Funamoto Satoru

フナモトサトル | Funamoto Satoru

Affiliation and department：

Research field (1)： Neuroanatomy and physiology

Research keywords (8)：ホスフォイノシチド , ガンマセクレターゼ , アルツハイマー病 , アミロイドβ , phosphoinositides , gamma-secretase , Alzheimer Disease , Amyloid beta protein

Research theme for competitive and other funds (12)：

2022 - 2025 Understanding of A potential defense mechanism against amyloid deposition in cerebellum
2016 - 2019 Identification of glycosylation site involving into substrate preference of gamma-secretase
2005 - 2009 Characterization of the enzymatic properties of γ-secretase
2005 - 2006 アミロイド前駆体タンパク質のガンマ切断部位を制御する因子の探索
2003 - 2004 ガンマセクレターゼの同定とアミロイドベータタンパク質Aβ42の産生機序

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Papers (37)：

Sato W, Watanabe-Takahashi M, Murata T, Utsunomiya-Tate N, Motoyama J, Anzai M, Ishihara S, Nishioka N, Uchiyama H, Togashi J, et al. A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation. Commun. Biol. 2023. 6(1)383. 1. 383-383
Rikuya Yoshimura, Tomohiro Miyasaka, Satoru Funamoto, Takashi Saito, Takaomi C Saido, Masaya Ikegawa, Nobuto Kakuda. The senile plaque: Morphological differences in APP knock-in mice brains by fixatives. Brain and behavior. 2023. e2953
Waka Sato, Miho Watanabe-Takahashi, Takashi Hamabata, Koichi Furukawa, Satoru Funamoto, Kiyotaka Nishikawa. A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid β by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit. Biochemical and Biophysical Research Communications. 2021. 557. 247-253
Shahnur Alam, Masaki Nakano, Seiko Ishihara, Nobuto Kakuda, Tomohiro Miyasaka, Hina Uchiyama, Yuuna Shirai, Mohammad Moniruzzaman, Takashi Saito, Takaomi C. Saido, et al. A potential defense mechanism against amyloid deposition in cerebellum. Biochemical and Biophysical Research Communications. 2021. 535. 25-32
Satoru Funamoto, Shinji Tagami, Masayasu Okochi, Maho Morishima-Kawashima. Successive cleavage of β-amyloid precursor protein by γ-secretase. Seminars in Cell & Developmental Biology. 2020. 105. 64-74

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MISC (37)：

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Patents (5)：

Books (8)：

デブリン生化学
丸善出版 2013
Equimolar production of Aβ and AICD from C99 by γ-secretase
2006
Equimolar production of Aβ and AICD from C99 by γ-secretase
10th International Conference on Alzheimer's Disease and Related Disorders Alzheimer's Disease : New Advances 2006
Directional sensing : Subcellular targeting of GPCR downstream effectors during chemotaxis In : Cell Motility : From Molecules to Organisms
2004
Directional sensing : Subcellular targeting of GPCR downstream effectors during chemotaxis In : Cell Motility : From Molecules to Organisms
John Wiley & Sons, Ltd 2004

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Lectures and oral presentations (25)：

抗アミロイド療法としてのAPP特異的切断抑制
(第42回日本認知症学会学術集会 2023)
副作用のない抗アミロイド療法の開発
(第96回日本生化学会大会シンポジウム 2S03e 2023)
Potential determination mechanism of epsilon-cleavage sites: Implication for determinants of Abeta40 and Abeta42 product lines
(ADPD2017 2017)
APP A673T mutation reduces not only b-cleavage but also g-cleavage of APP in cells
(ADPD2015 2015)
アミロイドβの産生機序と産生抑制
(認知症の最新発症メカニズムと治療薬開発 2015)

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Professional career (2)：

Work history (4)：

Committee career (1)：

Awards (2)：

Association Membership(s) (4)：

米国神経科学会 , 日本分子生物学会 , SFN , Molecular Biology Society of Japan

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