Rchr
J-GLOBAL ID：200901051376086650
Update date: Jan. 31, 2024
Saito Naoki
サイトウ ナオキ | Saito Naoki
Affiliation and department：
Job title：
Spacial Appointed Professor
Homepage URL (1)：
http://www.my-pharm.ac.jp/~pcns6mpu/wordpress/
Research field (2)：
Environmental and pharmaceutical development resources
, Pharmaceuticals - chemistry and drug development
Research keywords (5)：
Heterocycles
, Medicinal Chemistry
, Natural Products Chemistry
, Pharmceutical Chemistry
, Organic Chemistry
Research theme for competitive and other funds (16)：
- 2018 - 2021 新規光変換反応を基軸とする抗腫瘍活性海洋天然物の合成と創薬開発基盤の構築
- 2015 - 2018 Preparaion of Novel Anticancer Agents based on Isoquinoline Marine Natural Products
- 2011 - 2013 Development for medicinal chemistry on antitumor isoquinoline marine natural products as lead compound
- 2004 - 2005 Development of practical supply of isoquinoline marine natural products to designate the creation of the new anticancer agents
- 2002 - 2004 Medicinal chemistry on marine alkaloid as a seed of the development for a new anticancer drug in Malaya area
- 1998 - 2000 ピロロ〔2,3,4-kl]アクリジン骨格を有する生理活性天然物の合成
- 1998 - 1999 Synthetic Approach to the Total Synthesis of Natural Marine Isoquinoline Alkaloid
- 1999 - 新規抗腫瘍活性化合物の創製
- 1991 - 1992 Synthetic Studies on Biological Active Marine Natural Products Possessing Iminoquinolinequinone Structure
- 1988 - 1989 Syntheses of biological active natural products having highly alkylated piperazine ring
- マレー域薬用植物成分を先導化合物とする新規合成医薬品の開発研究
- リチウムパークロリドを用いる分子内Diels-Alder反応
- サフラマイシン系抗生物質の合成研究
- Medicinal Chemistry on Alkaloids from Plants in Malaya Area
- Intramolecular Diels-Alder Reaction using Lithium Perchlorade.
- Synthesis of saframycin antibiotics
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Papers (33)：
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Suwimon Sinsook, Koonchira Buaban, Iksen Iksen, Korrakod Petsri, Bhurichaya Innets, Chaisak Chansriniyom, Khanit Suwanborirux, Masashi Yokoya, Naoki Saito, Varisa Pongrakhananon, et al. Light-Mediated Transformation of Renieramycins and Semisynthesis of 4′-Pyridinecarbonyl-Substituted Renieramycin-Type Derivatives as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells. Marine Drugs. 2023. 21. 7. 400-400
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Masashi Yokoya, Ryo Fujimoto, Tomoki Kato, Taku Hashimoto, Shinya Kimura, Naoki Saito, Masamichi Yamanaka. Simple Strategy for Benzo[g]chromene Synthesis via a Photochemical Intramolecular Cyclization Reaction. The Journal of Organic Chemistry. 2023. 88. 13. 8714-8721
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Toshihiro Suzuki, Nachanun Sirimangkalakitti, Asami Baba, Ryoko Toyoshima-Nagasaki, Yuna Enomoto, Naoki Saito, Yuki Ogasawara. Characterization of the nucleotide excision repair pathway and evaluation of compounds for overcoming the cisplatin resistance of non-small cell lung cancer cell lines. Oncology Reports. 2022. 47. 4
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Masashi Yokoya, Ryo Sato, Naoki Saito. Lipase-Catalyzed Site-Selective Deacetylation of 2-Methoxy-3-methylnaphthalene-1,4-diol Diacetate for Construction of Characteristic Substituted 1,2,3,4-Tetrahydroisoquinoline Derivative of Novel Ecteinascidin Marine Natural Product. HETEROCYCLES. 2022. 105. 1. 511-511
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Yokoy M, Yamazaki-Nakai M, Nakai K, Sirimangkalakitti N, Chamni S, Suwanborirux K, Saito N. Transformation of Renieramycin M into Renieramycins T and S by Intramoecuar Photoredox Reaction of 7-Methoxy-6-methyl-1,2,3,4-tetrhydroisoquinine-5,8-dione Derivatives. J. Nat. Prod. 2022. 2022
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MISC (13)：
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N Saito, K Tashiro, Y Maru, K Yamaguchi, A Kubo. Synthetic approaches toward ecteinascidins .1. Preparation of an (E)-2-arylidene-3-benzyl-1,5-imino-3-benzazocin-4-one having a protected phenol in the E-ring. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1. 1997. 1. 53-69
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PA Grieco, MD Kaufman, JF Daeuble, N Saito. Carbocyclic ring construction via intramolecular ionic Diels-Alder reactions of in situ-generated, heteroatom-stabilized allyl cations in highly polar media. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1996. 118. 8. 2095-2096
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N SAITO, S HARADA, M YAMASHITA, T SAITO, K YAMAGUCHI, A KUBO. SYNTHESIS OF SAFRAMYCINS .11. SYNTHETIC STUDIES TOWARD A TOTAL SYNTHESIS OF SAFRACIN-A. TETRAHEDRON. 1995. 51. 30. 8213-8230
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N SAITO, S HARADA, INOUYE, I, K YAMAGUCHI, A KUBO. SYNTHESIS OF SAFRAMYCINS .12. TOTAL SYNTHESIS OF (-)-N-ACETYLSAFRAMYCIN-MX-2 AND ITS EPI-(+)-ENANTIOMER. TETRAHEDRON. 1995. 51. 30. 8231-8246
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N SAITO, S HARADA, M NISHIDA, INOUYE, I, A KUBO. SYNTHESIS OF SAFRAMYCINS .10. TRANSFORMATION OF (-)-SAFRAMYCIN-A TO (-)-SAFRAMYCIN-MX TYPE COMPOUND WITH THE STRUCTURE PROPOSED FOR SAFRAMYCIN-E. CHEMICAL & PHARMACEUTICAL BULLETIN. 1995. 43. 5. 777-782
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Books (2)：
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エクチナサイジン海洋天然物ー発見から新規抗がん剤の創製まで
2017
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Synthesis of Isoquinolinequinone Antibiotics(共著)
Studies on Natural Products Chemiwstry (Elsevier) 1992
Works (2)：
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Cationic Diels-Alder reaction using Lithium Perchlorate
1993 -
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Systhesis of Sframycins. IX. An Efficient Synthesis of the ABC Ring of Satracins.
1993 -
Education (3)：
- 1978 - 1988 Chiba University Graduate School, Division of Pharmaceutical Sciences
- - 1980 Chiba University
- 1974 - 1978 Chiba University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
Professional career (2)：
- Ph. D. (Chiba University)
- (BLANK)
Work history (7)：
- 2020/04 - 現在 Meiji Pharmaceutical University Faculty of Pharmaceutical Sciences Special Appointment Professor
- 2005/04 - 2020/03 Meiji Pharmaceutical University Faculty of Pharmaceutical Sciences Professor
- 2002 - 2005 Meiji Pharmaceutical University
- 1995 - 2002 Meiji Pharmaceutical University
- 1980 - 1995 Meiji Pharmaceutical University
- 1980 - 1995 Meiji Pharmaceutical University, Research
- 1992/04 - 1993/03 Indiana University Chemistry (Bloomington) Post Doctoral Fellow
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Committee career (9)：
- 2019/02 - 2020/01 社)日本薬学会関東支部 幹事(学術講演会担当委員長)
- 2016/07 - 2018/06 薬学奨励財団 選考委員会委員
- 2016/02 - 2017/01 社)日本薬学会 化学系薬学部会役員(副部会長)
- 2010/02 - 2014/01 日本薬学会 化学系薬学部会(会計担当)
- 2011/12 - 2013/11 独)日本学術振興会 科学研究費専門委員
- 2005/02 - 2008/01 Farumasia
- 2005/04 - 2006/03 日本薬学会 日本薬学会第128年会組織委員会
- 2002 - 2003 日本薬学会 日本薬学会関東支部企画委員会委員
- 1997 - 1998 有機合成化学協会 有機合成化学協会誌編集委員
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Awards (2)：
- 2019/03 - 日本薬学会 2019年度日本薬学会学術貢献賞(第1B部門) 抗腫瘍活性イソキノリンおよび関連化合物の化学的研究
- 2013/10 - JSPS 2013 JSPS Excellent Reviewer
Association Membership(s) (4)：
国際複素環化学協会
, アメリカ化学会
, 有機合成化学協会
, 日本薬学会
