Rchr
J-GLOBAL ID:200901045235116776
Update date: Feb. 01, 2024
Tachibana Makoto
タチバナ マコト | Tachibana Makoto
Affiliation and department:
Job title:
Associate Professor,Associate Professor
Homepage URL (1):
http://www.fbs.osaka-u.ac.jp/labs/tachibana/
Research field (1):
Genomics
Research keywords (6):
転写制御
, クロマチン
, 生殖
, 発生
, エピジェネティクス
, 遺伝
Research theme for competitive and other funds (26):
- 2022 - 2024 全能性関連遺伝子の発現におけるエピゲノムと転写因子の貢献度の解明
- 2021 - 2024 ほ乳類性決定遺伝子Sryの作用機序とそのゲノム進化過程の抜本的な見直し
- 2022 - 2023 「性スぺクトラム」研究のとりまとめ
- 2021 - 2023 鉄によるエピゲノム制御 -母体の鉄量変動は胎仔のエピゲノムを変えるのか?-
- 2017 - 2022 性スペクトラム研究の運営
- 2017 - 2022 Sex spectrum of embryonic gonads
- 2017 - 2022 Spectrum of the Sex: a continuity of phenotypes between female and male
- 2019 - 2021 Evolution of mammalian sex-determining system by insertion of transposons
- 2018 - 2021 Study of H3K9me reader of mammalian sex-determining gene Sry
- 2016 - 2018 H3K9脱メチル化エピゲノムによる生殖細胞の機能制御
- 2016 - 2018 胚性幹細胞の機能を支えるH3K9me2染色体構造
- 2016 - 2018 Studies on novel epigenetic regulator of the sex-determine in mammal
- 2014 - 2017 Molecular mechanism of epigenetic regulation of mammalian sex differentiation
- 2014 - 2016 H3K9脱メチル化エピゲノムによる生殖細胞の機能制御
- 2014 - 2015 Analysis of target genes of the sex-determining gene, Sry
- 2009 - 2012 Histone demethylase Jmjd1a as a regulator of glycolipid metabolism
- 2008 - 2012 Regulation and roles of histone methylation dynamics in germ-lineage cells
- 2009 - 2011 ヒストンメチル化のダイナミクスと生体機能
- 2009 - 2009 ヒストンの脱メチル化による性決定の分子メカニズム
- 2008 - 2009 ヒストンメチル化酵素複合体による転写抑制機構の分子基盤
- 2007 - 2008 Study of histone demethylation for mammalian development and differentiation
- 2006 - 2007 ヒストンのメチル化による生殖細胞分化制御機構
- 2006 - 2007 ヒストンメチル化酵素複合体による転写制御
- 2005 - 2005 試験管内再構築系による、コアヒストンのリジンのメチル化と転写との関連評価
- 2001 - 2005 Molecular Mechanism for cellular senescence and immortalization
- 2000 - 2000 哺乳類テロメア維持の新たな分子機構の解析
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Papers (103):
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Naoki Okashita, Ryo Maeda, Makoto Tachibana. CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 20. e2221499120
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Shingo Miyawaki, Makoto Tachibana. The Evolutionary Aspects of the Mammalian Sex-Determining Gene SRY. Spectrum of Sex. 2022. 69-84
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Ryo Maeda, Makoto Tachibana. HP1 maintains protein stability of H3K9 methyltransferases and demethylases. EMBO reports. 2022. 23. 4. e53581
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Naoki Okashita, Makoto Tachibana. Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene SRY. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 2021. 1-9
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Takashi Yoshino, Takahiro Suzuki, Go Nagamatsu, Haruka Yabukami, Mika Ikegaya, Mami Kishima, Haruka Kita, Takuya Imamura, Kinichi Nakashima, Ryuichi Nishinakamura, et al. Generation of ovarian follicles from mouse pluripotent stem cells. Science. 2021. 373. 6552. eabe0237-eabe0237
more...
MISC (5):
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K Ikegami, M Tachibana, M Iwatani, N Hattori, S Tanaka, Y Shinkai, K Shiota. Null mutation of histone H3-K9 methyltransferase G9a links to genome-wide DNA demethylation at gene coding regions in euchromatin. FASEB JOURNAL. 2004. 18. 8. C285-C285
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M Tachibana, O Narumi, K Muguruma, Yamamoto, I, Y Shinkai, Y Yokota. Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23). CYTOGENETICS AND CELL GENETICS. 2001. 94. 1-2. 23-25
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M. Senoo, N. H. Seki, M. Ohira, S. Sugano, M. Watanabe, M. Tachibana, T. Tanaka, Y. Shinkai, H. Kato. Erratum: A second p53-related protein, p73L, with high homology to p73 (Biochemical and Biophysical Research Communications (1998) 248, 3 (603-607)). Biochemical and Biophysical Research Communications. 1998. 250. 536
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M Senoo, N Seki, M Ohira, S Sugano, M Watanabe, M Tachibana, T Tanaka, Y Shinkai, H Kato. A second p53-related protein, p73L, with high homology to p73 (vol 248, pg 603, 1998). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998. 250. 2. 536-536
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M Senoo, N Seki, M Ohira, S Sugano, M Watanabe, M Tachibana, T Tanaka, Y Shinkai, H Kato. A second p53-related protein, p73L, with high homology to p73. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998. 248. 3. 603-607
Education (2):
- 1990 - 1995 The University of Tokyo Graduate School of Agricultural and Life Sciences
- 1986 - 1990 The University of Tokyo
Professional career (1):
Work history (8):
- 2018/10 - 現在 Osaka University Graduate School of Frontier Biosciences
- 2016/04 - 2018/09 The University of Tokushima
- 2013/12 - 2015/03 The University of Tokushima The Institute for Enzyme Research
- 2005/09 - 2013/12 Kyoto University Institute for Virus Research
- 2009/10 - 2013/03 科学技術振興機構さきがけ「エピジェネティクスの制御と生命機能」 研究者
- 1998/09 - 2005/08 Kyoto University Institute for Virus Research
- 1997/05 - 1998/05 株式会社日本ロシュ研究所 研究員
- 1995/04 - 1996/04 株式会社三菱化学生命科学研究所 ポスドク
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Association Membership(s) (2):
日本エピジェネティクス研究会
, 日本分子生物学会
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