Rchr
J-GLOBAL ID：200901051146968505   Update date: Apr. 04, 2024

Shibata Atsushi

シバタ アツシ | Shibata Atsushi
Affiliation and department：
Keio University

About Keio University


Job title： Professor
Other affiliations (1)：
Homepage URL  (2)： https://shibataxlab.com/ ,  https://shibataxlab.com/english/
Research field  (6)： Environmental effects of chemicals ,  Environmental effects of radiation ,  Radiology ,  Pathobiochemistry ,  Molecular biology ,  Genetics
Research keywords  (14)： DNA修復 ,  DNA損傷 ,  がん治療 ,  化学放射線治療 ,  がん免疫治療(PD-L1, HLA, Neoantigen) ,  クロマチン ,  幹細胞 ,  遺伝子発現調節 ,  ゲノム医科学 ,  ゲノム安定性 ,  発がん ,  創薬・核酸医薬 ,  超高解像度蛍光顕微鏡 ,  蛍光イメージング解析
Research theme for competitive and other funds  (41)：
  • 2023 - 2026 人工ウィルスにより抗腫瘍免疫を起動する新規免疫療法の開発
  • 2022 - 2025 ヒト遺伝子破壊株を用いた高LET線誘発DSBの修復とゲノム情報への影響の解析
  • 2021 - 2025 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究
  • 2021 - 2023 非自己核酸が誘発するHLA提示およびISGs発現誘導を介した免疫惹起機構の研究
  • 2020 - 2022 遺伝子領域間に引き起こされる転写共役型染色体転座経路の解明
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Papers (97)：
  • Kohei Okada, Hiro Sato, Takuya Kumazawa, Yasumasa Mori, Tiara Bunga Mayang Permata, Yuki Uchihara, Shin-ei Noda, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, et al. Calreticulin Upregulation in Cervical Cancer Tissues From Patients After 10 Gy Radiation Therapy. Advances in Radiation Oncology. 2023. 8. 3. 101159-101159
  • Takahiro Oike, Sangeeta Kakoti, Makoto Sakai, Akihiko Matsumura, Tatsuya Ohno, Atsushi Shibata. Analysis of the relationship between LET, γH2AX foci volume and cell killing effect of carbon ions using high-resolution imaging technology. Journal of Radiation Research. 2023
  • Narisa Dewi Maulany Darwis, Eisuke Horigome, Shan Li, Akiko Adachi, Takahiro Oike, Atsushi Shibata, Yuka Hirota, Tatsuya Ohno. Radiosensitization by the Selective Pan-FGFR Inhibitor LY2874455. Cells. 2022. 11. 11
  • Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Reika Kawabata-Iwakawa, Sayako Katada, Wenchao Gu, Sangeeta Kakoti, Motohiro Yamauchi, Reona Kato, Soehartati Gondhowiardjo, et al. DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production. Molecular cell. 2022. 82. 14. 2557-2570
  • Takaaki Yasuhara, Reona Kato, Motohiro Yamauchi, Yuki Uchihara, Lee Zou, Kiyoshi Miyagawa, Atsushi Shibata. RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair. Cell Reports. 2022. 38. 5. 110335-110335
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MISC (15)：
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Lectures and oral presentations  (60)：
  • RAP80 suppresses deleterious repair of double-strand break in transcribed genome
    (第10回 International Symposium on DNA Damage Response & Human Disease (isDDRHD) 2019)
  • DNA二本鎖切断修復経路の決定メカニズム
    (日本核酸医薬学会生物セッション第4回サテライトシンポジウム 2019)
  • Pursuing High-Quality Radiobiology & Radiation Oncology in Indonesia: from basics - clinics - publication
    (IROS Annual Scientific Meeting 2019)
  • Regulation of DSB repair pathway choice and its downstream signaling
    (第78回日本癌学会学術総会 シンポジウム「発がん微小環境におけるDNA修復欠損の役割」 2019)
  • Regulation of transcription-associated end-joining mediated by MRE11, BRCA1, Polθ and LIG1/3
    (16th International Congress of Radiation Research 2019 2019)
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Education (3)：
  • - 2006 Tokyo Medical and Dental University
  • - 2003 Kyoritsu College of Pharmacy Degree of Pharmaceutical Master
  • - 2001 Kyoritsu College of Pharmacy Faculty of medicine Department Bachelor of Pharmacy
Professional career (1)：
  • Medicine (Tokyo Medical and Dental University)
Work history (9)：
  • 2023/04 - 現在 Keio University Faculty of Pharmacy
  • 2019/04 - 2023/03 群馬大学
  • 2017/04 - 2019/03 Gunma University Education and Research Support Center (ERSC), Graduate School of Medicine
  • 2013 - 2017 Gunma University Advanced Scientific Research Leaders Development Unit
  • 2012 - 2013 University of Sussex JSPS postdoctoral fellowship for Research Abroad
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Awards (6)：
  • 2020/03 - 公益財団法人放射線影響協会 放射線影響研究 奨励賞
  • 2017 - 第24回 DNA複製・組換え・修復ワークショップ 若手発表賞
  • 2017 - 日本放射線影響学会第60回大会 優秀演題発表賞
  • 2017 - 放射線影響学会 奨励賞
  • 2012 - Joint British Association for Cancer Research-Gray Institute Poster prize
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Association Membership(s) (5)：
Frontiers in Aging (Editorial Board) ,  DNA Repair (Editorial Board) ,  日本生化学会 ,  日本抗加齢医学会 ,  日本薬学会
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