子, 松本卓也, 安藤翔太, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, et al. Synthesis of Acetogenin Thiophene Analogs Conformationally Fixed by Cyclopentane Rings and Clarification Research of Molecular Mechanism. 日本薬学会年会要旨集(Web). 2023. 143rd
高橋達哉, 大田海斗, 竜石侑璃, 安藤翔太, 茂山千愛美, 飯居宏美, 中田晋, 岩崎宏樹, 山下正行, 南部寿則, et al. Synthesis of Thiophene Carboxamides with Alkyl Chain Comprising Ethylene Glycol Units, and Their Growth Inhibitory Activity against Glioblastoma Stem Cells. 日本薬学会年会要旨集(Web). 2023. 143rd
柿田浩輔, 古川敦, 穴田仁洋, 南部寿則, 前仲勝実, 松永茂樹, 橋本俊一. 単純ヘルペスウイルス感染阻害活性を示す糖ペプチドの合成研究. 日本薬学会年会要旨集(CD-ROM). 2016. 136th. 2. ROMBUNNO.28AB-PM065-194
柿田浩輔, 羽鳥菜々生, 古川敦, 山田友樹, 穴田仁洋, 南部寿則, 前仲勝実, 橋本俊一. 単純ヘルペスウイルス感染阻害活性を有する糖ペプチドの設計と合成. 日本糖質学会年会要旨集. 2015. 34th. 252

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Patents (1)：

Process for intramolecular radical cyclization

Books (2)：

天然物合成で活躍した反応:実験のコツとポイント
化学同人 2011
不活性結合・不活性分子の活性化:革新的な分子変換反応の開拓
化学同人 2011

Lectures and oral presentations (8)：

イリドによるスピロシクロプロパンの開裂-環化反応
(第48回反応と合成の進歩シンポジウム 2022)
高反応性スピロシクロプロパンの開裂-環化反応の開発とその応用
(日本薬学会東北支部主催第20回化学系若手セミナー 2022)
リンイリドを用いたスピロシクロプロパンの開裂-環化反応による炭素環構築法の開発
(第72回日本薬学会関西支部総会・大会 2022)
Stereoselective Construction of Actinoallolide A Franone Moiety by One-pot Reaction Sequentially Using Rh(II) Catalyst
(2022)
Catalytic Enantioselective Synthesis of (-)-epi-Conocarpan via Dirhodium(II)-Catalyzed Intramolecular C-H Insertion Process
(6th AFMC International Medicinal Chemistry Symposium 2007)

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Education (6)：

- 2004 Osaka University
- 2004 Osaka University Graduate School, Division of Pharmaceutical Sciences
- 2001 Osaka University
- 2001 Osaka University Graduate School, Division of Pharmaceutical Sciences
- 1999 Osaka University School of Pharmaceutical Sciences

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Professional career (2)：

博士(薬学) (大阪大学)
修士(薬学) (大阪大学)

Work history (6)：

2004 - 2005 Osaka University Graduate School of Pharmaceutical Sciences
2004 - 2005 Postdoctoral Fellowships of Japan Society for the Promotion of Science
2005 - - 北海道大学大学院薬学研究院助手
2005 - - Research Associate
2003 - 2004 Osaka University Graduate School of Pharmaceutical Sciences

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Committee career (1)：

2010 - 有機合成化学協会協会誌編集協力委員

Association Membership(s) (5)：

アメリカ化学会 , 日本薬学会医薬化学部会 , 日本薬学会 , 有機合成化学協会 , American Chemical Society

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