Shimokawa Toshibumi

シモカワトシブミ | Shimokawa Toshibumi

Affiliation and department：

Research field (3)： Immunology , Functional biochemistry , Molecular biology

Research keywords (14)： protein-protein interaction , C/EBP , Ets , gene expression , myeloid differentiation , RNA splicing , promoter , Fc receptor , IgA , immunoglobulin , splicing , transcription , gene expression , Fc receptor

Research theme for competitive and other funds (1)：

2016 - 2019 C/EBPαの新規C末端機能領域を介した顆粒球系細胞分化経路の分子機構の解明

Papers (28)：

Y. Okayama, A. Matsuda, J. -I. Kashiwakura, T. Sasaki-Sakamoto, S. Nunomura, T. Shimokawa, K. Yamaguchi, S. Takahashi, C. Ra. Highly expressed cytoplasmic Fc epsilon RIb in human mast cells functions as a negative regulator of the FcR gamma-mediated cell activation signal. CLINICAL AND EXPERIMENTAL ALLERGY. 2014. 44. 2. 238-249
Toshibumi Shimokawa, Satoshi Nunomura, Daisuke Fujisawa, Chisei Ra. Identification of the C/EBP alpha C-terminal tail residues involved in the protein interaction with GABP and their potency in myeloid differentiation of K562 cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS. 2013. 1829. 11. 1207-1217
Mervi Ristola, Satu Arpiainen, Toshibumi Shimokawa, Chisei Ra, Jukka Tienari, Moin A. Saleem, Harry Holthofer, Sanna Lehtonen. Regulation of nephrin gene by the Ets transcription factor, GA-binding protein. NEPHROLOGY DIALYSIS TRANSPLANTATION. 2013. 28. 4. 846-855
Mamiko Kajiwara, Takahiro Ueno, Noboru Fukuda, Hiroyuki Matsuda, Toshibumi Shimokawa, Maki Kitai, Akiko Tsunemi, Yoshinobu Fuke, Takayuki Fujita, Koichi Matsumoto, et al. Development of pyrrole-imidazole polyamide targeting Fc receptor common gamma chain for the treatment of immune-complex related renal disease. Biological and Pharmaceutical Bulletin. 2012. 35. 11. 2028-2035
Tomoyoshi Terada, Satoshi Nunomura, Toshibumi Shimokawa, Koichi Murayama, Seiichi Era, Naomi Kondo, Chisei Ra. FcεRI-induced mast cell cytokine production critically involves an aspartic acid residue (D234) in the C-terminal intracellular domain of the FcεRIβ chain. Biochemical and Biophysical Research Communications. 2011. 410. 4. 744-748

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MISC (1)：

Transcriptional regulation of FcαR and granulopoiesis. 2015. 63. 6. 577-584

Books (2)：

医薬バイオテクノロジー辞典
廣川書店 2003
Regulation of human FcαR gene expression
Activating and inhibitory immunoglobulin-like receptor, Springer 2001

Lectures and oral presentations (98)：

好中球分化におけるC/EBPαC末端のGABP会合領域の解析
(第77回日本血液学会学術集会 2015)
骨髄細胞分化におけるC/EBPαのC-末端領域の解析
(第64回日本アレルギー学会学術大会 2015)
関節リウマチ(RA)患者滑膜組織マスト細胞におけるIL-17の発現
(第64回日本アレルギー学会学術大会 2015)
好中球分化におけるC/EBPαのC末端領域の解析
(第76回日本血液学会学術集会 2014)
好中球分化におけるC/EBPαのC 末端GABP 相互作用領域の解析
(第36回日本分子生物学会年会 2013)

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Education (3)：

- 1993 Yokohama City University Graduate School, Division of Medicine Bacteriology
- 1989 Saitama University Graduate School, Division of Science Biochemistry
- 1987 Saitama University Faculty of Science Biochemistry

Professional career (2)：

Doctor (Medicine) (Yokohama City University)
Master (Saitama University)

Work history (7)：

2007/07/01 - Nihon University School of Medicine
2005/09/01 - 2007/06/30 Nihon University Graduate School of Medicine
2001/06/01 - 2005/06/30 Nihon University Graduate School of Medicine
1996/04/01 - 2002/03/31 Juntendo University Faculty of Medicine
1996/11/01 - 2001/03/31 科学技術振興事業団研究員(CREST)

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Committee career (1)：

2011/05 - 2013/05 日本アレルギー学会代議員

Association Membership(s) (4)：

The Molecular Biology Society of Japan , Japanese Society for Immunology , Japanese Society of Allergology , 日本血液学会

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