Rchr
J-GLOBAL ID：200901050071232854   Update date: Feb. 01, 2024

Motohashi Tsutomu

モトハシ ツトム | Motohashi Tsutomu
Affiliation and department：
Gifu University Dep. of Stem Cell & Regeneration Medicine Biological Principles Division Gifu Univ. Graduate School of Medicine

About Gifu University Dep. of Stem Cell & Regeneration Medicine Biological Principles Division Gifu Univ. Graduate School of Medicine


Other affiliations (1)：
  • 医学系研究科  講師
Research field  (6)： Developmental biology ,  Cell biology ,  Molecular biology ,  Ophthalmology ,  Hematology and oncology ,  General surgery, pediatric surgery
Research keywords  (32)： Mesenchymal stem cell ,  multipotent stem cell ,  neural crest ,  mouse embryonic stem cell ,  Embryonic stem cell ,  Stem cell ,  Regenerative Medicine ,  再生医学 ,  エンドセリン3 ,  移植 ,  試験管内分化 ,  c-Kit ,  網膜色素変性症 ,  幹細胞 ,  色素細胞 ,  再生医療 ,  細胞療法 ,  網膜色素上皮 ,  レンズ ,  眼様構造 ,  網膜 ,  モノクローナル抗体 ,  M83ゲノム構造 ,  遺伝子ノックアウトマウス ,  5回膜貫通型分子M83 ,  蛍光タンパク質 ,  上皮-間葉系転換 ,  造血細胞 ,  セルソーター ,  神経堤症 ,  遺伝子改変マウス ,  転写因子Sox10
Research theme for competitive and other funds  (12)：
  • 2022 - 2025 Direct reprogramming of somatic cells by epithelial-mesenchymal transition
  • 2018 - 2023 Direct reprogramming of somatic cells by epithelial-mesenchymal transition
  • 2016 - 2019 Analysis of niche factors for melanocyte stem cells
  • 2014 - 2017 上皮-間葉系転換(EMT)モデルシステムを利用したEMTメカニズムの解明
  • 2011 - 2013 Analysis of the epithelial-mesenchymal transition (EMT) mechanism by utilizing neural crest cell generation model.
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Papers (56)：
  • Madeleine Le Coz, Zackie Aktary, Natsuki Watanabe, Ichiro Yajima, Marie Pouteaux, Nisamanee Charoenchon, Tsutomu Motohashi, Takahiro Kunisada, André Corvelo, Lionel Larue. Targeted Knockout of β-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects. Journal of Investigative Dermatology. 2021. 141. 5. 1363-1366.e9
  • Tsutomu Motohashi, Norito Kawamura, Natsuki Watanabe, Daisuke Kitagawa, Naoki Goshima, Takahiro Kunisada. Sox10 Functions as an Inducer of the Direct Conversion of Keratinocytes Into Neural Crest Cells. Stem Cells and Development. 2020. 29. 23. 1510-1519
  • Ippei Kishimoto, Takayuki Okano, Koji Nishimura, Tsutomu Motohashi, Koichi Omori. Early Development of Resident Macrophages in the Mouse Cochlea Depends on Yolk Sac Hematopoiesis. Frontiers in Neurology. 2019. 10. 1115-1115
  • Motohashi T, Kunisada T. Direct Conversion of Mouse Embryonic Fibroblasts into Neural Crest Cells. Methods in molecular biology (Clifton, N.J.). 2018
  • Tsutomu Motohashi, Masahiro Nishioka, Daisuke Kitagawa, Norito Kawamura, Natsuki Watanabe, Takanori Wakaoka, Toshihiko Kadoya, Takahiro Kunisada. Galectin-1 enhances the generation of neural crest cells. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2017. 61. 6-7. 407-413
ｍore...
MISC (5)：
Patents (1)：
Books (7)：
  • Methods in Molecular Biology, Skin Stem Cells, 2nd edn.
    Humana Press 2018
  • Current Topics in Developmental Biology, Neural Crest and Placodes
    Academic Press 2015
  • 色素細胞 第2版 基礎から臨床へ
    慶應義塾大学出版 2015
  • Methods in Molecular Biology, Skin Stem cells
    Humana Press 2013
  • Melanoblasts as Multipotent Cells in Murine Skin.
    Methods in Molecular Biology 2013
ｍore...
Lectures and oral presentations  (17)：
  • マウスES細胞の色素細胞分化誘導系を用いた神経堤細胞解析の試み
    (第三回幹細胞シンポジウム/兵庫、淡路夢舞台 2011)
  • Multipotent cell fates of melanocyte precursors isolated from embryonic and neonatal skin.
    (XXth International Pigment Cell Conference & Vth International Melanoma Research Congress 2008)
  • Multipotent cell fates of melanocyte precursors isolated from embryonic and neonatal skin.
    (XXth International Pigment Cell Conference & Vth International Melanoma Research Congress 2008)
  • Derivation of neural crest-like cells from mouse embryonic stem cells.
    (Keystone Symposia 2007)
  • Derivation of neural crest-like cells from mouse embryonic stem cells.
    (Keystone Symposia 2007)
ｍore...
Professional career (2)：
  • (BLANK) (University of Tsukuba)
  • 医科学修士 (筑波大学)
Work history (5)：
  • 2021/04 - 現在 岐阜大学 大学院医学系研究科 生命原理学講座 再生機能医学分野 講師
  • 2008/12 - 2021/03 Gifu University Graduate School of Medicine
  • 2001/06 - 2008/11 Gifu University Graduate School of Medicine
  • 2001/04/01 - 2001/05/31 科学技術振興事業団
  • 1990/04/01 - 1995/03/31 テルモ株式会社 開発研究所
Awards (1)：
  • 2010/05/15 - (社)岐阜医学研究協議会 第22回岐阜医学奨励賞
Association Membership(s) (4)：
The International Society for Stem Cell Research ,  The Japanese Society for Regenerative Medicine ,  The Japanese Society of Developmental Biologists ,  Molecular Biology Society of Japan
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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