2019 - 2022 Elucidation of cancer proliferation mechanisms based on signal transduction from organelles different from normal cells
2020 - 2022 非対称糖鎖構造を持つIgG 作製とその機能評価
2016 - 2019 Identification of intracellular activation sites of mutated tyrosine kinases in tumor cells and drug development based on the cellular localization
2016 - 2018 Basic research for development of the DDS system considering tissue and intracellular drug distribution
2015 - 2018 Elucidation of the chemoresistance in pancreatic cancer and development of its tumor stroma targeting ADCs
2015 - 2018 C-Mannosylation is involved in the regulation of epithelial-cell adhesion.
2015 - 2018 1,2-cis aminoglycoside synthesis by anomerization stragegy
2015 - 2017 Development of a novel antibody gene complex for the gene therapy of heart failure.
2012 - 2016 Synthesis of Biologically Active Oligosaccharide Using Anomerization Reaction via Endocyclic Cleavage Reaction
2010 - 2012 Analysis of the tumor biological factor regulating the antibody-delivery
2009 - 2011 The Unique Reactivity of Conformationally Restricted Pyranosides
2008 - 2010 Protein C-mannosylation and signaling related to innate immunity
2005 - 2009 Development of drug or gene delivery system for clinical application.
2004 - 2009 遺伝子およびドラッグデリパリーシステムのがん臨床応用をめざす研究
2007 - 2008 Origin of the high stereoselectivity of glycosyl donors
2004 - 2005 新規C-結合型糖鎖修飾ペプチドの合成と生物学的意義解明
2002 - 2005 糖鎖迅速合成と多様性指向型合成への挑戦
2001 - 2003 Organic Synthesis of Glycoprotein Structural Motifs
2001 - 2002 糖鎖固相合成反応のモニタリング法確立と新規リンカーの開発
1998 - 1999 固相における多成分カップリングによる高効率的糖鎖合成
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Papers (132)：
Methanee Hiranyakorn, Shogo Iwamoto, Asako Hoshinoo, Ryo Tsumura, Hiroki Takashima, Masahiro Yasunaga, Shino Manabe. Chromatographic Analysis of the N-Glycan Profile on Therapeutic Antibodies Using FcγRIIIa Affinity Column Chromatography. ACS Omega. 2023. 8. 18. 16513-16518
Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Yoshito Ihara. Functions of Protein C-Mannosylation in Physiology and Pathology. Trends in Glycoscience and Glycotechnology. 2023. 35. 204. E23-E27
Yahani P. Jayasinghe, Michael T. Banco, Jared J. Lindenberger, Lorenza Favrot, Zuzana Palčeková, Mary Jackson, Shino Manabe, Donald R. Ronning. The Mycobacterium tuberculosis mycothiol S-transferase is divalent metal-dependent for mycothiol binding and transfer. RSC Medicinal Chemistry. 2023. 14. 3. 491-500
Hiroki Takashima, Kazunobu Ohnuki, Shino Manabe, Yoshikatsu Koga, Ryo Tsumura, Takahiro Anzai, Yang Wang, Xiaojie Yin, Nozomi Sato, Yudai Shigekawa, et al. Tumor Targeting of 211At-Labeled Antibody under Sodium Ascorbate Protection against Radiolysis. Molecular pharmaceutics. 2022. 20. 2. 1156-1167
Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Kenji Uchimura, Yukishige Ito, Yoshito Ihara. Thrombospondin type 1 repeat-derived C-mannosylated peptide attenuates synaptogenesis of cortical neurons induced by primary astrocytes via TGF-β. Glycoconjugate journal. 2022. 39. 5. 701-710
西辻和親, 池崎みどり, 眞鍋史乃, 眞鍋史乃, 井原義人. Functions of Protein C-Mannosylation in Physiology and Pathology. Trends in Glycoscience and Glycotechnology (Web). 2023. 35. 204
森慧大, 眞鍋史乃, 眞鍋史乃. Synthetic Approach of Non-human Type N-Glycan. 日本糖質学会年会要旨集. 2023. 42nd
本賢一, 眞鍋史乃, 眞鍋史乃, 鈴木匡. Isolation of a C-mannosyl tryptophan-assimilating bacterium from soil. 日本糖質学会年会要旨集. 2023. 42nd
北山慎太郎, 冨樫圭祐, 眞鍋史乃, 眞鍋史乃, 一柳剛. Synthesis of a pentasaccharide of neisserial LOS via the anomerization of pyranoside with 2,3-trans carbamate. 日本糖質学会年会要旨集. 2023. 42nd
Expansion of Glycoscience from Organic Chemistry
(International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society Japan 2023)
日本抗体学会
, 日本分子イメージング学会
, 日本核医学会
, THE JAPANESE SOCIETY OF APPLIED GLYCOSCIENCE
, THE JAPANESE CANCER ASSOCIATION
, 日本薬学会
, 日本化学会
, 有機合成化学協会
, 日本農芸化学会
, 日本糖質学会
, アメリカ化学会
, 日本DDS 学会
, FCAA(Forum: Carbohydrate Coming of Age)
, 日本プロセス学会
, 日本ケミカルバイオロジー学会
