Research field (2)：
Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (2)：
Pharmacokinetics
, Toxicology
Research theme for competitive and other funds (26)：
2021 - 2026 医療系学部・大学院の全員留学による学びの包括的評価に関する実証研究
2021 - 2025 Scientific research of the onset mechanism of drug-induced idiosyncratic toxicity to avoid serious side effects
2019 - 2023 HLA多型の構造的特徴に基づく皮膚特異的な過敏症リスク薬物の評価系構築
2018 - 2019 Construction of an in vivo model for prediction of fulminant type DILI in preclinical/clinical
2015 - 2019 Elucidation of the pathogenesis of idiosyncratic drug-induced liver injury using HLA-transfected mice for establishment of preclinical prediction method
2015 - 2017 Elucidation of the onset mechanism of abacavir-induced severe skin reaction using humanized model animal
2014 - 2017 Fundamental study for integrated understanding of the mechanism of DILI and its prediction
2012 - 2016 Basis study for the prediction of fatal DILI risk based on MHC expression in the liver
2013 - 2015 Construction of improved lymphocyte transformation test based on the onset and aggravation mechanism of drug-induced liver injury
2010 - 2012 Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYP
2010 - 2011 Analysis of the molecular mechanism of hepatic GSH decrease during drug induced liver injury.
2005 - 2009 Analysis of the function and regulatory mechanism of drug transportsome
2007 - 2008 Establishment of quantitative prediction method for the individual variabilities in hematologic toxicity of anti-cancer agents
2006 - 2007 Investigation on the molecular mechanism of NPC1L1-mediated cholesterol uptake
2006 - 2007 Systematic analysis of intestinal absorption process considering drug transportation across membranes
2005 - 2006 Investigation on the transport mechanism of bile lipids
2004 - 2005 MRP2 mediated defense against oxidative stress in liver
2004 - 2005 Role of Mitochondria as Signal Sensors in Drug-Induced Liver Injury
Takeshi Susukida, So-Ichiro Sasaki, Tomohiro Shirayanagi, Shigeki Aoki, Kousei Ito, Yoshihiro Hayakawa. Development of a novel strategy for cancer immunotherapy based on tumor immunogenicity improvement by HLA-drug interaction. CANCER RESEARCH. 2023. 83. 7
薄田健史, 青木重樹, 白柳智弘, 伊藤晃成, 早川芳弘. Development of a novel anti-cancer immunotherapy based on tumor immunogenicity improvement by the interaction between abacavir and HLA-B*57:01. 日本薬学会年会要旨集(Web). 2022. 142nd
The Japanese Society for the Research of Hepatic Cells
, 日本動物実験代替法学会
, The Japanese Society of Toxicology
, The Japanese Society for the Study of Xenobiotics
, The Pharmaceutical Society of Japan
, トランスポーター研究会
, 胆汁酸研究会
