Furukawa Toru

フルカワトオル | Furukawa Toru

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.med.tohoku.ac.jp/about/laboratory/188.html , https://www.med.tohoku.ac.jp/english/about/laboratory/188.html

Research field (4)： Medical biochemistry , Molecular biology , Experimental pathology , Human pathology

Research keywords (1)： cancer

Research theme for competitive and other funds (25)：

2022 - 2026 Elucidation of the mechanism of intractability of pancreatobiliary cancers using patients-derived organoids
2021 - 2025 オルガノイドとオミックス解析による頭頸部非扁平上皮癌の個別化医療モデルの開発
2021 - 2024 A novel therapeutic strategy for pancreatic and biliary tract cancer by targeting the intestinal microbiota for anti-tumor immune activation
2020 - 2023 DUSP6不活化膵臓がんの治療戦略
2019 - 2022 Molecular signature-based classification of circulating tumor cells and its clinical application for refinement of multidisciplinary treatment of pancreatic cancer.

2016 - 2021 Identification of molecular targets by analysis of signaling networks in pancreatic cancer

2016 - 2020 Comparing pancreatic ductal adenocarciinoma and cholangiocarcinoma to elucidate the mechanism of carcinogenesis

2016 - 2019 Challenging of development of cancer cell specific treatment by means of somatic genome editing

2016 - 2019 Functional significance of the RHOA mutation in gastric cancer

2016 - 2019 Analysis of pathogenic mechanisms of IPMN using GNAS gene modified mousepathogenic mechanisms

2014 - 2017 Whole exome sequencing ot intraductal tubulopapillary neoplasm of the pancreas

2012 - 2015 Identification of molecular targets associated with activation of GPCR signal pathway in pancreatic cancer

2012 - 2015 Identification of susceptible genes in familial pancreatic cancer in Japan

2010 - 2011 The relationship between fascin-overexpression and RAS signaling pathway in pancreatic cancer

2007 - 2009 Identification of molecular targets for human pancreatic cancer

2004 - 2005 耳管粘膜下における脂肪細胞の分化誘導-耳管開放症の根本的治療法の開発-

2003 - 2004 Basic and clinical research for prevention of carcinogenesis aiming at extinction of head and neck squamous cell carcinoma.

2003 - 2004 Curing of pancreatic cancer by DUSPG/MKP-3

2001 - 2002 Experimental gene therapy employing DUSP6/MKP-3 for pancreatic cancer

1999 - 2000 Identification of tumor suppressor genes by means of a genomic clone-transfer

1998 - 2000 Adjuvant gene therapy for pancreatic cancer using hybrid type liposome vector

1998 - 1999 Establishment of efficient treatment strategies for the pancreatic cancer based on its molecular characteristics

1998 - 1999 Towards establishment of gene therapy for human pancreatic and endometrial cancers

1998 - 1999 Establishment of novel efficient methods for pancreatic cancer patients based on genetic abnormality.

1997 - 1998 膵臓がんの発生・進展に関与する第6番染色体長腕上のがん抑制遺伝子の同定

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Papers (451)：

Yuko Omori, Shuichi Aoki, Yusuke Ono, Takashi Kokumai, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, et al. Clonal analysis of metachronous double biliary tract cancers. The Journal of pathology. 2024. 263. 1. 113-127
Yasuni Nakanuma, Yasunori Sato, Yuko Kakuda, Yoshiki Naito, Yuki Fukumura, Mana Fukushima, Hiroshi Minato, Shinichi Aishima, Nobuyuki Ohike, Toru Furukawa. Interobserver agreement of pathologic classification and grading of tumoral intraductal pre-invasive neoplasms of the bile duct. Annals of Diagnostic Pathology. 2024. 69. 152247-152247
Keigo Murakami, Taito Itoh, Yasunobu Okamura, Kengo Kinoshita, Hideki Ota, Michiaki Unno, Takashi Kamei, Toru Furukawa. Molecular pathological demonstration of an unusual angiosarcoma-like dedifferentiation pattern in hepatocellular carcinoma. Pathology international. 2024
Ruri Yamaguchi, Hiromu Morikawa, Jun Akatsuka, Yasushi Numata, Aya Noguchi, Takashi Kokumai, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, et al. Machine Learning of Histopathological Images Predicts Recurrences of Resected Pancreatic Ductal Adenocarcinoma With Adjuvant Treatment. Pancreas. 2023
Yuki Ishikawa, Ryusuke Saito, Keigo Murakami, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroaki Mitsugashira, Kazuki Degawa, Yoshinobu Kobayashi, et al. Small Intestinal Adenocarcinoma Arising at the Anastomotic Site after Kasai Operation for Biliary Atresia: A Case Report and Literature Review. The Tohoku journal of experimental medicine. 2023. 261. 4. 267-272

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MISC (224)：

Yuko Omori, Yusuke Ono, Takashi Kokumai, Fumiko Date, Ryota Higuchi, Goro Honda, Yusuke Mizukami, Takanori Morikawa, Michiaki Unno, Toru Furukawa. Molecular Phenotyping and the Combinatorial System by the Number of Accumulated Gene Alterations of Intraductal Papillary Mucinous Neoplasms Stratifies the Risk of Invasion and Outcome: New Insight for Management Strategy. LABORATORY INVESTIGATION. 2023. 103. 3. S1520-S1520
鈴木修司, 大森優子, 廣瀬勝也, 小野裕介, 唐崎秀則, 下田貢, 永川裕一, 水上裕輔, 古川徹. 残膵癌における先行膵癌との分子病理学的および臨床病理学的検討. 膵臓(Web). 2023. 38. 3
Yuko Omori, Yusuke Ono, Takashi Kokumai, Fumiko Date, Ryota Higuchi, Goro Honda, Yusuke Mizukami, Takanori Morikawa, Michiaki Unno, Toru Furukawa. Molecular phenotyping and risk stratification of intraductal papillary mucinous neoplasms. CANCER RESEARCH. 2022. 82. 22. 170-170
平野直大, 伊関雅裕, 水間正道, 野口彩, 青木修一, 井上亨悦, 中山瞬, 三浦孝之, 石田晶玄, 大塚英郎, et al. 切除可能境界膵体部癌に対して術前治療により病理学的完全奏効が得られた1例. 日本消化器病学会東北支部例会プログラム・抄録集. 2022. 213回. 71-71
吉田拓矢, 中目亜矢子, 大越明, 東健次郎, 石井亮, 石川智彦, 古川徹, 小川武則, 香取幸夫. 本邦におけるHPV関連中咽頭癌予防に向けたHPV16 Virus Variant調査とワクチン効果予測. 日本耳鼻咽喉科頭頸部外科学会会報. 2022. 125. 4. 749-749

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Books (33)：

Pancreatic intraepithelial neoplasia. Digestive System Tumorus WHO Classification of Tumours Series, 5th ed; vol. 1. Edited by the WHO Classification of Tumours Editorial Board. IARC press, Lyon
2019
Pancreatic intraductal papillary mucinous neoplasm. Digestive System Tumorus WHO Classification of Tumours Series, 5th ed; vol. 1. Edited by the WHO Classification of Tumours Editorial Board. IARC press, Lyon
2019
Pancreatic intraductal oncocytic papillary neoplasm. Digestive System Tumorus WHO Classification of Tumours Series, 5th ed; vol. 1. Edited by the WHO Classification of Tumours Editorial Board. IARC press, Lyon
2019
Pancreatic intraductal tubulopapillary neoplasm. Digestive System Tumorus WHO Classification of Tumours Series, 5th ed; vol. 1. Edited by the WHO Classification of Tumours Editorial Board. IARC press, Lyon
2019
Pancreatic mucinous cystic neoplasm. Digestive System Tumorus WHO Classification of Tumours Series, 5th ed; vol. 1. Edited by the WHO Classification of Tumours Editorial Board. IARC press, Lyon
2019

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Lectures and oral presentations (421)：

胆管内乳頭状腫瘍(IPNB)は臨床病理学的因子および分子異常と関連した2 つのType に分けられる.
(第 56 回日本胆道学会学術集会(オンライン) 2020)
エキスパートパネルにおける病理医の役割分子病理講習会
(第109回日本病理学会総会(オンライン) 2020)
NTRK3に2箇所のbreak pointを有し非典型的組織像を示した唾液腺分泌癌症例: 分泌癌10例の分子病理学的検討.
(第109回日本病理学会総会 2020)
膵癌細胞株におけるMAPK pathwayに関連したlong non-coding RNAの解析.
(第109回日本病理学会総会 2020)
IPMN組織亜型における遺伝子異常についての相互関係の分子病理学的解析.
(第109回日本病理学会総会 2020)

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Education (1)：

1980 - 1986 Akita University School of Medicine

Professional career (1)：

医学博士 (東北大学)

Work history (5)：

2017/04 - 現在 Tohoku University Graduate School of Medicine Professor
2010/04 - 2017/03 Tokyo Women's Medical University Professor
2008/04 - 2010/03 Tokyo Women's Medical University Professor
2005/12 - 2008/03 Tokyo Women's Medical University Associate Professor
1996/07 - 2005/11 Tohoku University School of Medicine Assistant Professor

Awards (1)：

2019/05 - Japan Pathology Award

Association Membership(s) (7)：

Japan Pancreas Society , 日本消化器病学会 , 日本人類遺伝学会 , 国際膵臓学会 , アメリカ癌学会 , 日本病理学会 , 日本癌学会

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