Toshihisa Komori

2020 - 2022 Elucidation of the molecular mechanism of transdifferentiation of chondrocytes into osteoblasts and the origin of bone marrow osteoblasts

2017 - 2022 Gene activated-matrix comprised of self-assemble and multi-functional nano-devise facilitates the bone engineering

2017 - 2020 Elucidation of the function of Supt3 in skeletal formation and its interaction with Runx2 promoter.

2018 - 2020 Elucidation of the mechanism of the regulation of Col1a1 gene expression by Runx2

2015 - 2018 Studies for expression and function of Runx2 isoforms

2015 - 2018 Analysis of the function of microtubule-associated protein tau (Mapt) and nestin in the formation of odontoblast processes using the genetically modified mice

2015 - 2018 A study of increase bone volume using transgenic mice with osteoblasts that express proliferation and anti-apoptotic factors

2016 - 2018 Identification of the target genes of glucocorticoid receptor in the pathogenesis of steroid-induced osteoporosis

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2015 - 2017 Basic research on technology development of tooth regeneration with regard to transcription factor Cebpb and Runx2

2015 - 2017 Analysis on the supply system of phosphate ions by osteoblasts/osteocytes during bone mineralization

2014 - 2017 The roles of vitamin D dependent novel phosphate sensing-system on calcium metabolism and local calcification.

2013 - 2017 Bone engineering with gene activated-matrix and non-cultured adipose cells

2014 - 2017 Elucidation of the transcriptional regulation of Runx2 and development of the drugs for osteoporosis and osteoarthritis

2014 - 2016 Elucidation of the pathogenesis of disuse osteoporosis and steroid-induced osteoporosis using Fkbp5 knockout mice

2014 - 2015 Runx2遺伝子の軟骨細胞特異的エンハンサーの同定とその制御機構の解明

2012 - 2015 A study of mechanical stress response genes via osteocyte network

2012 - 2015 Molecular morphological examination about the formation of processes in the osteoblasts and odontoblasts

2012 - 2014 Investigation into the mechanism in the development of disorder of masticatory and swallowing centers using time and brain-specific conditional knockout mice

2012 - 2014 Identification and functional analysis of a novel substrate of Pdk4 in the regulation of osteoclastogenesis in the unloaded condition

2010 - 2014 The mechanism of transcriptional regulation of Runx2 gene and the program of skeletal development

2010 - 2012 Functional analysis of a mechanical stress responsible geneFbxo32 on bone volume regulation

2010 - 2012 Jaw bone regeneration using gene activated matrix incorporated withdirectly prepared adipose derived stem cells

2010 - 2012 Alveolar bone engineering using alveolar bone marrow derived mesenchymal stem cells

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2010 - 2011 Grant-in-Aid for Challenging Exploratory Research

2009 - 2011 The regulation of bone formation by epigenetic factor MeCP2

2009 - 2011 Histological examination about the role of Runx2 in tertiary dentin formation

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2007 - 2008 骨芽細胞における核小体型副甲状腺ホルモン関連ペプチドの新規作用

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2004 - 2005 細胞周期関連分子CDK6の生体内における骨・軟骨代謝調節機構の解明

2004 - 2005 Molecular and cell biological approach to promote the eruption of impacted teeth

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2003 - 2004 Functional Analysis of Dentin Matrix Protein 1 (DMP1) and Regulation Analysis of their Expression during Fracture Healing.

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2002 - 2004 Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development : comparison of MR imaging and histological findings

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2002 - 2003 細胞周期関連分子CDK6による骨・軟骨細胞分化制御機構に関する基礎的研究

2002 - 2003 トランスジェニックマウスを用いた新規遺伝子CORS26の頭蓋顔面形成機能の解析

2002 - 2003 Basic research to clarify the mechanism of delayed tooth eruption in cleidocranial dysplasia

2001 - 2002 Functional analysis of osteocyte-specific acidic phosphoprotein by gene transfection

2001 - 2002 Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals

2000 - 2002 Molecular pathological study of tooth germ and odonto genic tumor

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2000 - 2000 トランスジェニックマウスを用いたCbfa1の組織別機能解析

1999 - 1999 転写因子Cbfa1を中心とした硬組織形成過程に関わる遺伝子群の解明

1997 - 1997 コンディショナル遺伝子破壊による発がん機構の解析

1997 - 1997 AML1遺伝子による初期造血幹細胞の分化制御機構の解析

1995 - 1995 ジーンターゲティングによるCD34分子の機能解析

1995 - 1995 胎生期レパトアの機能解析と自己免疫疾患に及ぼすN領域の影響

1995 - 1995 TdTによるT細胞・B細胞レセプターの多様性変化とその免疫応答に及ぼす影響

1994 - 1994 PML、tie欠失マウスの作製と血球の発生・分化との関わり

1994 - 1994 種々のTdTの発現パターンに伴うT細胞・B細胞レパトアと自己免疫疾患マウスの誘導

1987 - 1988 Analysis of the mechanisms of V_H gene selection in theformation of immunoglovulin heavy chain variable region genes.