Sakaguchi Takemasa

サカグチタケマサ | Sakaguchi Takemasa

Affiliation and department：
Job title：教授

Research field (1)： Virology

Research keywords (10)： persimmon tannin , anti-virus , accessory protein , interferon , morphogenesis , Protein three dimensional structure , SARS-CoV-2 , hepatitis B virus , influenza virus , Sendai virus (HVJ)

Research theme for competitive and other funds (28)：

2022 - 2026 核移植クローン技術に基づく免疫応答・疾患発症機構の包括的研究基盤
2022 - 2025 ヒトゲノム内在性ウイルス配列によるX精子運動能制御の解明
2021 - 2025 食品系バイオマスを活用したヘルスケア製品の開発
2021 - 2024 免疫抑制薬がSARS-CoV-2ゲノム複製とT細胞応答へ及ぼす影響の解明
2020 - 2023 Elucidation of virus multiplication mechanism by a novel hepatitis B virus replication system using stabilized polymerase

2019 - 2022 Development of simple and efficient techniques to erase viral vectors by applying viral interference

2017 - 2020 Development of new concept viral vectors exerting both vaccine and adjuvant activities

2017 - 2020 Multimodal therapy by microRNA-encoding oncolytic virus

2016 - 2019 Elucidation of interactions between paramyxoviral infection and host innate immunity

2015 - 2017 Anti-tumor effects by recombinant STAT3-inhibiting Sendai virus

2014 - 2017 Fluorescent tumor cell detection by tumor-specific virus VSV for precise osteosarcoma resection

2013 - 2016 Elucidation of mechanisms of innate immune stimulation and evasion by RNA viruses

2013 - 2016 Analysis of the mechanism of severe pneunomia by influenza virus infection

2012 - 2015 Analysis of structure and function of viral proteins that suppress innate immunity

2010 - 2012 アクセサリー蛋白質によるパラミクソウイルスの多面的な自然免疫回避戦略

2009 - 2011 Regulation of genome replication of negative-strand RNA virus by an accessory protein

2005 - 2009 Analysis of the mechanism of cell cycle-dependent virus infection and cellular response

2007 - 2008 Investigation of mechanism of paramyxovirus budding with accessory proteins by using vi rus reconstitution systems

2006 - 2007 Isolated limb perfusion for vesicular stomatitis virus delivery in sarcoma-bearing rats

2004 - 2006 増殖性水疱性口内炎ウイルスベクターを用いた肝腫瘍に対する腫瘍標的遺伝子治療の開発

2004 - 2005 ウイルスゲノムRNAのウイルス粒子への選択的取り込み機構

2003 - 2005 Investigation for signals and host factors related to paramyxovirus budding.

2003 - 2003 パラミクソウイルスの出芽に関わるシグナルと宿主因子の解明

2000 - 2003 Regulation of paramyxovirus gene expression and pathogenesis by host factors.

2002 - 2002 細胞傷害性と病原性に関わるセンダイウイルス・プロモーターの解析とベクターへの応用

2000 - 2001 Analysis of pathogenesis of a virulent field isolate of Sendai virus by using a virus recovery from cDNA

1998 - 1999 A structure-functional analysis of the paramyxovirus M protein by using a virus recovery system from cDNA

1997 - 1998 樹状細胞へのターゲッティングによる新しい呼吸器ウイルスワクチンの開発

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Papers (174)：

Lawal-Ayinde, Basirat Mojisola, Morita, Tomoko, Oda, Kosuke, Nazmul, Tanuza, Kurose, Miuko, Nomura, Toshihito, Yamamoto, Akima, Higashiura, Akifumi, Akita, Tomoyuki, Tanaka, Junko, et al. Virus purification highlights the high susceptibility of SARS-CoV-2 to a chlorine-based disinfectant, chlorous acid. PLOS ONE. 2023. 18. 7. e0288634-e0288634
Tanuza Nazmul, Basirat M. Lawal-Ayinde, Tomoko Morita, Reiko Yoshimoto, Akifumi Higashiura, Akima Yamamoto, Toshihito Nomura, Yukiko Nakano, Makoto Hirayama, Hiroshi Kurokawa, et al. Capture and neutralization of SARS-CoV-2 and influenza virus by algae-derived lectins with high-mannose and core fucose specificities. Microbiology and Immunology. 2023. 67. 7. 334-344
Fukushi, Masaya, Ohsawa, Ryosuke, Okinaka, Yasushi, Oikawa, Daisuke, Kiyono, Tohru, Moriwaki, Masaya, Irie, Takashi, Oda, Kosuke, Kamei, Yasuhiro, Tokunaga, Fuminori, et al. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection. PLOS ONE. 2023. 18. 6. e0287545-e0287545
Shitaoka, Kiyomi, Higashiura, Akifumi, Kawano, Yohei, Yamamoto, Akima, Mizoguchi, Yoko, Hashiguchi, Takao, Nishimichi, Norihisa, Huang, Shiyu, Ito, Ayano, Ohki, Shun, et al. Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants. COMMUNICATIONS BIOLOGY. 2023. 6. 1. 395-395
Sukmana, Ndaru Candra, Sugiarto, Jun, Shinogi, Jun, Kojima, Tatsuhiro, Higashiura, Akifumi, Yamamoto, Akima, Sakaguchi, Takemasa, Sadakane, Masahiro. Solid-state Thermal Transformation of Methylammonium Monomolybdate to Polyoxomolybdates and their Applications as Staining Reagents for Transmission Electron Microscopy Observations of Viruses. CHEMISTRY LETTERS. 2023. 52. 3. 167-171

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MISC (4)：

入江崇, 酒井宏治, 坂口剛正. ウイルスベクターワクチンの現状と展望. BIO Clinica. 2019. 34. 2. 223-227
小田康祐, 野村俊仁, 木平清人, 岡部隆義, 東浦彰史, 的場康幸, 坂口剛正. パラミクソウイルスCタンパク質を標的とした抗ウイルス薬の開発. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
Oda Kosuke, Ootake Rina, Matoba Yasuyuki, Irie Takashi, Sakaguchi Takemasa. 2P-068 Molecular mechanism of Sendai virus C protein to propagate the virus during the infection. 2015. 67. 191-191
Ken Nishimura, Hiroaki Segawa, Takahiro Goto, Mariko Morishita, Takemasa Sakaguchi, Tetsuya Yoshida, Kozo Takayama, Mahito Nakanishi. Persistent gene expression from a novel RNA virus vector based on Sendai virus cl.151 STRAIN. JOURNAL OF GENE MEDICINE. 2006. 8. 12. 1457-1457

Patents (15)：

ウイルス不活性化剤
抗ウイルス性物品外層用樹脂組成物、成形体、抗ウイルス性物品
抗ウイルス剤および抗ウイルス用組成物
ケイ素含有化合物を含む抗菌剤組成物及び抗ウィルス剤組成物、並びに抗菌化方法、洗浄・洗口方法、抗菌剤及び抗ウィルス剤固定化方法
抗ウイルス剤および抗ウイルス用組成物

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Books (18)：

mRNAの制御機構の解明と治療薬・ワクチンへの応用
技術情報協会 2023 ISBN:9784861049378
体と心保健総合大百科〈小学校編〉2022
株式会社少年写真新聞社 2022
体と心保健総合大百科〈中・高編〉2022
株式会社少年写真新聞社 2022
創薬研究者がこれだけは知っておきたい最新のウイルス学
技術情報協会 2021 ISBN:9784861048555
心と体保健総合大百科<小学校編>2021
少年写真新聞社 2021 ISBN:9784879817327

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Lectures and oral presentations (363)：

Changes in Host Biomarkers in Myocardial Infarction Patients Due to Microorganisms and Statins
(International conference Contemporary Pharmacy: Issues, Challenges and Expectations 2024 (ICP2024) 2024)
SARS-CoV-2変異株毎のウイルス培養におけるウイルス量と細胞変性効果の推移
(第35回日本臨床微生物学会総会・学術集会 2024)
BEACHドメイン含有タンパク質(BDCP)の新機能:RNAウイルス誘導性細胞死の制御と非アルコール性脂肪性肝疾患への寄与
(第46回日本分子生物学会年会 2023)
多様な入試を通じて未来の医療リーダーを迎える広島大学医学部
(駿台2023年度特別イベント広島大学特別講演会 2023)
Synthesis and Cell-Based Evaluation of Umifenovir Analogues as Anti-SARS- CoV-2 Agents
(The International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC) 15th 2023)

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Education (4)：

1986 - 1987 Nagoya University Laboratory of Molecular Pathogenesis Graduate School of Medical Sciences
1986 - 1987 Nagoya University Graduate School of Medical Sciences Laboratory of Molecular Pathogenesis
1979 - 1985 Nagoya University School of Medicine Faculty of Medicine
1979 - 1985 Nagoya University Faculty of Medicine School of Medicine

Professional career (1)：

Doctor of Medicine (Hiroshima University)

Work history (7)：

2019/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Professor
2009/04/01 - 2019/03/31 Hiroshima University Professor
2007/04/01 - 2009/03/31 Hiroshima University Associate Professor
1998/05/01 - 2007/03/31 Hiroshima University Associate Professor
1996/09/01 - 1998/04/30 Hiroshima University Assistant Professor

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Committee career (22)：

2020/04 - 2026/03 広島県広島県感染症予防研究調査会委員
2010/04 - 2026/03 中国四国ウイルス研究会中国四国ウイルス研究会幹事
2009/04 - 2026/03 広島県地域保健対策協議会広島県地域保健対策協議会理事
2008/04 - 2026/03 広島市保健部保健医療課広島市感染症対策協議会委員
2018/04 - 2021/06 広島市医師会看護専門学校医療専門課程非常勤講師

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