Rchr

J-GLOBAL ID：200901045561305856 Update date: Apr. 17, 2024

Iwata Hisato

イワタヒサト | Iwata Hisato

Affiliation and department：
Job title： Professor,Faculty of Agriculture, Professor
Other affiliations (1)：

愛媛大学理学部・理工学研究科(兼務) 教授

Homepage URL (2)： http://ecotoxiwata.jp/ , http://ecotoxiwata.jp/en/

Research field (7)： Landscape science , Environmental agriculture , Biological resource conservation , Environmental effects of chemicals , Environmental effects of radiation , Environmental policy and society , Environmental impact assessment

Research keywords (19)： bioinformatics , interspecies difference , sensitivity , intracellular receptor , omics , 水圏環境保全学 , エコトキシコゲノミクス , 生物遺伝子資源保全 , 環境化学 , 環境毒性学 , リスク評価 , 環境汚染 , 環境分析 , 生態系影響評価 , Ecotoxicogenomics and Proteomics , Conservation of Genomic Resources , Envirommental Toxicology , Environmental Analysis and Environmental Contamination , Environmental Risk Assessment

Research theme for competitive and other funds (43)：

2023 - 2027 Spatiotemporal trend analysis and ecological risk assessment of monitoring and emerging environmental chemicals in the Asia-Pacific region
2022 - 2025 Establishment of cetacean iPS cells and application to neurotoxicity assays of environmental pollutants
2021 - 2025 メキシコ産ワニを対象とした次世代型モニタリング基盤の開発
2020 - 2024 Development of risk assessment method and present of brain transfer by ionic environmental contaminants using fish as an indicator
2019 - 2024 化学物質による水棲哺乳類細胞内受容体シグナル撹乱と感受性を規定する分子機構の解明

2019 - 2022 Biomagnification mechanism, spatiotemporal trend, and risk assessment of legacy and new environmental pollutants in various aquatic animal species

2019 - 2021 Development of a novel method for evaluating avian embryonic toxicity by continuous observation using a shell-less incubation system

2017 - 2019 Effects of environmental pollution and stress on gene expression profiles in Baltic salmons

2016 - 2019 Elucidation of widespread contamination status and bioaccumulation features of emerging persistent organic pollutants and assessment of their ecological effects

2014 - 2019 Multiple Omics Analysis to Understand the Species Differences in Chemical-intracellular Receptor Signaling Disruption

2015 - 2018 Establishment for long-term risk assessment system of oil spill and severe PAH pollution caused by large-scale disasters

2013 - 2016 Chemical hazard assessment with the genome-nuclear receptor interaction array system

2013 - 2016 Contamination status of organohalogen compounds and their metabolites of pet animals and effects on thyroid hormones homeostasis

2009 - 2014 Clarification of factors governing sensitivity of disruption of intracellular receptor-xenobiotic metabolizing enzyme signaling pathways by chemical substances

2008 - 2012 Environmental Contamination and Ecological Risk of Novel POPs in the Asian Developing Region

2009 - 2011 Large-scale differential display system with vertebrate-common degenerate oligonucleotide primers

2006 - 2008 Specific accumulation, metabolism and potential effects of persistent organohalogen compounds in predatory wild animals

2006 - 2008 野生鳥類のメタロチオネインを利用した重金属汚染のリスク評価に関する研究

2005 - 2008 High-throughput risk assay of chemicals using a nuclear receptor, CAR from aquatic animals

2006 - 2007 Risk assessment of chemicals using avian AHR isoforms

2004 - 2007 Studies on the Contamination Status, Bioaccumulation and Risk Assessment of PBDE, Brominated Flame Retardant, in the Environment

2005 - 2006 野生カワウ個体群のエコトキシコゲノミクス

2003 - 2006 メコンデルタにおける水資源の汚染実態と高次生物ならびにヒトに対する毒性影響に関する研究

2003 - 2006 Chemical Contamination in Mekong Delta and Their Toxic Effects on Higher Trophic Animals and Human

2002 - 2006 野生生物のエコトキシコゲノミクス・プロテオミクス

2002 - 2006 化学物質汚染による生態系への影響

2002 - 2006 Ecotoxicogenomics and proteomics in wildlife

2002 - 2006 Toxic impacts of environmental contaminants in ecosystem

2001 - 2004 毒性影響の種特異的感受性を決定する生体分子機構の解明

2001 - 2004 Understanding of molecular mechanisms responsible for species-specific sensitivity of chemical toxicity

2001 - 2004 Development of method for assessing species-specific risk of Ah receptor-mediated dioxin toxicity

2001 - 2003 野生生物における内分泌攪乱物質の汚染とそのリスク評価

2000 - 2003 Studies on the Environmental Chemistry for the Contamination and Toxic Effects of Bioaccumulative Endocrine Disrupters in Higher Wildlife

1997 - 2000 Development of assessment method for complex aquatic pollution using xenobiotic metabolic enzyme in liver of aquatic mammals

2000 - 化学物質のリスクを評価するためのバイオアッセイ法の開発

1997 - 1999 水棲哺乳動物における複合汚染状況を考慮した生体毒性学的研究 -環境汚染物質の生体内相互作用-

1997 - 1999 MUSSEL WATCH : MARINE POLLUTION MONITORING IN ASIAN WATERS

1997 - 1998 癌予防を目指す関連チトクロムP450の検出フォトダイナミック診断法の基礎研究

1996 - 1998 DEVELOPMENT OF CYTOCHROME P-450 PROCESS FOR THE STUDY OF TOXICOLOGY WITHOUT USING ANIMALS

1997 - 1997 環境中ダイオキシンによる免疫抑制機構の解明

1995 - 1997 Establishment of model animals for polymorphic drug metabolism associated with CYP2D

難分解性有機塩素化合物の地球規模での分布・動態・ゆくえ

Global distribution,dynamics and fate of persistent organochlorines

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Papers (230)：

Hao Chen, Kaori Chigusa, Kazuki Kanda, Rumi Tanoue, Mari Ochiai, Hisato Iwata. Developmental toxicity of short-chain chlorinated paraffins on early-stage chicken embryos in a shell-less (ex-ovo) incubation system. Ecotoxicology and Environmental Safety. 2024. 276. 116304-116304
Kazuki Kanda, Hisato Iwata. Tris(2-chloroethyl) phosphate (TCEP) exposure inhibits the epithelial-mesenchymal transition (EMT), mesoderm differentiation, and cardiovascular development in early chicken embryos. Science of The Total Environment. 2024. 922. 171242-171242
Hoa Thanh Nguyen, Yuka Yoshinouchi, Masashi Hirano, Kei Nomiyama, Haruhiko Nakata, Eun-Young Kim, Hisato Iwata. In silico simulations and molecular descriptors to predict in vitro transactivation potencies of Baikal seal estrogen receptors by environmental contaminants. Ecotoxicology and Environmental Safety. 2023. 265. 115495-115495
Kaori Chigusa, Kazuki Kanda, Hisato Iwata. Developmental toxicity in early chicken embryos on exposure to an organophosphorus flame retardant, tris(2-chloroisopropyl) phosphate. Ecotoxicology and environmental safety. 2023. 264. 115445-115445
Akira Kubota, Masashi Hirano, Yuka Yoshinouchi, Xing Chen, Michiko Nakamura, Yumi Wakayama, Jae Seung Lee, Haruhiko Nakata, Hisato Iwata, Yusuke K. Kawai. In vivo and in silico assessments of estrogenic potencies of bisphenol A and its analogs in zebrafish (Danio rerio): Validity of in silico approaches to predict in vivo effects. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2023. 269. 109619-109619

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MISC (214)：

平川周作, 堀就英, 香月進, 宮脇崇, 平野将司, 岩田久人, 辻学. Characteristics of dioxins accumulated in Yusho patients and estimation of cytochrome P450-dependent metabolism by in silico docking simulation. 環境化学討論会要旨集(CD-ROM). 2022. 30th
平川周作, 宮脇崇, 堀就英, 香月進, 平野将司, 岩田久人, 辻学. Analysis of factors affecting the characteristic accumulation patterns of PCB congeners in Yusho patients. 環境化学討論会要旨集(CD-ROM). 2021. 29th
水川葉月, NGYUEN Hoa Thanh, 岩田久人, 野見山桂, 池中良徳, 中山翔太, 横山望, 市居修, 滝口満喜, KHIDKHAN Kraisiri, et al. PCBs曝露によるネコ肝トランスクリプトームへの影響. 環境化学討論会要旨集(CD-ROM). 2019. 28th. ROMBUNNO.1C-08
Hirakawa S, Miyawaki T, Hori T, Kajiwara J, Katsuki S, Hirano M, Yoshinouchi Y, Iwata H, Mitoma C, Furue M. IN SILICO PREDICTION OF THE METABOLISM OF PCB CONGENERS BY CYTOCHROME P450 ISOZYMES IN YUSHO PATIENTS. Organohalogen compounds. 2019. 81. 171-174
石橋弘志, 石橋弘志, 平野将司, 内田雅也, 大倉美咲, 石橋康弘, 冨永伸明, 岩田久人, 有薗幸司. 新たな試験法の切り口:内分泌かく乱物質-核内受容体相互作用のin silico解析. 日本内分泌かく乱化学物質学会研究発表会要旨集. 2018. 21回. 39-39

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Books (37)：

「環境ホルモンによる海洋汚染とクジラ・アザラシ・ホッキョクグマへの影響」海とヒトの関係学4 疫病と海(秋道智彌・角南篤編)
西日本出版社 2021 ISBN:9784908443596
生物の科学遺伝~死体に学ぶクジラ・イルカの秘密~
株式会社エヌ・ティー・エス 2019
環境毒性学: 環境毒性学の未来
朝倉書店 2011
環境毒性学: バイオマーカー
朝倉書店 2011
Arsenic in Geosphere and Human Diseases : Methylation of inorganic arsenic and genetic polymorphisms in arsenic (+III oxidation state) methyltransferase in a Vietnamese population
CRC Press 2010

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Lectures and oral presentations (276)：

Effects on the cardiovascular system of ex ovo chicken embryos exposed to tris (2-chloroethyl) phosphate (TCEP)
(International Symposium on Research Collaboration: Usable Science Resulting in Impact 2021)
In vitro and in silico assessment of the activation of chicken estrogen receptor α by bisphenol analogs
(2021)
Effects of organohalogen compounds and temperature on the liver transcriptome and proteome of Baltic salmon
(4th International Chemical Hazard Symposium 2021)
Multi omics analyses revealed varying susceptibilities of rat offspring to prenatal bisphenol A exposure
(4th International Chemical Hazard Symposium 2021)
ex-ovo ニワトリ胚におけるリン酸トリス(2-クロロエチル)(TCEP)の心血管毒性作用機序の解明
(第44 回鳥類内分泌研究会 2020)

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Professional career (1)：

Ph.D. (Ehime University)

Work history (7)：

2017/04 - 現在 Leading Academia in Marine and Environment Pollution Research (LaMer)
2004/11 - 現在 Ehime University Center for Marine Environmental Studies
2000/04 - 2004/10 Ehime University Center for Marine Environmental Studies
1999/02 - 2000/03 Woods Hole Oceanographic Institution Department of Biology JSPS Overseas Research Fellow
1995/07 - 2000/03 Hokkaido University Graduate School of Veterinary Medicine

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Awards (15)：

2011/07 - 日本生態学会第16回生態学琵琶湖賞
2011 - Biwako Prize For Ecology
2009 - 15th Pollutants Response in Marine Organisms (PRIMO15) Best Presentation Award
2006 - International Symposium 2006; Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes Best Presentation Award
2006 - International Symposium 2006; Pioneering Studies of Young Scientists on Chemical Pollution and Environmental Changes Best Presentation Award

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Association Membership(s) (10)：

Society of Toxicology , 日本分子生物学会 , 日本生化学会 , 日本BICER協議会 , 日本環境毒性学会 , 日本内分泌攪乱化学物質学会 , 日本獣医学会 , 環境科学会 , 日本環境化学会 , Society of Environmental Toxicology and Chemistry

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