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J-GLOBAL ID：200901043833031138   Update date: Jan. 31, 2024

Watashi Koichi

ワタシ コウイチ | Watashi Koichi
Affiliation and department：
National Institute of Infectious Diseases Research Center for Drug and Vaccine Development

About National Institute of Infectious Diseases Research Center for Drug and Vaccine Development


Job title： Director, Division of Drug Development
Other affiliations (2)：
Research field  (3)： Virology ,  Pharmaceuticals - health and biochemistry ,  Molecular biology
Research keywords  (10)： HBV ,  HCV ,  hepatitis D virus ,  coronavirus ,  poxvirus ,  Chemical Biology ,  Anti-viral ,  virus dynamics ,  modality ,  anti-infectives
Research theme for competitive and other funds  (9)：
  • 2021 - 2024 Structure and functional analysis of the SARS-CoV-2 Nucleocapsid Protein
  • 2020 - 2023 Molecular mechanism, dynamics, and interaction with environment in the hepatitis B virus entry system
  • 2017 - 2020 Mechanistic analysis of hepatitis B virus entry and the host factors using new cell culture systems
  • 2016 - 2019 Systems Virology for understanding viral pathogenesis
  • 2014 - 2018 Analysis of regulation mechanisms of hepatitis B virus life cycle by kinases and post-translational modifications
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Papers (207)：
  • Wakana Yamashita, Shinjiro Ojima, Azumi Tamura, Aa Haeruman Azam, Kohei Kondo, Zhang Yuancheng, Longzhu Cui, Masaki Shintani, Masato Suzuki, Yoshimasa Takahashi, et al. Harnessing a T1 phage-derived spanin for developing phage-based antimicrobial development. BioDesign Research. 2024
  • Kento Fukano, Kousho Wakae, Naganori Nao, Masumichi Saito, Akihito Tsubota, Takae Toyoshima, Hideki Aizaki, Hiroko Iijima, Takahiro Matsudaira, Moto Kimura, et al. A versatile method to profile hepatitis B virus DNA integration. Hepatology communications. 2023. 7. 12
  • Adi Ariffianto, Lin Deng, Takayuki Abe, Chieko Matsui, Masahiko Ito, Akihide Ryo, Hussein Hassan Aly, Koichi Watashi, Tetsuro Suzuki, Masashi Mizokami, et al. Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication. Journal of virology. 2023. 97. 10. e0128723
  • Haruyo Aoyagi, Hiroko Iijima, Eman S Gaber, Takuma Zaitsu, Mami Matsuda, Kosho Wakae, Koichi Watashi, Ryosuke Suzuki, Takahiro Masaki, Jeffrey Kahn, et al. Hepatocellular organellar abnormalities following elimination of hepatitis C virus. Liver international : official journal of the International Association for the Study of the Liver. 2023. 43. 8. 1677-1690
  • Mizuki Oshima, Frank Stappenbeck, Hirofumi Ohashi, Masashi Iwamoto, Kento Fukano, Atsuto Kusunoki, Xin Zheng, Feng Wang, Ryo Morishita, Hideki Aizaki, et al. Selective inhibition of hepatitis B virus internalization by oxysterol derivatives. Biochemical and biophysical research communications. 2023. 675. 139-145
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MISC (50)：
  • 赤澤大輔, 下島昌幸, 朴ウンシル, 前田健, 海老原秀喜, 高橋宜聖, 渡士幸一. Analysis of target antigens for neutralizing antibodies against mpox virus. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
  • 岩波翔也, 山本将太朗, 日紫喜隆行, 赤澤大輔, 大橋啓史, 森田武志, 渡士幸一, 岩見真吾. Mathematical modeling for quantitative assessment of anti-mpox virus drug candidates. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
  • 北村秀智, 北村秀智, 倉崎晴彰, 倉崎晴彰, 大内政輝, 長友一剛, 大橋啓史, 岩田(吉河)奈織子, 志和(須藤)希, 坂井祐介, et al. Preclinical and clinical characterization of PA-001, a macrocyclic peptide that targets the S2 subunit of SARS-CoV-2 spike protein. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
  • 日紫喜隆行, 森田武志, 赤澤大輔, 大橋啓史, 朴ウンシル, 片岡紀代, 御舩淳紀, 塩野谷果歩, 塩野谷果歩, 土本佳奈, et al. Inosine monophosphate dehydrogenase as a potential target for anti-mpox virus agent. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
  • 河村達郎, 河村達郎, 大内政輝, 長澤孝行, 大橋啓史, 岩田(吉河)奈織子, 志和(須藤)希, 坂井祐介, 松井克磨, 松本正俊, et al. Identification and in vivo therapeutic efficacy of PA-001, a macrocyclic peptide that targets the S2 subunit of SARS-CoV-2 spike protein. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2023. 70th
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Professional career (2)：
  • Ph.D. (Kyoto University)
  • Master (Pharmaceutical Sciences) (Kyoto University)
Work history (8)：
  • 2022/04 - 現在 (併任)早稲田大学大学院 先進理工学研究科 客員教授
  • 2021/04 - 現在 National Institute of Infectious Diseases Research Center for Drug and Vaccine Development Director, Division of Drug Development
  • 2019/04 - 現在 Tokyo University of Science Graduate School of Science and Technology Department of Biological Sciences (Dual Appointment) Visiting Professor
  • 2009/12 - 2021/03 National Institute of Infectious Diseases Department of Virology II Senior Researcher
  • 2011/04 - 2019/03 Tokyo University of Science Graduate School of Science and Technology Department of Biological Sciences (Dual Appointment) Visiting Associate Professor
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Awards (7)：
  • 2023 - 国際B型肝炎ウイルス学会(2023年 神戸) 学会長
  • 2017 - 日本肝臓学会 MSDアワード
  • 2016 - 大正富山Award
  • 2013 - Liver Forum in Kyoto 研究奨励
  • 2012 - 日本肝臓学会STC Young Investigator Award
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Association Membership(s) (5)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  Japanese Association of Antiviral Therapy ,  THE JAPAN SOCIETY OF HEPATOLOGY ,  日本分子生物学会 ,  日本ウイルス学会
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