Habano Wataru

ハバノワタル | Habano Wataru

Affiliation and department：
Job title： Professor

Research field (3)： Human pathology , Clinical pharmacy , Molecular biology

Research keywords (6)：エピジェネティクス , 分子腫瘍学 , 薬物動態学 , Epigenetics , Molecular Oncology , Pharmacokinetics

Research theme for competitive and other funds (15)：

2022 - 2025 Novel roles of DNA methylation in stress response mediated by nuclear receptor AhR
2019 - 2022 Development of epigenome sensor model mediated by nuclear receptor pathway
2015 - 2018 Analysis of epigenetic alterations in tumor stromal cells and application in cancer diagnosis and treatment.
2012 - 2015 Analysis of epigenetic mechanisms on the regulation of drug metabolizing enzymes and its application to personalized drug therapy
2009 - 2011 Estimation of the role of genomic instability on drug response and its application for cancer chemotherapy.

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Papers (97)：

Ryo Sugimoto, Noriyuki Uesugi, Noriyuki Yamada, Mitsumasa Osakabe, Shigeaki Baba, Naoki Yanagawa, Yuji Akiyama, Wataru Habano, Akira Sasaki, Yoshinao Oda, et al. Gastroblastoma mimics the embryonic mesenchyme of the foregut: a case report. Diagnostic pathology. 2023. 18. 1. 24-24
Ryo Onodera, Yoko Jimma, Anna Suzuki, Wataru Habano, Shogo Ozawa, Jun Terashima. The Regulation Pathway of VEGF Gene Expression Is Different between 2D Cells and 3D Spheroids in Human Lung Cancer Cells. Biological & pharmaceutical bulletin. 2023. 46. 4. 608-613
Wataru Habano, Toshitaka Miura, Jun Terashima, Shogo Ozawa. Aryl hydrocarbon receptor as a DNA methylation reader in the stress response pathway. Toxicology. 2022. 470. 153154-153154
Toshitaka Miura, Ryo Onodera, Jun Terashima, Shogo Ozawa, Wataru Habano. β-naphthoflavone-induced upregulation of CYP1B1 expression is mediated by the preferential binding of aryl hydrocarbon receptor to unmethylated xenobiotic responsive elements. Experimental and Therapeutic Medicine. 2021. 22. 6
Tamotsu Sugai, Mitsumasa Osakabe, Wataru Habano, Yoshihito Tanaka, Makoto Eizuka, Ryo Sugimoto, Naoki Yanagawa, Takayuki Matsumoto, Hiromu Suzuki. A genome-wide analysis of the molecular alterations occurring in the adenomatous and carcinomatous components of the same tumor based on the adenoma-carcinoma sequence. Pathology international. 2021

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MISC (39)：

Yayoi Takahashi, Tamotsu Sugai, Wataru Habano, Kazuyuki Ishida, Makoto Eizuka, Koki Otsuka, Akira Sasaki, Takayuki Matsumoto, Takanori Morikawa, Michiaki Unno, et al. Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer (vol 139, pg 2493, 2016). INTERNATIONAL JOURNAL OF CANCER. 2017. 140. 1. E1-E1
山本悠貴, 神馬瑶子, 博多修子, 寺島潤, 幅野渉, 小澤正吾. ヒト肝臓がん細胞を用いた2次元培養細胞と3次元細胞塊の薬物応答解析. 日本薬学会年会要旨集(CD-ROM). 2017. 137th. ROMBUNNO.27PB-pm067
博多修子, 幅野渉, 寺島潤, 小澤正吾. ヒト大腸がん細胞株におけるDNAメチル基転移酵素阻害剤とイリノテカン併用による抗腫瘍効果増強の機構探索. 次世代を担う創薬・医療薬理シンポジウムプログラム・要旨集. 2016. 2016. 43
三浦勇生, 岡田浩司, 博多修子, 蒲生俊恵, 寺島潤, 幅野渉, 小澤正吾. ヒト大腸がん細胞株HCT-116におけるヒストン脱アセチル化阻害薬デプシペプチドによる抗がん薬イリノテカンの効果増強と,MHC class II,HLA-DQB1等の発現上昇. 日本薬学会年会要旨集(CD-ROM). 2016. 136th. ROMBUNNO.27AB-AM374
神馬瑶子, 寺島潤, 幅野渉, 小澤正吾. 発がんを誘導するAhRの肺がん細胞における役割. 次世代を担う創薬・医療薬理シンポジウムプログラム・要旨集. 2016. 2016. 33

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Patents (4)：

Education (2)：

- 1991 Tokyo University of Science Graduate School of Pharmaceutical Sciences
- 1989 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (2)：

Work history (4)：

Committee career (2)：

Awards (2)：

Association Membership(s) (4)：

日本病理学会 , 日本薬物動態学会 , 日本薬学会 , 日本癌学会

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