Rchr
J-GLOBAL ID：200901046603574468   Update date: Apr. 17, 2024

Senda Toshiya

センダ トシヤ | Senda Toshiya
Affiliation and department：
High Energy Accelerator Research Organization

About High Energy Accelerator Research Organization


Homepage URL  (1)： http://pfweis.kek.jp/index.html
Research field  (1)： Structural biochemistry
Research theme for competitive and other funds  (34)：
  • 2022 - 2025 Mechanistic study of quaternary structure changes of a LysR- type transcriptional regulator
  • 2020 - 2023 GTP代謝制御によるウイルス複製阻害技術の開発
  • 2017 - 2020 Structural and functional analysis of chromatin assembly factor CAF-I
  • 2015 - 2018 Biosynthetic studies on complex natural products
  • 2012 - 2018 Structural biology of infection and carcinogenesis by Helicobacter Pylori
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Papers (212)：
  • Norie Hamaguchi-Suzuki, Naruhiko Adachi, Toshio Moriya, Satoshi Yasuda, Masato Kawasaki, Kano Suzuki, Satoshi Ogasawara, Naohiko Anzai, Toshiya Senda, Takeshi Murata. Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules. Biochemical and Biophysical Research Communications. 2024
  • Moeka Yoshikawa, Miki Senda, Hitomi Nakamura, Naoko Oda-Ueda, Tadashi Ueda, Toshiya Senda, Takatoshi Ohkuri. Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains. Biochemical and Biophysical Research Communications. 2024
  • Naoya Ohara, Norifumi Kawakami, Ryoichi Arai, Naruhiko Adachi, Akihito Ikeda, Toshiya Senda, Kenji Miyamoto. Fusion then fission: splitting and reassembly of an artificial fusion-protein nanocage. Chemical Communications. 2024
  • Yoshiki Ikeda, Mindy I Davis, Kazutaka Sumita, Yuxiang Zheng, Satoshi Kofuji, Mika Sasaki, Yoshihisa Hirota, Rajan Pragani, Min Shen, Matthew B Boxer, et al. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023. 679. 116-121
  • Xuguang Jiang, Tadayuki Ogawa, Kento Yonezawa, Nobutaka Shimizu, Sotaro Ichinose, Takayuki Uchihashi, Wataru Nagaike, Toshio Moriya, Naruhiko Adachi, Masato Kawasaki, et al. The two-step cargo recognition mechanism of heterotrimeric kinesin. EMBO reports. 2023
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MISC (99)：
  • 藤田雅也, 藤田雅也, 柴田昴耀, 菱山正二郎, 田辺幹雄, 千田俊哉, 上村直史, 政井英司. The outer membrane uptake mechanism for plant-derived aromatics in Sphingomonadaceae. 日本細菌学雑誌(Web). 2023. 78. 1
  • 藤田雅也, 田辺幹雄, 平野瞭, 西瑞穂, 上村直史, 政井英司, 千田俊哉. 細菌内膜において植物由来芳香族化合物を取り込むMFS輸送体の機能・構造解析. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
  • 濱口紀江, 濱口紀江, 安達成彦, 野中雄仁, 喜多俊介, 今野翔, 金岡優依, 守屋俊夫, 川崎政人, 安田賢司, et al. クライオ電子顕微鏡構造解析と高速AFM観察から見えてきたABCトランスポーター(P-gp)の構造ダイナミクス. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
  • 廣田佳久, 廣田佳久, 佐々木美加, SCHURDAK Jennifer, 河野龍義, 中村能久, 中村能久, 竹内恒, 千田俊哉, 佐々木敦朗, et al. Metabolic regulation by the GTP sensor PI5P4Kβ: towards the treatment of diabetes, cancer cachexia and sarcopenia. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 稲葉和恵, 海老原佳奈, 小祝孝太郎, 吉野龍ノ介, 広川貴次, 今村理世, 小島宏建, 岡部隆義, 長野哲雄, 井上英史, et al. Structure-activity relationship analysis of inhibitors targeting mosquito glutathione S-transferase Noppera-bo. 量子ビームサイエンスフェスタ(Web). 2021. 2020
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Education (3)：
  • 1992 - 1995 Nagaoka University of Technology Department of Bioengineering
  • 1988 - 1990 The University Tokyo Graduate School of Pharmaceutical Sciences
  • 1984 - 1988 The University Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 博士(工学) (長岡技術科学大学)
Work history (5)：
  • 2013/01 - 現在 High energy accelerator research organization Institute of Materials Structure Science Professor
  • 2008/04 - 2012/03 National Institute of Advanced Industrial Science and Technology biomedicinal information research center Senior Researcher
  • 2001/04 - 2007/03 National Institute of Advanced Industrial Science and Technology Biological Information Research Center Senior Researcher
  • 1995/04 - 2001/03 Nagaoka University of Technology Department of Bioengineering Research Associate
  • 1990/04 - 1992/03 Hitachi Ltd. Hitachi Advanced Research Laboratory
Awards (2)：
  • 1997 - The crystallographic society of Japan Young investigator award 3D-structure, function and evolution of type I interferons
  • The crystallographic society of Japan The CrSJ Award Structural biology of epigenetic and disease related proteins
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