Rchr
J-GLOBAL ID：200901043388658486   Update date: Feb. 10, 2024

Shingu Takashi

シングウ タカシ | Shingu Takashi
Affiliation and department：
Tokai Gakuen University School of Health and Nutrition

About Tokai Gakuen University School of Health and Nutrition


Research field  (2)： Neurosurgery ,  Tumor biology
Research keywords  (8)： Protein quaking ,  3-D cell culture ,  glioma stem cell ,  polynuclear platinum ,  molecular targeted therapy ,  glioblastoma ,  glioma ,  autophagy
Research theme for competitive and other funds  (1)：
  • 2005 - 2006 悪性星細胞腫細胞株におけるPI3K/Akt生存シグナル経路の抑制に関する研究
Papers (25)：
  • Chao-Hsien Chen, Renee L Chin, Genevieve P Hartley, Spencer T Lea, Brian J Engel, Cheng-En Hsieh, Rishika Prasad, Jason Roszik, Takashi Shingu, Gregory A Lizee, et al. Novel murine glioblastoma models that reflect the immunotherapy resistance profile of a human disease. Neuro-Oncology. 2023. 25. 8. 1415-1427
  • Fatma Betul Aksoy Yasar, Takashi Shingu, Daniel B. Zamler, Mohammad Fayyad Zaman, Derek Lin Chien, Qiang Zhang, Jiangong Ren, Jian Hu. Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma. Frontiers in Cell and Developmental Biology. 2022. 10
  • Daniel B. Zamler, Takashi Shingu, Laura M. Kahn, Kristin Huntoon, Cynthia Kassab, Martina Ott, Katarzyna Tomczak, Jintan Liu, Yating Li, Ivy Lai, et al. Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight. 2022. 7. 12
  • Akira Inoue, Frederick S. Robinson, Rosalba Minelli, Hideo Tomihara, Bahar Salimian Rizi, Johnathon L. Rose, Takahiro Kodama, Sanjana Srinivasan, Angela L. Harris, Andy M. Zuniga, et al. Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Gastroenterology. 2021. 161. 1. 196-210
  • Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, et al. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nature Communications. 2021. 12. 1
ｍore...
MISC (8)：
  • Takashi Shingu, Jian Hu. QUAKING (QKI) LOSS ENHANCES GSC STEMNESS AND PROMOTES GLIOMAGENESIS THROUGH REGULATING INTRACELLULAR VESICLE TRAFFICKING. NEURO-ONCOLOGY. 2017. 19. 231-231
  • Jian Hu, Takashi Shingu. QKI DELETION ENHANCES SELF-RENEWAL OF GLIOMA STEM CELLS AND PROMOTES GLIOMAGENESIS. NEURO-ONCOLOGY. 2016. 18. 183-184
  • Jian Hu, Takashi Shingu, Liang Yuan. How glioma stem cells maintain sternness outside their niche. CANCER RESEARCH. 2016. 76
  • Takashi Shingu, Lindsay Holmes, Verlene Henry, Khatri Letha, Anupama E. Gururaj, Laura A. Gibson, Tiffany Doucette, Frederick F. Lang, Ganesh Rao, Liang Yuan, et al. Synergistic combination therapy with molecular targeted drugs in glioma stem-like cells. CANCER RESEARCH. 2015. 75
  • Takashi Shingu, Allen Ho, Liang Yuan, Jian Hu. QKI deletion enhances self-renewal of glioma stem cells and promotes gliomagenesis. CANCER RESEARCH. 2015. 75
ｍore...
Education (2)：
  • - 2001 Shimane Medical University Graduate School, Division of Medicine
  • - 1994 Shimane Medical University Faculty of Medicine
Professional career (1)：
  • MD., Ph.D. (Shimane Medical University)
Work history (5)：
  • 2014/10 - 2022/03 The University of Texas MD Anderson Cancer Center Department of Cancer Biology Instructor
  • 2007/04 - 2014/09 The University of Texas MD Anderson Cancer Center Research Fellow
  • 2005 - 2007 Shimane University Faculty of Medicine Lecturer
  • 2004 - 2005 Shimane University Faculty of Medicine Assistant
  • 2001 - 2002 Shimane Medical University Assistant
Association Membership(s) (5)：
American Association for Cancer Research ,  The Japan Society of Molecular Neurosurgery ,  The Japan Neurosurgical Society ,  The Japanese Pharmacological Society ,  The Japanese Biochemical Society
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