Rchr
J-GLOBAL ID:200901048175626060   Update date: Feb. 01, 2024

Hisaka Akihiro

ヒサカ アキヒロ | Hisaka Akihiro
Affiliation and department:
Homepage URL  (1): https://www.p.chiba-u.jp/lab/cpp/index.html
Research field  (1): Clinical pharmacy
Research keywords  (3): 臨床薬理学 ,  薬物動態学 ,  Pharmacokinetics and Clinical Pharmacology
Research theme for competitive and other funds  (14):
  • 2021 - 2024 Significance of ketone body metabolic shift in diabetes and long-term prognosis prediction
  • 2017 - 2020 Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor
  • 2015 - 2019 Expression of precipitating factors of pruritus found in humans in an imiquimodinduced psoriasis mouse model
  • 2015 - 2017 Epigenetic regulation shifted cellular metabolism of cancer cells, which contributed to potentiate drug sensitivity of antiangiogenic agents.
  • 2013 - 2015 Development of Micro-blood-sampling Method for Pharmacokinetic Analysis in Clinical Studies
Show all
Papers (59):
  • Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Hiromi Sato, Akihiro Hisaka. Involvement of multiple cytochrome P450 isoenzymes in drug interactions between ritonavir and direct oral anticoagulants. Drug Metabolism and Pharmacokinetics. 2023. 53. 100498-100498
  • Hiromi Sato, Rika Marutani, Ryota Takaoka, Daniel Mori-Fegan, Xinying Wang, Kazuya Maeda, Hiroyuki Kusuhara, Hiroshi Suzuki, Hideki Yoshioka, Akihiro Hisaka. Model-based meta-analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism. CPT: pharmacometrics & systems pharmacology. 2023. 12. 8. 1132-1142
  • Shizuka Hozuki, Hideki Yoshioka, Satoshi Asano, Mikiko Nakamura, Saori Koh, Yukihiro Shibata, Yuta Tamemoto, Hiromi Sato, Akihiro Hisaka. Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes. Clinical Pharmacokinetics. 2023. 62. 6. 849-860
  • Takahiro Arai, Tomomi Kokubo, Ruiheng Tang, Hirohito Abo, Ayu Terui, Jotaro Hirakawa, Hidetaka Akita, Hiroto Kawashima, Akihiro Hisaka, Hiroto Hatakeyama. Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor. Journal for ImmunoTherapy of Cancer. 2022. 10. 12. e005657-e005657
  • Mayu Yamamoto, Taiki Kurino, Reiko Matsuda, Haleigh Sakura Jones, Yoshito Nakamura, Taisei Kanamori, Atushi B. Tsuji, Aya Sugyo, Ryota Tsuda, Yui Matsumoto, et al. Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: Beyond EPR effect. Journal of Controlled Release. 2022. 352. 328-337
more...
MISC (43):
  • 金森大誠, 宮崎菜摘, 青木重樹, 伊藤晃成, 樋坂章博, 畠山浩人. 熱ストレス下における熱耐性卵巣癌細胞の代謝シフトの解明. 日本薬学会関東支部大会講演要旨集. 2021. 65th (CD-ROM)
  • 佐藤洋美, 副島呉竹, 副島呉竹, 樋坂章博. 薬物動態に影響する高齢者の生理学的変化と性差. 日本性差医学・医療学会学術集会プログラム・抄録集. 2021. 14th
  • 爲本雄太, 柴田侑裕, 吉友葵, 佐藤洋美, 樋坂章博. Importance of systematic assessment of time-dependent inhibition of CYP isozymes: inhibition of CYP1A2 and CYP2C19 by fluvoxamine. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
  • Hideki Yoshioka, Akihiro Hisaka, Yasunori Sato. Proposal of a New Risk Score for Hospital Death Due to Acute Coronary Syndrome Developed by Machine Learning. CIRCULATION RESEARCH. 2020. 127. 12. E281-E281
  • 爲本雄太, 柴田侑裕, 保月静香, 佐藤洋美, 樋坂章博. 代謝寄与率(fm)の評価に与える緩衝液条件の影響:in vitroカクテル法による検討. 臨床薬理. 2020. 51. Supplement
more...
Books (3):
  • 医療現場のための薬物相互作用リテラシー
    南山堂 2019 ISBN:9784525776015
  • これからの薬物相互作用マネジメント : 臨床を変えるPISCSの基本と実践
    じほう 2014 ISBN:9784840745604
  • トランスポーター活性を考慮した薬物吸収動態の統合的解析
    樋坂章博 2010
Education (2):
  • Hokkaido University Faculty of Pharmaceutical Sciences Department of Pharmacy
  • Hokkaido University
Committee career (2):
  • HAB研究機構 理事
  • 日本薬物動態学会 評議員
Association Membership(s) (8):
国際薬物動態学会 ,  日本ファーマコメトリクス研究会 ,  日本TDM学会 ,  日本臨床薬理学会 ,  日本医療薬学会 ,  日本薬剤学会 ,  日本薬物動態学会 ,  日本薬学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page