Rchr

J-GLOBAL ID：200901043405257911 Update date: Apr. 11, 2024

Ohashi Toya

オオハシトウヤ | Ohashi Toya

Affiliation and department：
Job title： Professor

Research field (3)： Fetal medicine/Pediatrics , Genetics , Medical biochemistry

Research keywords (3)： Gene Therpay , Inborn Error of metabolism , Pediatrics

Research theme for competitive and other funds (48)：

2019 - 2022 細胞送達能を高めた改変型酵素を用いるムコ多糖症II型の造血幹細胞遺伝子治療法開発
2018 - 2021 Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosis
2018 - 2020 GM1ガングリオシドーシスの造血幹細胞を標的とした遺伝子治療法の開発
2017 - 2020 ライソゾーム病(ファブリ病含む)に関する調査研究
2017 - 2020 小児神経疾患・先天代謝異常症に対する遺伝子治療法開発

2015 - 2019 Preparation of device for mucopolysaccharidosis treatment using iPS cells and gene modification system

2017 - 2019 ムコ多糖症II型の造血幹細胞を標的とした遺伝子治療法の実用化研究

2015 - 2018 Improvement of peripheral neuropathy by Adeno-associated virus vector expressing a-galactosidase A in murine Fabry model

2015 - 2018 Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation

2014 - 2017 Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect

2014 - 2017 ライソゾーム病(ファブリ病含む)に関する調査研究

2012 - 2016 Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases

2013 - 2016 国際共同治験に基づき小児稀少難病に対する遺伝子・細胞治療の実施とその支援体制の際日

2010 - 2014 ライソゾーム病(ファブリ病含む)に関する調査研究

2007 - 2010 ライソゾーム病(ファブリ病含む)に関する調査研究

2004 - 2007 ライソゾーム病(ファブリ病含む)に関する調査研究

2004 - 2005 ゴーシェ病の中枢神経症状発現機序及び治療に関する研究

2003 - 2005 脳血管関門を通過する酵素製剤の開発に関する研究

2002 - 2004 Neuropathological and therapeutic studies on adult motoneuron degeneration using rat peripheral nerve avulsion models

2002 - 2004 Development of novel therapy and elucidation of pathophysiology for genetic leukodystrophy

2002 - 2003 Cloning of a novel tumor suppressor gene in Wilms' tumor associated with chromosome instability

2001 - 2002 Gene therapy for neurogical abnormality using mouse model of lipidosis

2000 - 2001 Adenoviral gene transfer of neurotrophic factors to injured adult motoneurons

1999 - 2001 Molecular Pathogenesis of Brain Damage and Gene Therapy in Genetic Leukodystrophy

1999 - 2001 Prenatal Diagnosis of Ingenited Metabolic Disorders Using Maternal Blood

1999 - 2000 Treatment for congenital metabolic disorder with brain dysfunction.

1999 - 2000 Gene therapy for central nervous involvement of Gaucher disease

1999 - 2000 Gene therapy for Krabbe disease with microglial cells derived from brain

1999 - 2000 Gene therapy for brain damage using animal models with lipidoses

1999 - 2000 Gene Therapy for Sly disease using AAV vector.

1998 - 1999 Gene therapy for CNS involvement of Lysosomal storage disease using various viral vector

1997 - 1998 ADENOVIRAL VECTORを使用した肝臓に対する遺伝子治療における投与条件の基礎的検討

1997 - 1998 Studies of inherited neurodegenerative disease ; mutation analysis and gene therapy

1997 - 1998 Gene therapy for Sly disease

1997 - 1998 Gene therapy for neuronopathic Gaucher disease

1996 - 1997 The cause of neuropathochemistry of inherited Neurodegeneration

1995 - 1996 Gene Therapy for Lysosomal Strage Disease

1995 - 1996 Gene Therapy toward to nuerodegenerative disorders using fetal hematopoietic stem cells transplantation

1994 - 1996 Molecular Analysis and Gene Therapy in Inherited dysmyelinating disorder

1995 - 1995 リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療

1994 - 1994 リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療

1993 - 1994 Gene therapy for inherited neurodegenerative disease using fetal bone marrows stem cell transplantation.

1992 - 1993 Studies of genetic analysis and gene therapy for myelin-associated disorders.

1992 - 1992 Gaucher病の遺伝子治療に関する研究

1990 - 小児代謝異常の遺伝子治療

1986 - 1988 c DNA cloning for human Arylsulfatase A

1984 - 1984 ライソゾーム病患者の神経細胞, 皮膚線維芽細胞の細胞骨格構築異常の解明に関して

Gene therapy

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Papers (174)：

櫻井謙, 西山由梨佳, 畑純一, 吉丸大輔, 小林正久, 小林博司, 岡野ジェイムス洋尚, 大橋十也, 大石公彦. 磁気共鳴画像の脳領域別体積測定法を用いたファブリー病の四肢末端痛に関連する病変部位の同定. 日本先天代謝異常学会雑誌. 2022. 38. 180-180
Yohta Shimada, Natsumi Ishii, Takashi Higuchi, Motohito Goto, Toya Ohashi, Hiroshi Kobayashi. A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy. Gene therapy. 2022
Toshiki Tsunogai, Toya Ohashi, Yohta Shimada, Takashi Higuchi, Ayaka Kimura, Ayako M Watabe, Fusao Kato, Hiroyuki Ida, Hiroshi Kobayashi. Hematopoietic stem cell gene therapy ameliorates CNS involvement in murine model of GM1-gangliosidosis. Molecular therapy. Methods & clinical development. 2022. 25. 448-460
Ikuko Anan, Toru Sakuma, Eiko Fukuro, Satoshi Morimoto, Ayumi Nojiri, Makoto Kawai, Ken Sakurai, Masahisa Kobayashi, Hiroshi Kobayashi, Hiroyuki Ida, et al. The role of native T1 values on the evaluation of cardiac manifestation in Japanese Fabry disease patients. Molecular genetics and metabolism reports. 2022. 31. 100858-100858
角皆季樹, 大橋十也, 嶋田洋太, 樋口孝, 木村文香, 松島小貴, 渡部文子, 小林博司. 造血幹細胞を標的としたレンチウイルスベクターを用いたGM1ガングリオシドーシスの遺伝子治療法の開発. 東京慈恵会医科大学雑誌. 2021. 136. 6. 136-137

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MISC (525)：

Shirai Yoshihiro, Sugano Hiroshi, Sato Shun, Hamatani Shigeharu, Horiuchi Takashi, Saito Nobuhiro, Hamura Ryoga, Taniai Tomohiko, Yanagaki Mitsuru, Takada Naoki, et al. Prognostic significance of thrombomodulin expression in pancreatic cancer(和訳中). 日本肝胆膵外科学会・学術集会プログラム・抄録集. 2021. 32回. 368-368
Mitsuru Yanagaki, Yoshihiro Shirai, Ryoga Hamura, Tomohiko Taniai, Yohta Shimada, Takashi Horiuchi, Naoki Takada, Nobuhiro Saito, Toya Ohashi, Toru Ikegami. Functional analysis of sphingolipid metabolism-related cell apoptosis in pancreatic cancer cells. CANCER SCIENCE. 2021. 112. 440-440
三浦茜, 岡部匡裕, 春原浩太郎, 山本泉, 坪井伸夫, 大橋十也, 井田博幸, 衞藤義勝, 横尾隆. 酵素補充療法を行ったファブリー病7例の長期腎予後と腎組織学的変化の関連性. 日本腎臓学会誌(Web). 2021. 63. 4
Masayoshi Yamaoka, Yasuharu Akasaki, Jun Takei, Masaharu Akiyama, Tetsunori Tasaki, Toya Ohashi, Hiroyuki Ida, Takaaki Yanagisawa. PHASE I/II TRIAL OF IMMUNOTHERAPY WITH FUSIONS OF DENDRITIC CELLS AND TUMOR CELLS FOR RELAPSED OR REFRACTORY BRAIN TUMORS IN CHILDREN AND YOUNG ADULTS. NEURO-ONCOLOGY. 2020. 22. 362-362
Tomohiko Taniai, Yoshihiro Shirai, Yohta Shimada, Ryoga Hamura, Mitsuru Yanagaki, Naoki Takada, Kazuhito Tsuboi, Yasuo Okamoto, Toya Ohashi, Katsuhiko Yanaga. Inhibition of Sphingolipid Metabolism Has Ceramide-Induced Anti-Tumor Effect on Pancreatic Cancer Cells. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS. 2020. 231. 4. S270-S270

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Books (15)：

イラストレイテッド統合臨床基礎医学
丸善出版 2018 ISBN:9784621302446
ファブリー病
ドクターサロン 2018
連載ノーベル賞と小児疾患【第6回】1974年ノーベル生理学・医学賞リソソーム, ペルオキシソームの発見そしてオートファジーの名づけの親,
小児内科 2018
特集先端医療の現状と腎疾患への応用【先端医療の各論】遺伝子治療の現状,
腎と透析 2018
特集小児診療ガイドラインの読み解き方-ガイドラインの背景, 使い方を中心に序-今回の企画について,
小児内科 2018

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Lectures and oral presentations (84)：

Fabry病の診断と治療
(東京Webセミナー 2020)
遺伝子治療の最前線~遺伝性疾患を中心に~, (特別講演)
(第112回東海臨床遺伝・代謝談話会 2020)
Current status of Japanese gene and cell therapy.
(International Forum on Regulatory Science for Advanced Therapy Medicinal Products (ATMPs))
リプレガルの市販後調査, (ランチョンセミナー3 ファブリー病Update)
(第61回日本先天代謝異常学会総会)
先天代謝異常症に対する遺伝子治療の現状,(特別講演1)
(第61回日本先天代謝異常学会総会)

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Education (1)：

1975 - 1981 The Jikei University School of Medicine Faculty of Medicine

Professional career (1)：

Doctor of Medical Science

Work history (13)：

2021/04 - 現在 The Jikei University School of Nursing Department of Human Health Science and Therapeutics Professor
2019/04 - 2022/03 The Jikei University School of Medicine Vice President
2014/04 - 2021/03 The Jikei University School of Medicine Research Center for Medical Sciences Director
2007/08 - 2021/03 Research Center for Medical Sciences, The Jikei University School of Medicine Division of Gene Therapy, Department of Pediatrics Professor
2001/08 - 2007/07 Jikei University

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Committee career (7)：

2007/06 - 現在 Japan Society of Gene and Cell Therapy Board of directors
1996 - 現在 Japanese society of Inborn error of metabolism Councilor
2008/06 - 2015/05 American Society of Geen Therapy Membership committee member
2003/01 - 2015/05 European Society of Gene Therapy Scientific committee member
2004/04 - 2014/04 Japanese Society of Pediatrics Representative

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Awards (7)：

2019/10 - 日本先天代謝異常学会学会賞
2011/03 - 2nd Prize Poster Group Basic Science 9th international symposium on lysosomal storage diseases in Madrid, Spain
2009/03 - 2nd Prize Poster Group Basic Science 9th international symposium on lysosomal storage diseases in Frankfurt, Germany, 2009
2008/10 - Poster award, 9th European Round Table on Fabry disease, Athens, Greece
2007/03 - 小児医学川野賞

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Association Membership(s) (6)：

日本先天代謝異常学会 , 日本小児科学会 , 日本遺伝子細胞治療学会 , The Japan Society of Gene Therapy , The Japan Pediatric Society , Japanese Society of Inherited Metabolic Disease

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