Yamakuni Tohru

ヤマクニトオル | Yamakuni Tohru

Affiliation and department：
Homepage URL (1)： https://labo.yamakuni.me/

Research field (2)： Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (8)： CNS neurodegeneration , actin dynamics , F-actin capping protein , CAPZ , V-1 , 中枢神経系の遺伝子ネットワーク , 天然生理活性物質 , 神経機能再生

Research theme for competitive and other funds (9)：

2016 - 2019 Development of fundamental therapy for dopamine-related disorders targetting novel protein complex V-1/CP
2008 - 2010 Elucidation of novel molecular regulatory mechanisms underlying tyrosine hydroxylase functional expression and development of therapeutics for the CNS neurodegenerative disorders
2007 - 2008 Basic research for finding the mechanism of paradox appeared in Controlling asthma
2004 - 2005 Elucidation of physiological significance of a novel regulator of neuronal functions and its application to functional regeneration of brain
2004 - 2004 新しい医薬資源からの抗がん性物質の探索と分子標的の解明

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Papers (129)：

Junpei Kobayashi, Takafumi Hasegawa, Naoto Sugeno, Shun Yoshida, Tetsuya Akiyama, Koki Fujimori, Hiroyasu Hatakeyama, Yasuo Miki, Arata Tomiyama, Yasushi Kawata, et al. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019. 33. 9. 10240-10256
山國徹, 川畑伊知郎. イミダクロプリドは低濃度で中脳ドパミン神経のニコチン受容体分子の細胞膜集積を促し、THの転写を増強する. 日本臨床環境医学会総会プログラム・抄録集. 2019. 28回. 62-62
Ichiro Kawahata, Huinan Xu, Michiyo Takahashi, Kiyoshi Murata, Wanying Han, Yoshihisa Yamaguchi, Akira Fujii, Kikuji Yamaguchi, Tohru Yamakuni. Royal jelly coordinately enhances hippocampal neuronal expression of somatostatin and neprilysin genes conferring neuronal protection against toxic soluble amyloid-β oligomers implicated in Alzheimer’s disease pathogenesis. Journal of Functional Foods. 2018. 51. 28-38
Cong-Yuan Xia, Zhen-Zhen Wang, Tohru Yamakuni, Nai-Hong Chen. A novel mechanism of depression: role for connexins. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2018. 28. 4. 483-498
Ichiro Kawahata, Tohru Yamakuni. Imidacloprid, a neonicotinoid insecticide, facilitates tyrosine hydroxylase transcription and phenylethanolamine N-methyltransferase mRNA expression to enhance catecholamine synthesis and its nicotine-evoked elevation in PC12D cells. Toxicology. 2018. 394. 84-92

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MISC (142)：

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Books (1)：

新規神経機能制御因子の生理学的機能の解明と脳機能再生への応用
[山國徹] 2006

Lectures and oral presentations (15)：

低分子性の神経成長因子様分化誘導物質の探索および作用機構の解明
(第54回日本薬理学会北部会 2003)
金糸梅カルスにおけるNF-B依存的な転写促進を抑制する天然生理活性物質の探索
(第54回日本薬理学会北部会 2003)
マンゴスチン果皮抽出物の機能性食品への応用(第1報)抗酸化作用の検討
(日本生薬学会第50回年会 2003)
アポトーシス誘導物質IC101によるHSP90阻害作用の検討
(第7回がん分子標的治療研究会総会 2003)
C6ラットグリオーマ細胞におけるPGE2合成・遊離に対する-mangostin類縁体の作用
(日本薬学会第123回年会 2003)

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Education (1)：

- 1985 Niigata University

Work history (4)：

2020/04 - Tohoku University New Industry Creation Hatchery Center
2020/04 - Tohoku University Graduate School of Engineering Research Center of Supercritical Fluid Technology
2001/07 - 2020/03 Tohoku University Graduate School of Pharmaceutical Sciences
1986/05 - 2001/06 三菱化成(現三菱化学)生命科学研究所

Committee career (1)：

一般社団法人日本私立薬科大学協会薬剤師国家試験問題検討委員会病態・薬物治療部会委員

Awards (1)：

2005/12 - 財団法人武田科学振興財団 2005年度「シンポジウム研究奨励」賞

Association Membership(s) (1)：

日本薬理学会

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