Higashi Michiyo

ヒガシミチヨ | Higashi Michiyo

Affiliation and department：
Job title： Lecturer,Lecturer

Research field (1)： Human pathology

Research keywords (4)：ムチン肝内胆管癌膵癌胆嚢癌 , neoplasm , mucin , Pancreatobiliary tract

Research theme for competitive and other funds (21)：

2021 - 2024 CEST画像による膵癌の分子イメージングとこれを用いた非造影膵MR診断法の確立
2021 - 2024 膵胆管系腫瘍の早期診断と治療の為のバイオマーカー探索
2021 - 2024 Construction of DNA Methylation Markers for liqid biopsy of Pancreatic Cancer.
2020 - 2023 Genetic assessments to detect patients requiring prophylactic total pancreatectomy for the prevention of pancreatic cancer.
2018 - 2021 A fundamental study for construction of bile duct cancer early diagnosis method by DNA methylation analysis.

2018 - 2021 Establishment of early diagnosis and treatment effect prediction method for pancreatobiliary neoplasm

2018 - 2021 Basic research for the development of novel aromatase inhibitors against breast cancer

2015 - 2018 Blood oxygenation level-dependent contrast magnetic resonance imaging for prediction of overall survival in patients with pancreatic adenocarcinoma after chemoradiotherapy

2015 - 2018 Attempt to establishment of early diagnosis and prediction of therapeutic response in pancreatobiliary neoplasms

2014 - 2017 Experimental study of selective portal vein embolization for nonalcoholic steatohepatitis in rabbit model

2014 - 2017 膵液を用いた新規メチル化解析法による膵癌の早期診断予測法の構築

2012 - 2015 Establishment of early diagnosis of pabcreatobiliary neoplasm

2011 - 2014 Establishment of early diagnosis system of pancreatobiliary carcinomas by the application of mucin expression profiles

2009 - 2011 Investigation of prognostic factor in pancreatobiliary neoplasm

2008 - 2010 Mucin gene expression mechanism related to a new classification of pancreatobiliary neoplasms

2008 - 2009 ヒト癌のリスク評価に普遍的に関連するムチン抗原の遺伝子発現機構の解明

2006 - 2007 ヒト腺癌のリスク評価に普遍的に関連するムチン抗原の特定

2005 - 2005 膵胆管系癌患者のリスクに関連するムチン抗原の特定とその遺伝子発現機構の解明

2000 - 2002 Re-classification of pancreatobiliary tumors by mucin expression profile - An application to the operative indication -

ヒト癌の産生するムチンと癌の生物学的悪性度との関連性

Relationship of biological behavior and mucin expression in human cancer

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Papers (119)：

切田ゆかり, 北薗育美, 亀澤雅, 古家淳行, 窪田恵美, 霧島茉莉, 村上未樹, 田崎貴嗣, 簗詰伸太郎, 東美智代, et al. 子宮腟部液状化検体細胞診(LBC)に出現した卵巣原発yolk sac tumorの一例. 日本臨床細胞学会雑誌. 2023. 62. Suppl.2. 508-508
Mari Kirishima, Toshiaki Akahane, Tomoko Takajo, Nayuta Higa, Hajime Yonezawa, Hiroyuki Uchida, Kiyohisa Kamimura, Ryosuke Hanaya, Koji Yoshimoto, Michiyo Higashi, et al. A case of glioblastoma harboring non-amplified epidermal growth factor receptor variant III: Critical molecular detection using RNA-based panel analysis. Pathology, research and practice. 2023. 248. 154712-154712
古家淳行, 亀澤雅, 窪田恵美, 岩切かおり, 霧島茉莉, 田崎貴嗣, 北薗育美, 東美智代, 谷本昭英. 右臀部に発生した類上皮肉腫の一例. 日本臨床細胞学会九州連合会雑誌. 2023. 54. 83-86
Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa, Akihide Tanimoto. MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer. BMC cancer. 2023. 23. 1. 424-424
Hiromichi Iwaya, Akihide Tanimoto, Koshiro Toyodome, Issei Kojima, Makoto Hinokuchi, Shiroh Tanoue, Shinichi Hashimoto, Machiko Kawahira, Shiho Arima, Shuji Kanmura, et al. Next-Generation Sequencing Analysis of Pancreatic Cancer Using Residual Liquid Cytology Specimens from Endoscopic Ultrasound-Guided Fine-Needle Biopsy: A Prospective Comparative Study with Tissue Specimens. Diagnostics (Basel, Switzerland). 2023. 13. 6

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MISC (77)：

横山勢也, 東美智代, 谷本昭英. ムチン遺伝子のメチル化情報を用いた機械学習による膵癌摘出術後の予後評価(Prediction of prognosis with PDAC by Machine learning models using mucin genes methylation status). 日本病理学会会誌. 2019. 108. 1. 321-322
横山勢也, 東美智代, 谷本昭英. PDAC摘出術後におけるムチン遺伝子のメチル化解析を用いた予後予測法の構築(Construction of prognosis prediction for pancreatic ductal adenocarcinomas by methylation analysis of mucins promoters). 日本癌学会総会記事. 2018. 77回. 552-552
横山勢也, 東美智代, 谷本昭英, 米澤傑. 【肝胆膵疾患のエピジェネティクスを学ぶ】膵疾患のエピジェネティクス膵癌におけるメチル化によるムチン発現調節. 肝・胆・膵. 2018. 76. 5. 945-950
横山勢也, 東美智代, 谷本昭英, 米澤傑. 【肝胆膵疾患のエピジェネティクスを学ぶ】膵疾患のエピジェネティクス膵癌におけるメチル化によるムチン発現調節. 肝・胆・膵. 2018. 76. 5. 945-950
平木翼, 霧島茉莉, 後藤優子, 飛田陽, 東美智代, 野元三治, 谷本昭英. 切除心臓粘液腫におけるIgG4陽性形質細胞浸潤と臨床病理学的特徴との比較検討. 日本病理学会会誌. 2018. 107. 1. 499-499

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Education (2)：

- 1999 Kagoshima University
- 1993 Kagoshima University Faculty of Medicine

Professional career (1)：

博士(医学) (鹿児島大学)

Work history (1)：

2003 - - 鹿児島大学医学部助手

Committee career (1)：

日本病理学会評議員

Association Membership(s) (4)：

肝胆膵外科学会 , 日本胆道学会 , 日本癌学会 , 日本病理学会

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