Rchr

J-GLOBAL ID：200901050777382727 Update date: Feb. 01, 2024

Goitsuka Ryo

ゴイツカリヨウ | Goitsuka Ryo

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.ribs.tus.ac.jp/index.php/institute/labforres/goitsukalab/

Research field (3)： Veterinary medicine , Zoological sciences , Laboratory animal science

Research keywords (1)： Immunology, Allergy, Development

Research theme for competitive and other funds (35)：

2021 - 2024 Chronological impact of fetal immune memory on visceral adipose tissue inflammation
2016 - 2019 Research on spleen microenvironment supporting extramedullary hematopoiesis and its application to the expansion of hematopoietic stem cells
2015 - 2017 転写因子によるリプログラミングを軸とした脾臓微小環境形成機構の解明
2014 - 2016 Spleen mesenchymal cells incorporated into the pancreatic microenvironment
2013 - 2016 Phenotypical and functional characterization of mesenchymal stem cells in the spleen

2013 - 2015 免疫・造血ニッチとしての脾臓微小環境の形成ならびに再生の制御機構

2012 - 2014 The control mechanism of B cells activation due to pKnox1 homeodomain transcription factor

2011 - 2014 Molecular basis of myeloid leukemogenesis

2011 - 2013 Meis1 regulates epidermal stem cells and is required for skin tumorigenesis

2011 - 2012 Generation of artificial thymus using trans-differentiation potentials between skin and thymic epithelial cells

2009 - 2011 Transcription factor network involved in maintenance and regeneration of epithelial progenitor cells in the thymus

2009 - 2010 分化抑制解除による肥満細胞性白血病幹細胞の同定とその発生・維持機構の解明

2006 - 2007 Pathophysiological roles of basophils and mast cells in allergic inflammations

2005 - 2006 NK細胞活性化制御による腫瘍監視の増強

2004 - 2004 ナチュラルキラー細胞活性化制御に基づいた腫瘍抵抗性の増強

2004 - 2004 NK細胞活性化制御による腫瘍監視の増強

2002 - 2004 Corss-talk of signals between immunoreceptors and cytokine receptors for development of allergy

2000 - 2002 Anti-allergic therapy targeting to a mast cell-specific signaling protein

2001 - 2001 高頻度で相同組換えを起こすB細胞株を用いた多重遺伝子ファミリーの機能解析

1999 - 2001 Regulation of development of type I allergy by the signal transducer specific for the high-affinity IgE receptor

1998 - 2000 アレルギー炎症における好塩基球と肥満細胞の病態生理学的役割の解明

1998 - 2000 Pathophysiological roles of basophils and mast cells in allergic reactions

1998 - 1999 Notch関連分子によるニワトリ造血幹細胞自己復製制御機構

1996 - 1998 Development of molecular probes for genome-wide genotyping by restriction landmark genomic scanning (RLGS) method.

1992 - 1993 Clinical pathobiological studies on Sarcocystosis

1992 - 1993 Aberration of oncogenes and tumor suppressor genes in hematopocetic tumors in animals

1991 - 1993 Studies on the mechanisms of persistent infection and reactivation of animal viruses

1992 - 1992 ニワトリの免疫グロブリン抗原レセプター複合体を形成する分子の遺伝子クローニング

1991 - 1991 家畜の好酸球増多症におけるインターロイキン5の動態に関する研究

1990 - 1991 Basic and Clinical Studies on abnormal expression of cytokine receptors in animals

1990 - 1991 Clinico-Pathological Studies on Canine Babesiosis

1990 - 1990 ネコのインターロイキン2(1L-2)レセプターに関する研究

1989 - 1989 ウシおよびネコの白血病細胞の産生するサイトカインに関する研究

1988 - 1989 Basic and clinical studies on the immunopathogenesis of viral infection

1988 - 1989 Studies on canine erythrocyte insulin receptors

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Papers (68)：

Atsuya Sawabe, Shogo Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu. The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor. Journal of leukocyte biology. 2024
Yuki Kugii, Yui Kuroki, Yasushi Hara, Ryo Goitsuka, Naoko Nakano. Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development. The Journal of Immunology. 2023
Yotaroh Sato, Miho Tsuyusaki, Hiromi Takahashi-Iwanaga, Rena Fujisawa, Atsushi Masamune, Shin Hamada, Ryotaro Matsumoto, Yu Tanaka, Yoichi Kakuta, Yumi Yamaguchi-Kabata, et al. Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice. Frontiers in molecular biosciences. 2022. 9. 1040237-1040237
Takuo Katsumoto, Yoko Ogawara, Kazutsune Yamagata, Yukiko Aikawa, Ryo Goitsuka, Takuro Nakamura, Issay Kitabayashi. MOZ is critical for the development of MOZ/MLL-fusion-induced leukemia through regulation of Hoxa9/Meis1 expression. Blood Advances. 2022. 6. 19. 5527-5537
Morito Kurata, Iichiro Onishi, Tomoko Takahara, Yukari Yamazaki, Sachiko Ishibashi, Ryo Goitsuka, Daisuke Kitamura, Junko Takita, Yasuhide Hayashi, David A Largaesapda, et al. C/EBPβ induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations. Cancer science. 2021

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MISC (30)：

小田朗永, 後飯塚僚. 成体脾臓における髄外造血ニッチとその構成要素. 医学のあゆみ. 2018. 264. 3. 258-259
鯉沼真吾, 野村理子, 小島拓哉, 根岸亮太, 竹内公平, 瀬木恵里, 田, 後飯塚僚, 古市貞一, 岩倉洋一郎, et al. 膜輸送を介して突起伸展を促進するRhoファミリーGタンパク質TC10は末梢神経の軸索再生に働く. 生命科学系学会合同年次大会. 2017. 2017. 1205-1206
Y. Tashiro, A. Murakami, T. Shimizu, R. Goitsuka, H. Kishimoto, T. Azuma. High-affinity IgM(+) memory B cells are deficient in terminal differentiation potential to secrete IgM antibodies by restimulation with (4-hydroxy-3-nitrophenyl) acetyl-chicken gamma-globulin. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 1147-1147
後飯塚僚. 間葉系ストローマ細胞による造血制御とその応用. 家畜感染症学会誌. 2016. 5. 2. 69-74
奥村和弘, 佐藤美穂, 斎藤慈, 大澤光次郎, 岩間厚志, 廣瀬哲史, 木南凌, 後飯塚僚, 中村卓郎, 若林雄一. Meis 1遺伝子の皮膚化学発がんにおける機能を明らかにする(Targeted disruption of Meis1 demonstrated a role for epidermal stem cells in skin carcinogenesis). 日本癌学会総会記事. 2012. 71回. 246-246

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Patents (1)：

観察方法、測定方法、解析方法、定量方法、およびキット

Books (4)：

獣医臨床のための免疫学
学窓社 2016 ISBN:9784873627533
アレルギー疾患イラストレイテッド第2版
メディカルレビュー社 2010
BASH/SLAP-76ファミリーアダプター分子MISTによる免疫細胞機能制御
中外医学社「Annual Review 免疫 2003」 2003
アダプター分子MISTによる免疫細胞機能の制御
中山書店「免疫 2003」 2003

Lectures and oral presentations (108)：

Two distinct subsets of embryo-derived B cells in adulthood.
(第51回日本免疫学会学術集会 2022)
Embryo-derived innate-like B cells expressing the J-chain in cardiac fat-associated lymphoid clusters.
(第51回日本免疫学会学術集会 2022)
B cell antigen receptors expressed on embryo-derived innate-like B cells
(第51回日本免疫学会学術集会 2022)
口腔扁平上皮癌におけるFOXA1の発現低下は腫瘍成長とxCT依存性を促進する。
(第45回日本分子生物学会年会 2022)
粘膜型マスト細胞特異的プロテアーゼMcpt1, 2の遺伝子制御機構解析とMcpt2-iCreマウスの作出
(第45回日本分子生物学会年会 2022)

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Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (5)：

2007/04 - Division of Development and Aging, Research Institute for Biological Sciences, Tokyo University of Sciences Professor
2006 - 2007 Division of Development and Aging, Research Institute for Biological Sciences, Tokyo University of Sciences Associate Professor
1997 - 2006 Division of Molecular biology, Research Institute for Biological Sciences, Tokyo University of Sciences Associate Professor
1995 - 1998 Japan Science and Technology Coorporation, Researcher
1987 - 1995 The University of Tokyo, Research Assistant

Committee career (19)：

2022/04/01 - 2024/03/31 日本獣医学会評議委員
2021/04/01 - 2023/03/31 Kyoto T cell Conference 運営委員
2020/04/01 - 2022/03/31 日本獣医学会評議委員
2019/04/01 - 2021/03/31 Kyoto T cell Conference 運営委員
2018/04/01 - 2020/03/31 日本獣医学会評議委員

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Awards (1)：

2010/10/29 - 科学研究費補助金第一段審査委員表彰

Association Membership(s) (2)：

日本獣医学会 , Kyoto T cell Conference

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