Rchr
J-GLOBAL ID:200901048793957190   Update date: Jan. 30, 2024

Koumura Tomoko

Koumura Tomoko
Research field  (1): Pharmaceuticals - health and biochemistry
Research keywords  (2): 生化学 ,  Biopharmaceutics
Research theme for competitive and other funds  (4):
  • 2007 - 2008 Analysis of mechanism of cell death during ischemia-reperfusion
  • 2002 - 2003 The mechanism of protection of apoptosis by the mitochondrial PHGPx
  • カルジオリピン含量変動による細胞死制御の解析
  • -
Papers (23):
  • Kosei Ishimaru, Masataka Ikeda, Hiroko Deguchi Miyamoto, Shun Furusawa, Ko Abe, Masatsugu Watanabe, Takuya Kanamura, Satoshi Fujita, Ryohei Nishimura, Takayuki Toyohara, et al. Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A. Journal of the American Heart Association. 2023. e9114
  • Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, et al. Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. Science signaling. 2022. 15. 758. eabn8017
  • Hiroko Deguchi Miyamoto, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Shun Furusawa, Ko Abe, Kosei Ishimaru, Nobuyuki Enzan, Masashi Sada, Taishi Yamamoto, et al. Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury. JACC. Basic to translational science. 2022. 7. 8. 800-819
  • Kunihiro Azuma, Tomoko Koumura, Ryo Iwamoto, Masaki Matsuoka, Ryo Terauchi, Shu Yasuda, Tomoyasu Shiraya, Sumiko Watanabe, Makoto Aihara, Hirotaka Imai, et al. Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice. The Journal of biological chemistry. 2022. 298. 4. 101824-101824
  • Tomonori Tadokoro, Masataka Ikeda, Tomomi Ide, Hiroko Deguchi, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Shouji Matsushima, Tomoko Koumura, Ken-Ichi Yamada, et al. Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity. JCI insight. 2020. 5. 9
more...
MISC (15):
  • 今井 浩孝, 一ノ瀬 栞, 小川 丈博, 松岡 正城, 幸村 知子. 1-III-9 心臓特異的PHGPx欠損マウスを用いたビタミンE低下による突然死の解析(一般演題要旨,ビタミン・バイオファクター研究のさらなる魅力〜大和まほろぱからの発信〜,第67回大会講演要旨). ビタミン. 2015. 89. 4. 227-227
  • Hiroko P. Indo, Osamu Inanami, Tomoko Koumura, Shigeaki Suenaga, Hsiu Chuan Yen, Shizuko Kakinuma, Ken Ichiro Matsumoto, Ikuo Nakanishi, William St Clair, Daret K, et al. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radical Research. 2012. 46. 8. 1029-1043
  • Minako Karahashi, Tomoko Koumura, Kiyoshi Kawasaki, Masahiro Nishijima, Yasuhito Nakagawa. Reduction of mitochondrial cardiolipin induces apoptosis stimulated by staurosporine. CHEMISTRY AND PHYSICS OF LIPIDS. 2008. 154. S23-S24
  • 中川 靖一, 幸村 知子, 今井 浩孝. ミトコンドリア型グルタチオンペルオキシダーゼIVの機能解析. 脂質生化学研究. 2008. 50. 25-25
  • Y Nakagawa, T Koumura, C Nakamura. Involvement of hydroperoxide in mitochondria in the induction of apoptosis by the eicospentaenoic acid. FREE RADICAL RESEARCH. 2005. 39. S72-S72
more...
Lectures and oral presentations  (7):
  • 心臓特異的GPx4欠損マウスの心不全突然死抑制効果を示す抗生剤の探索
    (日本薬学会第142年会 2022)
  • CPZ耐性腸内細菌がビタミンE低下による脂質酸化依存的心突然死を抑制する
    (第94回日本生化学会大会 2021)
  • 心臓特異的GPx4欠損マウスの心不全突然死抑制効果を示す抗生剤の同定
    (フォーラム2021 衛生薬学・環境トキシコロジー 2021)
  • 抗生剤セフォペラゾン耐性腸内細菌が脂質酸化依存的心不全突然死を抑制する
    (第34回北里大学バイオサイエンスフォーラム 2021)
  • 抗生剤CPZ耐性腸内細菌が脂質酸化依存的心不全突然死を抑制する
    (日本薬学会第141年会 2021)
more...
Education (4):
  • - 2001 Kitasato University
  • - 2001 Kitasato University Graduate School, Division of Pharmaceutical Sciences
  • - 1998 Kitasato University School of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences
  • - 1998 Kitasato University Faculty of Pharmaceutical Science
Professional career (1):
  • (BLANK) (Kitasato University)
Association Membership(s) (2):
日本生化学会 ,  日本薬学会
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