Rchr
J-GLOBAL ID:200901049597997873   Update date: Feb. 14, 2024

Hashimoto Yuichi

ハシモト ユウイチ | Hashimoto Yuichi
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www.iam.u-tokyo.ac.jp/chem/index.html
Research field  (1): Pharmaceuticals - chemistry and drug development
Research keywords  (2): 生物有機化学 ,  Bioorganic Chemistry
Research theme for competitive and other funds  (53):
  • 2017 - 2020 Structural and functional development studies of ligands for disease progression factors
  • 2016 - 2019 Development of silicon-containing units as expanded bioisosters
  • 2014 - 2017 Polypharmacology based on dynamism of the target protein
  • 2013 - 2015 Chemical biology of trafficking regulation of membrane cholesterol transporter protein
  • 2010 - 2014 Chemical control of protein dramatype
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Papers (11):
  • Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, et al. Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties. ACS Medicinal Chemistry Letters. 2022. 13. 3. 396-402
  • Yuki Ichikawa, Michiaki Hiramatsu, Yusuke Mita, Makoto Makishima, Yotaro Matsumoto, Yui Masumoto, Atsuya Muranaka, Masanobu Uchiyama, Yuichi Hashimoto, Minoru Ishikawa. meta-Non-flat substituents: a novel molecular design to improve aqueous solubility in small molecule drug discovery. Organic & Biomolecular Chemistry. 2021. 19. 2. 446-456
  • Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane. Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs. PLOS ONE. 2020. 15. 12. e0243746-e0243746
  • Shinpei Murasawa, Katsuya Iuchi, Shinichi Sato, Tomomi Noguchi-Yachide, Mikiko Sodeoka, Tsutomu Yokomatsu, Kosuke Dodo, Yuichi Hashimoto, Hiroshi Aoyama. Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene. Bioorganic and Medicinal Chemistry. 2012. 20. 21. 6384-6393
  • Hiroshi Aoyama, Kumiko Sako, Shinichi Sato, Masahiko Nakamura, Hiroyuki Miyachi, Yukinori Goto, Mika Okamoto, Masanori Baba, Yuichi Hashimoto. Polymethylated γ-carbolines with potent anti-bovine viral diarrhea virus (BVDV) activity. Heterocycles. 2009. 77. 2. 779-785
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MISC (11):
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Patents (7):
  • Benzodiazepine derwatives as preventives/remedies for diabetes
  • Medical composition
  • サイトカイニン結合蛋白質
  • 医薬組成物
  • 抗アンドロゲン剤
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Books (2):
  • 生体有機化学
    東京化学同人 2012
  • ベーシック薬学教科書シリーズ6「創薬科学・医薬化学」第6章「創薬研究の基礎知識ーーー標的となる生体分子」
    化学同人 2007
Education (4):
  • - 1982 The University of Tokyo
  • - 1982 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1977 The University of Tokyo Faculty of Pharmaceutical Sciences
  • - 1977 The University of Tokyo Faculty of Pharmaceutical Science
Professional career (2):
  • Pharmaceutical Doctor
  • 薬学修士 (東京大学)
Work history (10):
  • 2020/06 - Emeritus Professor
  • 2020/03 - 定年退職
  • 1997 - The University of Tokyo Institute of Molecular and Cellular Biosciences
  • 1997 - professor, Institute of Molecular and Cellular Biosciences,
  • 1989 - 東京大学応用微生物研究所助教授
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Committee career (2):
  • 2007 - 日本薬学会医薬化学部会 役員
  • 2000 - 日本ビタミン学会 理事
Awards (4):
  • 2006 - 日本薬学会創薬科学賞
  • 1986 日本薬学会奨励賞
  • Pharmaceutical Society of Japan
  • 1986 Promoting Award for Pharmaceutical Sciences,
Association Membership(s) (8):
日本ビタミン学会 ,  米国化学会 ,  日本薬学会 ,  日本癌学会 ,  The Vitamin Society of Japan ,  The Pharmaceutical Society of Japan ,  Japanese Cancer Association ,  American Chemical Society
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