AIZAWA Shin

アイザワシン | AIZAWA Shin

Affiliation and department：

Research field (3)： Hematology and oncology , Anatomy , Anatomy

Research keywords (5)： Hemopoietic stem cell , Bone marrow stromal cell , chondrocyte , low level laser irradiation , Hematopoiesis

Research theme for competitive and other funds (5)：

2018 - 2020 造血微小環境におけるストローマ細胞の構成様式と造血支持機能
2015 - 2017 骨髄造血微小環境におけるストローマ細胞の構成様式と造血制御機能発現の検討
2012 - 2015 三次元解析による骨髄ストローマ細胞の造血制御機構の検討
2011 - 2013 New rational for chemotherapy targeting transporters expressed in cancer stem cells
2011 - 2013 New rational for chemotherapy targeting transporters expressed in cancer stem cells

Papers (105)：

Takashi Koike, Katsuhiro Miura, Yoshihiro Hatta, Hideki Nakamura, Yoko Hirabayashi, Miyuki Yuda, Tomonori Harada, Shuichi Hirai, Isao Tsuboi, Shin Aizawa. Macrophage depletion using clodronate liposomes reveals latent dysfunction of the hematopoietic microenvironment associated with persistently imbalanced M1/M2 macrophage polarization in a mouse model of hemophagocytic lymphohistiocytosis. Annals of hematology. 2023. 102. 12. 3311-3323
Harada T., Tsuboi I., Utsunomiya M., Yasuda M., Aizawa S. Kinetics of leukemic cells in 3D culture with stromal cells and with arginine deprivation stress. J Biosci Bioeng. 2020. 130. 650-658
Tsuboi I., Harada T., Hirabayashi Y., Aizawa S. Dynamics of hematopoiesis is disrupted by impaired hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis. Ann Hematol. 2020. 99. 1515-1523
Hino H., Iriyama N., Kokuba H., Kazama H., Moriya S., Takano N., Hiramoto M., Aizawa S., MiyazawaK. Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes. Cancer Sci. 2020. 111. 6. 2132-2145
Iwama G., Iriuchishima T., Horaguchi T., Aizawa S. Measurement of the Whole and Midsubstance Femoral Insertion of the Anterior Cruciate Ligament: The Comparison with the Elliptically Calculated Femoral Anterior Cruciate Ligament Footprint Area. Indian J Orthop. 2019. 53. 727-731

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MISC (34)：

日野浩嗣, 田中良法, 竹谷浩介, 高野直治, 平本正樹, 相澤信, 宮澤啓介, 江藤真澄, 平井宗一. CDK4/6阻害薬abemaciclibが誘導する空胞の形成メカニズムの検討. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-493]
日野浩嗣, 入山規良, 國場寛子, 風間宏美, 森谷昇太, 高野直治, 平本正樹, 相澤信, 宮澤啓介. CDK4/6阻害薬abemaciclibはリソソームの酸性化、膨化により空胞形成を起こし、新規形式の細胞死を誘導する. 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [P-359]
Isao Tsuboi, Tomonori Harada, Yoko Hirabayashi, Shin Aizawa. Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis. Haematologica. 2019. 104. 10. 1995-2005
Suruga M., Horaguchi T., Iriuchishima T., Iwama G., Yahagi Y., Tokuhashi Y., Aizawa S. The correlation between the femoral anterior cruciate ligament footprint area and the morphology of the distal femur: three-dimensional CT evaluation in cadaveric knees. Eur J Orthop Surg Traumatol. 2019. 29. 849-854
Ayaka Kitamura, Ryohei Takata, Shin Aizawa, Hajime Watanabe, Tadashi Wada. A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart. Scientific Reports. 2018. 8. 1

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Patents (2)：

Education (2)：

Work history (1)：

2001/11 - 2023/03 Nihon University School of Medicine Anatomical Science, Functional Morphology professor

Committee career (3)：

Awards (1)：

Association Membership(s) (6)：

日本血液学会 , 日本臨床血液学会 , 日本解剖学会 , 日本内科学会 , International Society for Experimental Hematology , 日本移植学会

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