Rchr
J-GLOBAL ID：200901050966510450   Update date: Jan. 30, 2024

Sugahara Mitsuaki

スガハラ ミツアキ | Sugahara Mitsuaki
Research field  (1)： Environmental load/risk assessment
Research theme for competitive and other funds  (14)：
  • 2001 - 2002 高度好熱菌MutM蛋白質を用いた活性酸素障害DNA塩基除去修復機構の解析
  • 2001 - 構造ゲノム科学に対応したX線結晶構造解析を大規模かつ迅速に行うための全自動化に向けたハードおよびソフトの概念設計および新しい技術の開発
  • 2001 - 蛋白質などの生体高分子のX線結晶学を手法とし、3次元立体構造に基づき蛋白質の機能を解明する構造生物学研究
  • 2001 - Development of new technique and conceptual design of hardware and software toward full-automation to execute the determination of x-ray crystal structure in large and rapidly corresponding to the Structural Genomics.
  • 2001 - Structural Biology Research which reveals the function of proteins based on their 3D structures with X-ray crystallograpy of biomacromolecules such as a protein.
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Papers (26)：
  • Tosha T, Nomura T, Nishida T, Saeki N, Okubayashi K, Yamagiwa R, Sugahara M, Nakane T, Yamashita K, Hirata K, et al. Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate. Nature communications. 2017. 8. 1. 1585-1585
  • Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, et al. 5B35: Serial Femtosecond Crystallography (SFX) of Ground State Bacteriorhodopsin Crystallized from Bicelles Determined Using 7-keV X-ray Free Electron Laser (XFEL) at SACLA. Worldwide Protein Data Bank. 2016
  • Nakane T, Song C, Suzuki M, Nango E, Kobayashi J, Masuda T, Inoue S, Mizohata E, Nakatsu T, Tanaka T, et al. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography. Acta crystallographica. Section D, Biological crystallography. 2015. 71. Pt 12. 2519-2525
  • Yamashita K, Pan D, Okuda T, Sugahara M, Kodan A, Yamaguchi T, Murai T, Gomi K, Kajiyama N, Mizohata E, et al. An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography. Scientific reports. 2015. 5. 14017
  • Yamashita K, Pan D, Okuda T, Sugahara M, Kodan A, Yamaguchi T, Murai T, Gomi K, Kajiyama N, Mizohata E, et al. Luciferin-regenerating enzyme solved by SIRAS using XFEL (refined against Hg derivative data). Worldwide Protein Data Bank. 2015
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MISC (18)：
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Patents (2)：
  • タンパク質等の結晶化方法及び装置
  • METHOD AND APPARATUS FOR CRYSTALLIZATION OF PROTEINS
Works (2)：
  • 大規模蛋白質立体構造解析全自動結晶化観察システムの開発等
    2002 -
  • Development of full-automatic protein crystallization and observation system for the determination of protein three dimensional structure
    2002 -
Education (2)：
  • - 2000 Osaka University
  • - 2000 Osaka University Graduate School, Division of Science bioscience
Professional career (1)：
  • Ph.D
Work history (8)：
  • 2003 - 理化学研究所ハイスループットファクトリー チームリーダー(兼任)
  • 2003 - RIKEN Highthroughput
  • 2002 - 理化学研究所構造生物物理研究室 研究員
  • 2002 - RIKEN Structural Biophysics Lab. Research Scientist
  • 2000 - 理化学研究所構造生物物理研究室 基礎科学特別研究員
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Awards (2)：
  • 2000 - JB論文賞
  • 2000 - JB Award
Association Membership(s) (8)：
日本放射光学会 ,  日本生化学会 ,  日本分子生物学会 ,  日本結晶学会 ,  The Japanese Society for Synchrotron Radiation Research ,  the Japanese Biochemical Society ,  The Molecular Biology Society of Japan ,  The Crystallographic Society of Japan
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