Rchr
J-GLOBAL ID：200901050527499661   Update date: Jan. 31, 2024

nukina nobuyuki

nukina nobuyuki
Affiliation and department：
Doshisha University Laboratory of Structural Neuropathology

About Doshisha University Laboratory of Structural Neuropathology


Job title： Professor
Homepage URL  (2)： https://brainscience.doshisha.ac.jp/introduction/pat/ca.html ,  https://brainscience.doshisha.ac.jp/en/introduction/pat/ca.html
Research field  (1)： Neurology
Research keywords  (27)： 構造生物学 ,  神経伝達物質 ,  GABA ,  Huntington disease ,  aggresome ,  ベ-タ蛋白 ,  Abeta蛋白 ,  神経原線維変化 ,  beta4 subunit ,  glial cytoplasmic inclusion ,  CAGリピート ,  CAGリピート病 ,  病態脳 ,  老年痴呆 ,  X線小角散乱 ,  脳科学 ,  多系統萎縮症 ,  ポリグルタミン病 ,  凝集体 ,  ミオグロビン ,  DRPLA ,  老人斑 ,  アルツハイマ-病 ,  ユビキチン ,  アミロイド ,  ポリグルタミン ,  ハンチントン病
Research theme for competitive and other funds  (39)：
  • 2020 - 2023 量子ドットによるパーキンソン病態変化の可視化と治療介入に役立つ新規生体指標の探索
  • 2018 - 2022 Analysis of chromatin structure in degenerating neurons
  • 2017 - 2022 Comprehensive analysis of unmyelinated fibers in central nervous system
  • 2016 - 2020 Early Alzheimer-like pathogenic events in endocytic membrane traffic in Down Syndrome iPSC-derived neurons
  • 2015 - 2019 Molecular analysis of a novel ER stress response in neurons
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Papers (161)：
  • Tomoyuki Yamanaka, Masaru Kurosawa, Aya Yoshida, Tomomi Shimogori, Akiko Hiyama, Sankar N Maity, Nobutaka Hattori, Hideaki Matsui, Nobuyuki Nukina. The Transcription factor NF-YA is Crucial for Neural Progenitor Maintenance during Brain Development. The Journal of biological chemistry. 2024. 105629-105629
  • Ayami Okuzumi, Taku Hatano, Gen Matsumoto, Shuko Nojiri, Shin-Ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Soichiro Kakuta, Akihide Kondo, Takeshi Fukuhara, et al. Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nature medicine. 2023. 29. 6. 1448-1455
  • 奥住 文美, 波田野 琢, 松本 弦, 貫名 信行, 服部 信孝. IP/RT-QuICによるシヌクレノパチー疾患特異的血液アルファシヌクレインシードの検出. パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2022. 16回. 76-76
  • Yukio Imamura, Ayami Okuzumi, Saki Yoshinaga, Akiko Hiyama, Yoshiaki Furukawa, Tomohiro Miyasaka, Nobutaka Hattori, Nobuyuki Nukina. Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission. Communications biology. 2022. 5. 1. 636-636
  • Hongsun Park, Tomoyuki Yamanaka, Nobuyuki Nukina. Proteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions. Scientific reports. 2022. 12. 1. 4347-4347
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MISC (58)：
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Professional career (1)：
  • MD,PhD
Work history (10)：
  • 2015/04 - 現在 Doshisha University Graduate School of Brain Science
  • 2012/10 - 2015/03 Juntendo University
  • 1997/10 - 2012/10 Lab. for Structural Neuropathology, RIKEN Brain Science Institute Head
  • 1985/09 - 1998/07 Harvard Medical School (Brigham and Women’s Hospital, Center for Neurologic Diseases) Research Associate
  • 1997/04 - 1997/09 The University of Tokyo Graduate School of Medicine
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