Rchr
J-GLOBAL ID：200901051069010239   Update date: Apr. 21, 2024

Gotoh Noriko

ゴトウ ノリコ | Gotoh Noriko
Affiliation and department：
Kanazawa University Cancer Research Institute

About Kanazawa University Cancer Research Institute


Job title： Associate Professor
Research field  (5)： Pathobiochemistry ,  Tumor biology ,  Developmental biology ,  Cell biology ,  Molecular biology
Research keywords  (6)： Stem cell biology ,  Tumor molecular biology ,  発生生物学 ,  細胞生物学 ,  分子生物学 ,  Developmental Biology
Research theme for competitive and other funds  (33)：
  • 2022 - 2026 脈管内がん幹細胞の胚シグナル分子による微小環境形成機構とそれを標的にした治療戦略
  • 2021 - 2024 乳がんゲノム遺伝子変異の不均一性及び幹細胞階層性の1細胞レベル統合解明
  • 2020 - 2022 幹細胞分裂過程リアルタイムイメージングによる細胞社会ダイバーシティ獲得機構の解明
  • 2019 - 2022 Elucidation of molecular mechanism of cancer stem cell niche at the very early stage aiming at cancer prevention
  • 2018 - 2021 Integrative analysis of genetical mutations and heterogeneity based on stemness in breast cancer cells
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Papers (150)：
  • Noritaka Tanaka, Hikari Okada, Kiyoshi Yamaguchi, Masahide Seki, Daisuke Matsubara, Noriko Gotoh, Yutaka Suzuki, Yoichi Furukawa, Taro Yamashita, Jun-Ichiro Inoue, et al. Mint3-depletion-induced energy stress sensitizes triple-negative breast cancer to chemotherapy via HSF1 inactivation. Cell death & disease. 2023. 14. 12. 815-815
  • Li M, Nishimura T, Takeuchi Y, Hongu T, Wang Y, Shiokawa D, Wang K, Hirose H, Sasahara A, Yano M, et al. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. Journal of Clinical Investigation. 2023
  • Yuming Wang, Tsunaki Hongu, Tatsunori Nishimura, Yasuto Takeuchi, Hiroshi Takano, Takiko Daikoku, Ryoji Yao, Noriko Gotoh. Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy. Biochemical and biophysical research communications. 2023. 674. 183-189
  • Carlos E. M. Relvas, Asuka Nakata, Guoan Chen, David G. Beer, Noriko Gotoh, Andre Fujita. A model-based clustering algorithm with covariates adjustment and its application to lung cancer stratification. Journal of Bioinformatics and Computational Biology. 2023. 21. 04
  • Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, Yukino Machida, Keitaro Shibata, Norihito Shintani, Takashi Kohno, Noriko Gotoh, Chiaki Takahashi, Atsushi Hirao, et al. Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line. Cell death & disease. 2023. 14. 4. 241-241
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MISC (38)：
  • 本宮 綱記, 後藤 典子. テネイシンCはマクロファージと肺血管内皮細胞の連続的な活性化を介して肺血管性転移ニッチの形成を誘導する(TNC triggers sequential activation of macrophages and endothelial cells to generate a metastatic vascular niche in lung). 日本癌学会総会記事. 2022. 81回. MS1-4
  • Yasuto Takeuchi, Natsuko Kimura, Takahiko Murayama, Yukino Machida, Daisuke Iejima, Tatsunori Nishimura, Yuming Wang, Mizuki Yamamoto, Naoki Itano, Junichiro Inoue, et al. FRS2b fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis. CANCER SCIENCE. 2022. 113. 994-994
  • Li Mengjiao, Tatsunori Nishimura, Daisuke Shiokawa, Shimamura Teppei, Asako Sasahara, Masao Yano, Satoko Ishikawa, Tetsuo Ota, Keiichiro Tada, Koji Okamoto, et al. Single-cell RNAseq identifies subpopulations of drug resistant cancer stem-like cells in patient-derived breast cancer. CANCER SCIENCE. 2022. 113. 1325-1325
  • Mengjiao Li, Tatsunori Nishimura, Asako Sasahara, Masao Yano, Satoko Ishikawa, Tetsuo Ohta, Kei-ichiro Tada, Daisuke Shiokawa, Koji Okamoto, Noriko Gotoh. Single cell analysis revealed heterogeneity among patient-derived breast cancer stem-like cells. CANCER SCIENCE. 2021. 112. 696-696
  • Tatsunori Nishimura, Mengjiao Li, Daisuke Shiokawa, Teppei Shimamura, Asako Sasahara, Masao Yano, Satoko Ishikawa, Tetsuo Ohta, Kei-ichiro Tada, Kim Seong-Jin, et al. Identification of subpopulations in patient-derived breast cancer stem-like cells by using RNA sequencing. CANCER SCIENCE. 2021. 112. 173-173
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Patents (17)：
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Books (37)：
  • 乳がん幹細胞を再現するバイオロジーとそれに関わるシグナル伝達経路
    実験医学別冊 がん微小環境に1細胞レベルで挑む(羊土社) 2021
  • 「乳腺のオルガノイドによるマイ・メディシン」-がん幹細胞研究の立場から
    医学のあゆみ (医歯薬出版株式会社) 2021
  • 微小環境と治療抵抗性メカニズム in CANCER BOARD of the BREAST
    2020
  • がん幹細胞とそのニッチ in 医学のあゆみ
    医学のあゆみ (医歯薬出版株式会社) 2020
  • がん幹細胞とその微小環境および治療への展望
    羊土社 2020
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Lectures and oral presentations  (88)：
  • 一炭素代謝酵素が制御する腫瘍免疫におけるポリアミン代謝
    (第46回日本分子生物学会 シンポジウム 「ポリアミン研究の最前線」 2023)
  • FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters
    (2023)
  • 第13回シグナルネットワーク研究会
    (第13回シグナルネットワーク研究会 2023)
  • がん間質細胞CAF由来因子によるがん幹細胞の浸潤、骨転移
    (日本患者由来がんモデル学会学術集会2022シンポジウム 「がん三次元培養研究の新展開」 2023)
  • Heterogenous breast cancer stem cells sustain in primary and metastatic cancer stem cell niches
    (The 41st Sapporo International Cancer Symposium 2023)
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Works (6)：
  • FGF、ニューロトロフィンの関与する発生や疾病へのシグナリングの研究
    2001 -
  • Signal transduction pathways through FGF and neurotrophin for development and disease
    2001 -
  • アダプター分子Shcを介するシグナル伝達研究
    1993 - 1998
  • Study of Signal transduction through Shc adaptor protein
    1993 - 1998
  • EGF受容体を介するシグナル伝達研究
    1992 - 1998
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Education (4)：
  • - 1993 The University of Tokyo
  • - 1993 The University of Tokyo Graduate School, Division of Medical Sciences
  • - 1989 Kanazawa University
  • - 1989 Kanazawa University Faculty of Medicine
Professional career (1)：
  • Doctor (The University of Tokyo)
Work history (12)：
  • 2013/04 - 現在 Cancer Research Institute, Kanazawa University Division of Cancer Cell Biology Professor
  • 2007/04 - 2013/03 Institute of Medical Science, The University of Tokyo Division of Systems Medical Technology Associate Professor
  • 2005/07 - 2007/03 Institute of Medical Science, The University of Tokyo Division of Genetics Associate Professor
  • 2002/07 - 2005/03 Institute of Medical Science, The University of Tokyo Division of Genetics Lecturer
  • 2001 - 2002 Josyu, Division of Genetics, Institute of Medical Science, University of Tokyo
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Awards (1)：
  • 2023/04 - 文部科学省 文部科学大臣表彰科学技術賞研究部門 がん幹細胞が維持される微小環境の仕組み解明の研究
Association Membership(s) (7)：
American Association of Cancer Research ,  日本内科学会 ,  日本血液学会 ,  日本分子生物学会 ,  日本癌学会 ,  JAPAN CYTOMETRY SOCIETY ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
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