TAKASHI NISHINO

ニシノタカシ | TAKASHI NISHINO

Affiliation and department：
Job title： Associate Professor

Research field (4)： Pharmaceuticals - chemistry and drug development , Hematology and oncology , Functional biochemistry , Applied biofunctional and bioprocess engineering

Research keywords (2)：糖鎖生物学 , Glycobiology

Research theme for competitive and other funds (6)：

2007 - 2009 Regioselective glycosylation of fully unprotected sugars by means of molecular recognition using arylboronic acid
2005 - 2007 Total Synthesis for Elucidation of Structure - Activity Relationships of Antiviral Fattiviracin
1994 - 1994 褐藻植物由来フコイダンの抗血液凝固機構に関する研究
1993 - 1993 褐藻植物ヒバマタ由来市販フコイダンの抗血液凝固活性多糖の検索ならびにその構造解析
多糖の構造と生理活性との相関性に関する研究

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Papers (13)：

Tatsuya Shirahata, Rintaro Miyashita, Tatsuki Kitazoe, Masaya Saito, Yuki Taneoka, Shuhei Hidaka, Masaki Yokoyama, Takanori Tojima, Tatsuya Katsumi, Nozomu Hirata, et al. Preparation of Tenuofolin from Polygala senega L.Root Using a Hydrolytic Continuous Flow System under High-Temperature, High-Pressure Conditions. J Org Chem. 2021. 86. 16268-16277
Konishi N, Shirahata T, Yokoyama M, Katsumi T, Iyo Y, Hirata N, Nishino T, Makino K, Sato N, Nagai T, et al. Synthesis of bisdesmosidic oleanolic acid saponins via a glycosylation-deprotection sequence under continuous microfluidic/batch conditions. J Org Chem. 2017. 82. 13. 6703-6719
Shirahata T, Nagai T, Hirata N, Yokoyama M, Katsumi T, Konishi N, Nishino T, Makino K, Yamada H, Kaji E, et al. Syntheses and mucosal adjuvant activity of simplified oleanolic acid saponins possessing cinnamoyl ester. Bioorg Med Chem. 2017. 25. 6. 1747-1755-1755
Fukuhara K, Shimada N, Nishino T, Kaji E, Makino K. Regioselective, tin-free sulfation of unprotected hexopyranosides by u sing phenylboronic acid. Eur J Org Chem. 2016. 2016. 5. 902-905
Kaji E, Yamamoto D, Shirai Y, Ishige K, Arai Y, Shirahata T, Makino K, Nishino T. Thermodynamically controlled regioselective glycosylation of fully unprotected sugars through Bis(boronate) Intermediates. Eur J Org Chem. 2014. 2014. 17. 3536-3539

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MISC (20)：

西野貴司. アリールボロン酸ダイマーの分子認識を利用した糖鎖の効率的合成法の開発. 平成19年度科学研究費補助金(基礎研究(C)) 研究実績報告書. 2008
T Nishino, T Yamauchi, M Horie, T Nagumo, H Suzuki. Effects of a fucoidan on the activation of plasminogen by u-PA and t-PA. THROMBOSIS RESEARCH. 2000. 99. 6. 623-634
T Nishino, A Fukuda, T Nagumo, M Fujihara, E Kaji. Inhibition of the generation of thrombin and factor Xa by a fucoidan from the brown seaweed Ecklonia kurome. THROMBOSIS RESEARCH. 1999. 96. 1. 37-49
T NISHINO, H URA, T NAGUMO. THE RELATIONSHIP BETWEEN THE SULFATE CONTENT AND THE ANTITHROMBIN ACTIVITY OF AN ALPHA(1-]2)-FUCOIDAN PURIFIED FROM A COMMERCIAL FUCOIDAN FRACTION. BOTANICA MARINA. 1995. 38. 3. 187-193
T NISHINO, C NISHIOKA, H URA, T NAGUMO. ISOLATION AND PARTIAL CHARACTERIZATION OF A NOVEL AMINO SUGAR-CONTAINING FUCAN SULFATE FROM COMMERCIAL FUCUS-VESICULOSUS FUCOIDAN. CARBOHYDRATE RESEARCH. 1994. 255. 213-224

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Patents (1)：

5-アミノレブリン酸誘導体及びその塩

Books (8)：

薬局方試験法概要と演習第9版
廣川書店 2015 ISBN:9784567011174
薬学用語辞典
東京化学同人 2012
薬局方試験法概要と演習
廣川書店 2011
薬局方試験法概要と演習第8版
廣川書店 2009
薬局方試験法-概要と演習-第8版
廣川書店 2007

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Lectures and oral presentations (43)：

Moronic acid mediated regioselective sulfation of unprotected carbohydrates
(第34回日本糖質学会年会 2015)
The study on efficient glycosylation of C3 position in oleanolic acid by using a micro flow reactor
(日本薬学会第135年会 2015)
アジュバント活性試験への供給を目的とするマイクロフローリアクターを用いたオレアノール酸C3、28位の配糖化の検討
(第68回有機合成化学協会関東支部シンポジウム 2014)
マイクロフローリアクターを用いたオレアノール酸C28位の配糖化の検討とインフルエンザウイルスに対するアジュバント活性の測定
(GlycoTOKYO 2014 2014)
Glycosylation of oleanolic acid at C28 by using Flow Microreactor and evaluation of adjuvant activity against influenza virus
(The 8th JSP-CCTGNM-KSP Joint Symposium on Pharmacognosy 2014)

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Education (5)：

1983 - 1985 Kitasato University Graduate School, Division of Pharmaceutical Sciences 薬学専攻
- 1985 Kitasato University
- 1985 Kitasato University 薬学研究科
1978 - 1982 Kitasato University Faculty of Pharmaceutical Science 製薬学科
- 1982 Kitasato University Faculty of Pharmaceutical Science

Professional career (1)：

博士(薬学) (北里大学)

Work history (12)：

2013/04/01 - 薬学部・准教授
2012/04/01 - 慶応義塾大学・非常勤講師
2006/04/01 - 2012/03/31 薬学部・講師
2006/04/01 - 2009/03/31 慶応義塾大学・非常勤講師
2004/04/01 - 2006/03/31 薬学部・助手

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Awards (1)：

2016/11/10 - 平成28年度前期優秀教育賞必須科目「医薬品化学」(4年生)

Association Membership(s) (4)：

日本糖質学会 , 日本薬学会 , 日本薬学教育学会 , 日本生化学会

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