Rchr

J-GLOBAL ID：200901044934610046 Update date: Apr. 17, 2024

Watanabe Sumiko

Affiliation and department：
Job title： Professor
Other affiliations (1)：

韓国順天卿大学客員教授

Homepage URL (1)： http://www.ims.u-tokyo.ac.jp/moldev/

Research field (3)： Developmental biology , Cell biology , Molecular biology

Research keywords (6)：発生生物学 , 細胞生物学 , 分子生物学 , Developmental Biology , Cell Biology , Molecular Biology

Research theme for competitive and other funds (52)：

2021 - 2024 視細胞変性のオンセットと進展制御に関わる網膜内炎症環境の時空的な解析
2017 - 2019 Analysis of retinoblastoma using human iPS cells
2017 - 2019 Regulation of mouse and human retinal differentiation by histone methylation
2015 - 2018 Roles of HIston methyation in retinal defferentiation and maintenance
2015 - 2017 A challenge to induce retinal regeneration by gene transfection

2015 - 2017 Analysis of molecular basis of retinal glial cells and their roles in retinal degeneration diseases

2013 - 2015 哺乳動物網膜をモデル系としたエピジェネティックな制御による細胞運命決定機構の研究

2013 - 2015 Analysis of expression of Cd antigens in retinoblastoma, and its application for disease classification and therapeutic strategy

2011 - 2013 哺乳動物網膜をモデル系とした神経・グリア分化制御分子基盤の解明

2011 - 2012 Establish of iPS by expression of microRNA

2009 - 2010 がん細胞からiPS細胞を介し樹状細胞を誘導し、がん免疫療法に利用する試み

2008 - 2009 網膜芽細胞腫の細胞系譜・分子基盤の解明とその増殖機構の破綻メカニズムの解析

2006 - 2007 Wntによる網膜分化・増殖タイミングの時空的制御とその破綻によるがん化機構の解析

2005 - 2006 Identification of mouse retinal stem cell and cell lineages by gene expression patterns

2004 - 2006 歯の再生過程からの幹細胞の分離、同定およびその幹細胞による歯の再生

2004 - 2005 水晶体発生過程をモデル系とした細胞増殖、分化制御機構の研究

2003 - 2004 Identification and purification of retinal stem cells by the expression pattern of specific genes.

2002 - 2002 水晶体発生過程をモデル系とした器官発生における細胞増殖、分化制御機構の研究

2002 - 2002 ゼブラフィッシュの挿入変異生成法による脊椎動物遺伝子の機能解析

2001 - 2002 Analysis of roles of GM-CSF for proliferation and differentiation of NKT cells

2001 - 2002 Analysis of the function of lymphocyte adhesion molecules and its clinical significances in autoimmune diseases

2001 - 2001 水晶体発生過程をモデル系とした器官発生における細胞増殖、分化制御機構の研究

2001 - 2001 STAT5の細胞質・核輸送機構の研究

1999 - 2001 Drug discovery and design based on molecular mimicry

2000 - 2000 二量体化ライブラリーを用いた増殖・抗アポプトーシス関連遺伝子の単離

2000 - 2000 サイトカインによるSTATの核・細胞質輸送機構制御の研究

1999 - 2000 Joint study on DNA replication and checkpoint control

1999 - 2000 Molecular Mimicry in Translation

1999 - 2000 Analysis of CD29/VLA integrin in T cell immune regulation and its clinical significance

1998 - 1999 Analysis of cell proliferation by GM-CSF

1998 - 1999 Studies of differentiation mechanisms of hematopoietic stem cells using cytokine-receptor transgenic mice

1998 - 1998 サイトカインレセプターとその変異体遺伝子導入マウス作製とその血液学的解析

1998 - 1998 変異ヒトG-CSFレセプタートランスジェニックマウスを用いた白血病発症機構の研究

1997 - 1998 Cloning of Molecules Supporting Self-renewal of Hematopoietic Stem Cells

1997 - 1998 Joint study on activation of eukaryotic replication origins

1996 - 1998 Analyses of cytokine gene expression by helper T cell subsets : role of NFAT-mediated gene activation and subset-specific regulatory mechanism.

1997 - 1997 ヒトG-CSFレセプタートランスジェニックマウスを用いた白血病発症機構の研究

1996 - 1997 Regulation of Cell proliferation by GM-CSF

1995 - 1997 Generation of disease model mice by the alteration of transcription factors regulating immune responses

1995 - 1997 Production of erythrocytes, granulocytes and megakaryocytes by gp130 signalling and related molecular mechanisms.

1995 - 1997 Joint study on regulation of cell profferation by cytokines

1996 - 1996 hGM-CSFレセプタートランスジェニックマウスを用いたリンパ球分化の解析

1994 - 1996 Study of mechanism of action of cytokines and signaling molecules using adenoviral transient expression vectors

1992 - 1994 Regulation of IL-3 and GM-CSF genes and their receptors

1993 - 1993 IL-3 およびGM-CSFレセプターシグナルによるDNA複製制御機構の研究

1993 - 1993 サイトカインによる細胞の増殖,分化の制御とシグナル伝達

1992 - 1992 サイトカインによる細胞の増殖.分化の制御とシグナル伝達

網膜再生発生、幹細胞分化制御、サイトカインレセプターシグナル

網膜発生と再生の研究

サイトカインレセプターシグナル伝達とその幹細胞増幅への応用

Development and regeneration of retina

Signal transduction of Cytokine receptor and expansion of Hematopoietie stem cell.

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Papers (123)：

Toshiro Iwagawa, Masaya Fukushima, Shigeru Takeuchi, Yuichi Kawamura, Yuko Aihara, Manabu Ozawa, Nayuta Yakushiji-Kaminatsui, Makoto Aihara, Haruhiko Koseki, Yutaka Suzuki, et al. The histone H3K36 demethylase Fbxl11 plays pivotal roles in the development of retinal late-born cell types. Genes to cells : devoted to molecular & cellular mechanisms. 2023
Katsuyuki Nagata, Daisuke Hishikawa, Hiroshi Sagara, Masamichi Saito, Sumiko Watanabe, Takao Shimizu, Hideo Shindou. Lysophosphatidylcholine acyltransferase 1 controls mitochondrial reactive oxygen species generation and survival of retinal photoreceptor cells. Journal of Biological Chemistry. 2022. 298. 6. 101958-101958
Fumie Hamano, Hiroshi Kuribayashi, Toshiro Iwagawa, Asano Tsuhako, Katsuyuki Nagata, Hiroshi Sagara, Takao Shimizu, Hideo Shindou, Sumiko Watanabe. Mapping membrane lipids in the developing and adult mouse retina under physiological and pathological conditions using mass spectrometry. Journal of Biological Chemistry. 2021. 296. 100303-100303
Yuta Moriuchi, Toshiro Iwagawa, Asano Tsuhako, Hideto Koso, Yasuyuki Fujita, Sumiko Watanabe. RasV12 Expression in Microglia Initiates Retinal Inflammation and Induces Photoreceptor Degeneration. Investigative Opthalmology & Visual Science. 2020. 61. 13. 34-34
Daisy Umutoni, Toshiro Iwagawa, Yukihiro Baba, Asano Tsuhako, Hiroaki Honda, Makoto Aihara, Sumiko Watanabe. H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina. Genes to Cells. 2020. 25. 6. 402-412

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MISC (34)：

菱川大介, 進藤英雄, 高祖秀登, 佐々木順子, 中西弘樹, 佐々木雄彦, 渡辺すみ子, 清水孝雄. 網膜視覚科学の最前線網膜視細胞における膜リン脂質組成の意義. 生命科学系学会合同年次大会. 2017. 2017年度. [3PW06-3]
Akira Murakami, Yuki Yoshikawa, Sumiko Watanabe. The roles of nicotinamide nucleotide adenylyltransferase 1 gene in developing mouse retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12
Sumiko Watanabe, Hideto Koso. Identification of microglia specific genes using a new mouse model of rod photoreceptor degeneration. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016. 57. 12
Sumiko Watanabe, Toshiro Iwagawa, Akira Murakami. Roles of Histone H3K27 tri-methylation for maintenance of rod photoreceptors. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2015. 56. 7
Akira Murakami, Toshiro Iwagwa, Sumiko Watanabe. Roles of HistoneH3K27 tri-methylation for differentiation of subsets of retinal cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2015. 56. 7

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Professional career (1)：

(BLANK)

Association Membership(s) (4)：

国際サイトカインインターフェロン学会 , 日本免疫学会 , 日本がん学会 , 日本生化学会

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