Rchr
J-GLOBAL ID：200901049241691176
Update date: Apr. 19, 2024
Rikinari HANAYAMA,
ハナヤマ リキナリ | Rikinari HANAYAMA,
Affiliation and department：
Other affiliations (1)：
Homepage URL (2)：
http://immunology.w3.kanazawa-u.ac.jp
,
http://immunology.w3.kanazawa-u.ac.jp/index2.html
Research field (3)：
Medical biochemistry
, Physiology
, Immunology
Research keywords (5)：
Exosome
, Extracellular Vesicle
, Immunoregulation
, Neurodegeneration
, Tumor Progression
Research theme for competitive and other funds (27)：
- 2024 - 2028 Elucidation of bio-regulatory mechanisms by brain-derived exosomes
- 2023 - 2027 Exosomes derived from intestinal bacteria and their prophylaxis in bronchial asthma caused by chemicals in the environment.
- 2023 - 2026 Innovative immunosuppression after organ transplantation using modified exosomes
- 2019 - 2026 WISE Program for Nano-Precision Medicine, Science, and Technology
- 2023 - 2025 Development of in vivo production technology of engineered exosomes inducing anti-tumor immunity
- 2022 - 2025 Establishment of a new biomarker using platelets for personalized treatment of pancreatic cancer
- 2018 - 2025 Elucidation and control of the interaction of biological responses by microparticles
- 2019 - 2024 Development of innovative immunoregulatory methods using designer exosomes
- 2019 - 2023 Exosomes and their miRNAs as central players in environmental chemical-induced bronchial asthma
- 2019 - 2023 Elucidation of the mechanism of hemophagocytosis by abnormal activation of macrophages
- 2019 - 2022 Elucidation of the function of exosomes in neural circuit reconstruction
- 2018 - 2021 Function of the macrophage lysosome-related molecule myoferlin in obesity-induced adipose inflammation.
- 2018 - 2021 Microenvironmental maintenance by exosome-mediated microglia from malignant glioma
- 2016 - 2019 Pathogenesis of exosome-mediated autoinflammation in the brain
- 2016 - 2019 Elucidation of the pathogenic mechanism of multiple system atrophy mediated by neuronal exosomes
- 2016 - 2018 Elucidation of the pathology caused by melting of others and development of visualization technology using MRI
- 2014 - 2017 Identification of novel tumor markers by high-purity exosome purification method
- 2013 - 2017 Physiological functions of secretory membrane vesicle exosomes and their target cells
- 2014 - 2016 Role of neuronal exosomes in Parkinson's disease
- 2012 - 2016 Mechanism of lysosomal exocytosis by inflammatory macrophages
- 2012 - 2015 Development of Novel Antiviral Drugs and Vaccines Targeting the Lipid Bilayer of Hepatitis Viruses
- 2011 - 2015 Private Research Grants
- 2011 - 2014 Molecular mechanisms of axon pruning by glial cells
- 2012 - 2014 Maintenance mechanism of brain environment via phagocytosis by glial cells and its disruption
- 2010 - 2013 Elucidation of the operating principle of phagocytosis of apoptotic cells
- 2005 - 2008 Role of myocyte enhancer factor 2 in synapse development
- 2002 - 2004 Molecular mechanism of apoptotic cell recognition and phagocytosis by macrophages
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Papers (56)：
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Kouyuki Hirayasu, Seik-Soon Khor, Yosuke Kawai, Mihoko Shimada, Yosuke Omae, Gen Hasegawa, Yuko Hashikawa, Hiromu Tanimoto, Jun Ohashi, Kazuyoshi Hosomichi, et al. Identification of the hybrid gene LILRB5-3 by long-read sequencing and implication of its novel signalling function. Frontiers in Immunology. in press. 2024
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Arisa Hori, Saori Toyoura, Miyu Fujiwara, Ren Taniguchi, Yasutaka Kano, Tomoyoshi Yamano, Rikinari Hanayama, Masafumi Nakayama. MHC class I-dressing is mediated via phosphatidylserine recognition and is enhanced by polyI:C. iScience. in press. 2024
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Hisano Kobayashi, Takayuki Shiba, Takeshi Yoshida, Dilireba Bolidong, Koroku Kato, Yoshiki Sato, Mao Mochizuki, Takafumi Seto, Shuichi Kawashiri, Rikinari Hanayama. Precise analysis of single small extracellular vesicles using flow cytometry. Scientific Reports. 2024. 14. 1. 7465-7465
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Takeshi Yoshida, Kenji Goto, Akihito Kodama, Dilireba Bolidong, Takafumi Seto, Rikinari Hanayama. Extracellular vesicles promote silica nanoparticle aggregation that inhibits silica-induced cytotoxicity. Archives of Biochemistry and Biophysics. 2024. 755. 109964-109964
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Hirotomo Dochi, Satoru Kondo, Shigetaka Komura, Makiko Moriyama-Kita, Takeshi Komori, Asuka Nanbo, Miako Sakaguchi, Masaki Fukuyo, Toshihide Hamabe-Horiike, Mariko Tanaka, et al. Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein-Barr virus: A poor prognostic marker. International Journal of Cancer. 2024. 154. 5. 895-911
ｍore...
MISC (21)：
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Yoshihiro Araki, Hiroyuki Tsuchiya, Rikinari Hanayama. Potential clinical applications of microRNAs derived from osteosarcoma cells. Precision Medicine. 2024. 7. 4. 71-76
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Kenji Goto, Takeshi Yoshida, Yayoi Inomata, Rikinari Hanayama, Akifumi Seto. Elucidation of biological responses to atmospheric particulates. Seikagaku. 2023. 95. 2. 151-156
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Tomoyoshi Yamano, Rikinari Hanayama. Roles of Aire in T-cell peripheral immune tolerance. Clinical Immunology and Allergology. 2022. 58. 3. 19-24
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Hironori Kawahara, Yasutake Tada, Rikinari Hanayama. Explanation about exosome. Clinical Neuroscience. 2022. 40. 7. 830-833
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Rikinari Hanayama. EV research at fever pitch. Experimental Medicine. 2021. 39. 20. 2-8
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Patents (8)：
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Compositions for regulating CAR-T cell activation, hematopoietic stem cell proliferation, and iPS cell differentiation, and use thereof
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Immunoregulatory method, nucleic acid for immunoregulation and use thereof 2
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Immunoregulatory method, nucleic acid for immunoregulation and use thereof 1
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Antigen-presenting extracellular vesicles
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Prognostic or assisted prognostic methods for bone tumors
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Books (12)：
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Experimental Medicine: Neurodegenerative diseases
Yodosha 2023
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Experimental Medicine: New Macrophage
Yodosha 2022
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Experimental Medicine: Biology of EVs
Yodosha 2021
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Experimental Medicine: New Generation Flow Cytometry
Yodosha 2021
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JB Special Issue-Medical chemistry of extracellular vesicles
Oxford Academic 2021
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Lectures and oral presentations (119)：
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17th European meeting on glial cells in health and disease
(Marseille, France 2025)
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41th Annual Meeting of the Japanese Society of Toxicologic Pathology
(Mishima 2025)
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65th Annual Meeting of Japan Society for Atmospheric Environment
(Hiyoshi 2024)
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40th Annual Meeting of the Japan Society of Drug Delivery System
(Tsukuba 2024)
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97th Annual Congress of the Japan Endocrine Society
(Yokohama 2024)
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Education (3)：
- 2000 - 2004 Ph.D, Osaka University (Advisor: Prof. Shigekazu Nagata)
- 1993 - 1999 MD, Osaka University
- 1990 - 1993 Takatsuki High School
Professional career (1)：
- MD, PhD (Osaka University)
Work history (12)：
- 2019 - 現在 Coordinator, WISE Program for Nano-Precision Medicine, Science, and Technology, Kanazawa University
- 2018 - 現在 JST CREST Investigator
- 2017 - 現在 Professor, WPI Nano Life Science Institute, Kanazawa University
- 2015 - 現在 Professor, Department of Immunology, Graduate School of Medical Sciences, Kanazawa University
- 2015 - 2017 Program Officer, KAKENHI, MEXT
- 2012 - 2016 JST PRESTO Investigator
- 2011 - 2015 Associate Professor, WPI Immunology Frontier Research Center, Osaka University
- 2008 - 2011 Assistant Professor, Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- 2005 - 2008 HFSP Fellow, Harvard Medical School (Dr. Mike Greenberg Lab)
- 2004 - 2005 Instructor, Department of Genetics, Graduate School of Medicine, Osaka University
- 2002 - 2004 Pre-doctoral Fellow, JSPS
- 1999 - 2000 Intern in Medicine, Osaka University Hospital
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Committee career (13)：
- 2023 - 現在 Acting Member, Research Funding Subcommittee, Council for Science and Technology, MEXT
- 2022 - 現在 Member, Office of Reform and Research Strategy, Kanazawa University
- 2020 - 現在 Steering Committee Member, JST FOREST Program
- 2019 - 現在 Advisor, FUJIFILM
- 2019 - 現在 Councilor, The Japanese Society for Immunology
- 2019 - 現在 Councilor, The Japanese Biochemical Society
- 2016 - 現在 Editorial Board, Scientific Reports
- 2022 - 2024 Advisory Committee Member, Institute for Protein Research, Osaka University
- 2022 - 2023 Diversity and Career Support Committee Member, The Japanese Society for Immunology
- 2021 - 2023 Vice Chairman, The Science Board Subcommittee, PMDA
- 2018 - 2023 Associate Editor, The Journal of Biochemistry
- 2018 - 2023 日本生化学会 JB編集委員
- 2016 - 2022 Assembly Director, The Juzen Medical Society of Kanazawa University
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Awards (9)：
- 2021 - JB Reviewer Award
- 2019 - Kanazawa University Merit Award
- 2014 - Osaka University Presidential Award
- 2012 - Astellas Biomedical Award
- 2011 - HFSP Career Development Award
- 2009 - MEXT Young Scientists’ Prize
- 2006 - GE & Science Prize for Young Life Scientists (AAAS)
- 2004 - Yamamura Award(Osaka University)
- 1999 - Yamamura Award(Osaka University)
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Association Membership(s) (3)：
International Society for Extracellular Vesicles (ISEV)
, The Japanese Society for Immunology
, The Japanese Biochemical Society
