Rchr
J-GLOBAL ID：200901050195647262   Update date: Jan. 30, 2024

Hirai Hideyo

ヒライ ヒデヨ | Hirai Hideyo
Affiliation and department：
東京薬科大学 生命科学部・生命科学科・幹細胞制御学研究室

About 東京薬科大学 生命科学部・生命科学科・幹細胞制御学研究室


Job title： 教授
Research field  (2)： Hematology and oncology ,  Immunology
Research keywords  (6)： Regenerative medicine ,  Cell Therapy ,  Transcription factor ,  Stress hematopoiesis ,  Myeloid hematopoiesis ,  Hematopoietic stem cell
Research theme for competitive and other funds  (22)：
  • 2021 - 2024 形質転換時の代謝リプログラミングにおけるC/EBPβの機能解明と治療戦略の開発
  • 2021 - 2024 慢性炎症下の造血幹細胞制御におけるストレス造血制御因子C/EBPβの機能解明
  • 2021 - 2023 Elucidation of mechanisms involved in differentiation and functions of a novel subset of monocytes
  • 2019 - 2023 SOCS3が制御する高脂肪誘発性myeloid hematopoiesisの機序
  • 2018 - 2022 Stress hematopoiesis regualted by C/EBPbeta transcription factor
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Papers (139)：
  • Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto, et al. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Reports. 2023. 42. 3. 112165-112165
  • Naoka Kamio, Asumi Yokota, Yuichi Tokuda, Chie Ogasawara, Masakazu Nakano, Miki Nagao, Kei Tashiro, Taira Maekawa, Nobuyuki Onai, Hideyo Hirai. A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties. Journal of immunology (Baltimore, Md. : 1950). 2022. 209. 3. 498-509
  • Kazuharu Kamachi, Hiroshi Ureshino, Tatsuro Watanabe, Nao Yoshida, Yuta Yamamoto, Yuki Kurahashi, Yuki Fukuda-Kurahashi, Yoshihiro Hayashi, Hideyo Hirai, Satoshi Yamashita, et al. Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia. Cancer letters. 2022. 526. 273-283
  • Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, et al. Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency. iScience. 2021. 24. 10. 103117-103117
  • 濱野 京子, 万木 紀美子, 秦 浩一郎, 菱田 理恵, 澁谷 江里香, 新井 康之, 上本 伸二, 平位 秀世. リンパ球クロスマッチとHLA抗体検査結果の乖離症例における補体活性の検討. MHC: Major Histocompatibility Complex. 2021. 28. 2Suppl. 99-99
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MISC (248)：
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Patents (2)：
  • 抗ヒトCCR1モノクローナル抗体
  • 抗ヒトccr1モノクローナル抗体
Books (8)：
  • 緊急時好中球造血に必須の転写因子C/EBPβによる造血幹細胞の分化増殖制御
    日本血液学会 2018
  • CML幹細胞における転写因子C/EBPβの役割.
    科学評論社 2017
  • 白血病学(上)
    日本臨床社 2016
  • 造血器腫瘍アトラス(改訂第5版)
    日本医事新報社 2016
  • 分子細胞生物学辞典第二版(付録)
    東京化学同人 2008
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Lectures and oral presentations  (10)：
  • C/EBP転写因子による好中球造血の制御機構と疾患
    (第4回NIIGATA Hematology Seminar 2018)
  • C/EBPβ isoforms sequentially regulate proliferation and differentiation of regenerating hematopoietic stem/progenitor cells.
    (Twelfth International Workshop On Molecular Aspects Of Myeloid Stem Cell Development And Leukemia. (2018 Myeloid Stem Cell Development & Leukemia Conference) 2018)
  • Regulation of hematopoietic stem cells by C/EBPβ, a transcription factor required for emergency granulopoiesis.
    (The 79th Annual Meeting of the Japanese Society of Hematology, Symposium 6: “New world of innate immunity:Unexpected ontogeny and surprising functions” 2017)
  • 骨髄球系転写因子C/EBPβによるストレス造血制御
    (第5回北海道感染免疫アカデミー 2017)
  • Chronic myeloid leukemia as a mode of ‘emergency granulopoiesis’ hijacked by BCR-ABL fusion protein
    (2017)
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Education (2)：
  • 1995 - 1999 Kyoto Prefectural University of Medicine
  • - 1991 Kyoto Prefectural University of Medicine
Professional career (1)：
  • Doctor of Medicine (Kyoto Prefectural University of Medicine)
Work history (8)：
  • 2020/07 - 現在 Tokyo University of Pharmacy and Life Sciences
  • 2019/08 - 2020/06 Kyoto University
  • 2010/04 - 2019/07 Kyoto University
  • 2009/04 - 2010/03 Kyoto University
  • 2007/04 - 2009/03 Kyoto Prefectural University of Medicine
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Association Membership(s) (9)：
日本感染症学会 ,  日本内科学会 ,  日本免疫学会 ,  日本血液学会 ,  International Society for Experimental Hematology ,  American Society of Hematology ,  日本がん分子標的治療学会 ,  日本輸血細胞治療学会 ,  日本癌学会
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