Rchr
J-GLOBAL ID:200901044505508756
Update date: Apr. 15, 2024
Nakayama Hideki
ナカヤマ ヒデキ | Nakayama Hideki
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www2.kuh.kumamoto-u.ac.jp/oralsurgery/
Research field (1):
Surgical dentistry
Research keywords (10):
Air plasma-activated medium
, 腫瘍免疫
, 腫瘍融解ウイルス
, ペプチドワクチン
, 治療抵抗性
, tumor microenvironment
, metastasis
, radioresistance
, drug resistance
, oral cancer
Research theme for competitive and other funds (27):
- 2021 - 2024 Verification study and therapeutical utilization for implementation of real time monitoring in oral cancer
- 2018 - 2021 治療抵抗性口腔癌の根絶を目指したIL-6シグナル阻害による革新的放射線療法の開発
- 2017 - 2020 Relationship between antitumor immunity and lymph node immune environment in oral caner
- 2016 - 2018 Anticancer agent-resistant mechanism elucidation and new cure development through cytokine in oral cancer.
- 2016 - 2018 Investigation of the mechanisms of regulating tumor microenvironment by secreted micro RNA from intractable oral cancer, and development a new treatment strategy
- 2015 - 2018 Development of cancer immunotherapy using tumor-associated antigen-derived long peptides and liberation from immune suppression mediated trough IL-6 signaling
- 2015 - 2018 口腔癌の薬剤耐性関連エクソソームmicroRNAの同定と診断と治療への応用
- 2014 - 2017 The detrimental effect of soluble IL-6 receptor on CD4 T cell-mediated anti-tumor immune responses
- 2014 - 2016 The investigation of the role of fibronectin on the mechanisms underlying 5-FU resistance in oral squamous cell carcinoma
- 2014 - 2016 Functional analysis of oral cancer stem cell-related microRNAs and development of novel therapies
- 2013 - 2016 Development of treatment planning system for neck node metastases
- 2012 - 2015 Clinical study of multiple peptide vaccination for postoperative oral cancer patients revealed induction of immune responses and improved prognosis.
- 2012 - 2014 Investigation of the function of nucleostemin in oral squamous cell carcinoma and develop the new therapeutic approoach
- 2011 - 2014 マイクロRNA解析による口腔癌の薬剤耐性化機構の解明と新規診断治療法への応用
- 2014 - 口腔扁平上皮癌の放射線耐性と悪性形質獲得機構に関する研究
- 2012 - 2013 Clinical trial of adjuvant peptide vaccine therapy for oral cancer研究代表者
- 2009 - 2011 口腔癌のゲノム異常解析を用いた5-FU耐性化機構の解明と集学的個別化治療への応用
- 2009 - 2011 The identification of the oral cancer stem cell and analysis of the property-Role analysis of the epigenetic regulation and application to treatment-
- 2009 - 2010 口腔癌の新規腫瘍拒絶抗原を標的としたペプチドワクチン療法の確立
- 2007 - 2008 Epigenetic investigation of oral squamous cell carcinoma -Application of epigenetic changes to cancer diagnosis and treatment-
- 2005 - 2006 Genome research on interindividual variations on Invasive potenncial and application of genetic diagnosis to personalized medicine
- 2006 - 歯周病と急性冠症候群の関連についての研究
- 2006 - Study on association between periodontitis and acute coronary syndrome
- 2004 - 口腔扁平上皮癌の抗癌剤耐性化機構に関する研究
- 2004 - Study on the mechanism of chemoresistance in oral squamous cell carcinoma
- 2002 - 口腔扁平上皮癌の浸潤・転移における転写因子NF-kBの役割に関する研究
- 2002 - Study on the role of transcription factor NF-kB in invasion and metstasis of oral squamous cell carcinoma
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Papers (141):
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Ryo Toya, Yoshiyuki Fukugawa, Tetsuo Saito, Tomohiko Matsuyama, Ryoji Yoshida, Daizo Murakami, Yorihisa Orita, Hideki Nakayama, Natsuo Oya. Radiation Therapy Oncology Group 8502 "QUAD shot" regimen using volumetric modulated arc therapy for incurable head and neck cancer. Oral oncology. 2024. 151. 106752-106752
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Kohei Ishikawa, Yuichiro Matsuoka, Kosuke Shinohara, Junki Inoue, Hiromu Yano, Takafumi Eto, Tatsuro Yamamoto, Keisuke Yamana, Shunsuke Gohara, Hisashi Takeshita, et al. Involvement of ferroptosis-defensive xCT/GPX4 axis in radioresistance and its impacts on prognosis in oral squamous cell carcinoma. Oral Science International. 2024
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Yuki Seki, Keisuke Yamana, Ryoji Yoshida, Junki Inoue, Kosuke Shinohara, Toru Oyama, Ryuta Kubo, Masashi Nagata, Kenta Kawahara, Masatoshi Hirayama, et al. Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2024
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Manami Suzuki-Karasaki, Yushi Ochiai, Shizuka Innami, Hiroshi Okajima, Miki Suzuki-Karasaki, Hideki Nakayama, Yoshihiro Suzuki-Karasaki. Ozone mediates the anticancer effect of air plasma by triggering oxidative cell death caused by H2O2 and iron. European journal of cell biology. 2023. 102. 4. 151346-151346
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Nobuhiro Yamakawa, Hiroyuki Harada, Hideki Nakayama, Yoichi Ohiro, Hiroki Bukawa, Tadaaki Kirita. Preoperative chemoradiotherapy for locally advanced oral squamous cell carcinoma: A multicenter retrospective study. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023
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MISC (274):
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本田実琴, 廣末晃之, 平山真敏, 高橋望, 川原健太, 永田将士, 吉田遼司, 中山秀樹, 廣末晃之, 平山真敏, et al. 口腔外科疾患術後にインプラントによる咬合再建を施行した患者の口腔衛生管理における現状と課題. 日本口腔ケア学会雑誌. 2022. 16. 3
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岡林比呂子, 増永愛子, 一安秀範, 吉田遼司, 中山秀樹, 伊勢桃子, 宮本裕士, 坂上拓郎. Risk factors and prognosis of cetuximab induced interstitial lung disease. 日本呼吸器学会誌(Web). 2022. 11
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諸富静香, 高橋望, 川原健太, 平山真敏, 永田将士, 廣末晃之, 吉田遼司, 中山秀樹. Clinical study of metastatic tumors to the jaws and oral cavity in our department. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2022. 40th
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吉田遼司, 坂田純基, 井上淳貴, 川原健太, 平山真敏, 高橋望, 永田将士, 廣末晃之, 中山秀樹. Reconsidering elective neck dissection from a retrospective analysis of clinical N0 oral squamous cell carcinoma. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2022. 40th
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吉田遼司, 郷原俊輔, 川原健太, 平山真敏, 高橋望, 廣末晃之, 永田将士, 中山秀樹. Development of radiation therapy with oncolytic virus to further Improve treatment outcome of oral cancer. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2022. 40th
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Books (11):
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口腔癌診療ガイドライン 2023年版 口腔癌診療ガイドライン改訂合同委員会編
金原出版 2023 ISBN:9784307450157
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口腔癌 = Oral cancer
医歯薬出版 2023
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口腔外科研修ハンドブック
医歯薬出版 2022 ISBN:9784263458914
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一般臨床家, 口腔外科医のための口腔外科ハンドマニュアル : 口腔外科YEAR BOOK
クインテッセンス出版 2022 ISBN:9784781208855
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口腔外科学 第4版
医歯薬出版 2020 ISBN:9784263458433
more...
Lectures and oral presentations (56):
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下顎歯肉癌に対し下顎辺縁切除術と分層植皮術を同時に行った症例
(第36回日本口腔腫瘍学会学術大会 ビデオセッション2 下顎辺縁切除術 2018)
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年齢や全身状態を踏まえた口腔癌手術について-有茎皮弁再建を中心に-
(第35回日本口腔腫瘍学会 学術セミナー2 2017)
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近況報告と今後の抱負について
(2016)
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視点を変えれば見方が変わる! 顎口腔領域の異常の捉え方について
(平成27年度 特定非営利活動法人 日本歯周病学会 第7回九州地区臨床研修会 教育講演2 2016)
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IL-6 confers radioresistance via Nrf2 antioxidant pathway in oral squamous cell carcinoma cells
(The 63rd Annual Meeting of Japanese Association for Dental Research 2015)
more...
Works (3):
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術前放射線治療30Gy後の唾液分泌量回復と口腔乾燥症状の改善効果に関する研究
2011 - 2012
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歯周病治療による重症狭心症および急性心筋梗塞発症予防へ向けた新たな治療戦略
2007 - 2008
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ゲノム遺伝子解析による癌の個性診断と分子標的治療への応用
2005 - 2007
Education (4):
- - 2002 Kyushu University
- - 2002 Kyushu University Graduate School, Division of Dental Research
- - 1996 Kyushu University School of Dentistry
- - 1996 Kyushu University Faculty of Dentistry
Professional career (1):
- Doctor of Dentistry (Kyushu University)
Work history (24):
- 2019/04 - 現在 Kumamoto University Faculty of Life Sciences
- 2018/04 - 現在 九州大学 非常勤講師
- 2019/04 - 2021/03 Kumamoto University
- 2019/04 - 2021/03 Kumamoto University
- 2017/04 - 2019/03 Kumamoto University University Hospital
- 2016/10 - 2019/03 Kumamoto University University Hospital
- 2015/04 - 2019/03 Kumamoto University University Hospital
- 2015/01 - 2019/03 Kumamoto University Faculty of Life Sciences
- 2015/04 - 2017/03 Kumamoto University University Hospital
- 2013/04 - 2015/03 Kumamoto University University Hospital
- 2015 - Professor, ,Faculty of Life Sciences(Clinical medicine group),Kumamoto University
- 2013 - 2014 熊本大学医学部附属病院歯科口腔外科 講師
- 2013 - 2014 Lecturer, ,University Hospital ,Kumamoto University
- 2012/04 - 2013/03 Kumamoto University University Hospital
- 2012 - 2013 Kumamoto University Faculty of Life Sciences
- 2012 - 2013 Assistant Professor, ,Faculty of Life Sciences(Clinical medicine group),Kumamoto University
- 2009/04 - 2012/03 Kumamoto University University Hospital
- 2007 - 2012 助教
- 2007 - 2012 Assistant Professor,
- 2007/04 - 2009/03 Kumamoto University University Hospital
- 2005/11 - 2007/03 Kumamoto University University Hospital
- 2004 - 2007 助手
- 2004 - 2007 Research Associate,
- 1998 - 2002 九州大学 大学院
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Committee career (4):
- 2018 - 現在 日本頭頸部癌学会 代議員
- 2015 - 現在 日本口腔科学会 評議員
- 2014 - 現在 日本口腔腫瘍学会 評議員
- 2014 - 現在 日本口腔外科学会 代議員
Awards (2):
- 2010 - Most Valuable Poster Presentation Award of The 51th Congress of the Korean Association of Oral and Maxillofacial Surgeons
- 2008 - Outstanding Poster Award
Association Membership(s) (15):
日本有病者歯科医療学会
, 日本口腔内科学会
, 日本放射線影響学会
, 日本顎関節学会
, 日本顎変形症学会
, 日本口腔腫瘍学会
, 日本口腔顎顔面外傷学会
, 日本頭頸部癌学会
, アジア口腔顎顔面外科学会
, Japan Society of Clinical Oncology
, 日本顎顔面インプラント学会
, 日本口腔科学会
, 日本癌学会
, 日本口腔外科学会
, 日本口腔ケア学会
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